L773:1557 1882
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- Nordin, ConnyÖstergötlands Läns Landsting,Linköpings universitet,Psykiatri,Hälsouniversitetet,Psykiatriska kliniken (author)
Increased CSF homocysteine in pathological gamblers compared with healthy controls
- Article/chapterEnglish2009
Publisher, publication year, extent ...
- 2008-12-16
- Springer,2009
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:liu-18856
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-18856URI
- https://doi.org/10.1007/s11469-008-9172-2DOI
Supplementary language notes
- Language:English
- Summary in:English
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- SwePubSwePub
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Notes
- Neurocognitive disturbances suggesting a frontal lobe dysfunction have been observed in pathological gamblers and alcohol dependents. Given that a high homocysteine level has been suggested to be a mediating factor in alcohol-related cognitive decline, we have determined homocysteine and cobalamine in cerebrospinal fluid (CSF) obtained from 11 pathological male gamblers and 11 healthy male controls. Compared with healthy controls, pathological gamblers displayed higher CSF levels of homocysteine while the opposite was the case with CSF cobalamine. Smoking decreased the levels of homocysteine while the concentrations of cobalamine were increased. Homocysteine is a sulphur-containing amino acid exerting cytotoxic effects in living cells. The metabolism of homocysteine to methionine is mediated by cobalamine and folate. Human studies suggest that homocysteine plays a role in brain damage and cognitive and memory decline. The relationship between pathological gambling, homocysteine, cobalamine, folate (not determined in the study) and cognitive processing warrants further investigation.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Beroendelära hsv//swe
- MEDICAL AND HEALTH SCIENCES Health Sciences Substance Abuse hsv//eng
- Cobalamine; CSF; Homocysteine; Pathological gambling
- MEDICINE
- MEDICIN
Added entries (persons, corporate bodies, meetings, titles ...)
- Sjödin, IngemarÖstergötlands Läns Landsting,Linköpings universitet,Psykiatri,Hälsouniversitetet,Psykiatriska kliniken(Swepub:liu)ingsj97 (author)
- Linköpings universitetPsykiatri (creator_code:org_t)
Related titles
- In:International Journal of Mental Health and Addiction: Springer7:1, s. 168-1761557-18741557-1882
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