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  • Ammirati, EnricoOsped Niguarda Ca Granda, Italy; Osped Niguarda Ca Granda, Italy (author)

Acute Myocarditis Associated With Desmosomal Gene Variants

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • ELSEVIER SCI LTD,2022
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-190234
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-190234URI
  • https://doi.org/10.1016/j.jchf.2022.06.013DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies|Italian Ministry of Health [GR-2019-12368506]
  • BACKGROUND The risk of adverse cardiovascular events in patients with acute myocarditis (AM) and desmosomal gene variants (DGV) remains unknown.OBJECTIVES The purpose of this study was to ascertain the risk of death, ventricular arrhythmias, recurrent myocarditis, and heart failure (main endpoint) in patients with AM and pathogenic or likely pathogenetic DGV.METHODS In a retrospective international study from 23 hospitals, 97 patients were included: 36 with AM and DGV (DGV[+]), 25 with AM and negative gene testing (DGV[-]), and 36 with AM without genetics testing. All patients had troponin elevation plus findings consistent with AM on histology or at cardiac magnetic resonance (CMR). In 86 patients, CMR changes in function and structure were re-assessed at follow-up.RESULTS In the DGV(+) AM group (88.9% DSP variants), median age was 24 years, 91.7% presented with chest pain, and median left ventricular ejection fraction (LVEF) was 56% on CMR (P = NS vs the other 2 groups). Kaplan-Meier curves demonstrated a higher risk of the main endpoint in DGV(+) AM compared with DGV(-) and without genetics testing patients (62.3% vs 17.5% vs 5.3% at 5 years, respectively; P < 0.0001), driven by myocarditis recurrence and ventricular arrhythmias. At follow-up CMR, a higher number of late gadolinium enhanced segments was found in DGV(+) AM. CONCLUSIONS Patients with AM and evidence of DGV have a higher incidence of adverse cardiovascular events compared with patients with AM without DGV. Further prospective studies are needed to ascertain if genetic testing might improve risk stratification of patients with AM who are considered at low risk. (J Am Coll Cardiol HF 2022;10:714-727) (c) 2022 by the American College of Cardiology Foundation.

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  • Raimondi, FrancescaM3C Hop Necker Enfants Malad, France (author)
  • Piriou, NicolasUniv Nantes, France (author)
  • Infirri, Loren SardoOsped Circolo Varese, Italy (author)
  • Mohiddin, Saidi A.St Bartholomews Hosp, England (author)
  • Mazzanti, AndreaIRCCS, Italy; Univ Pavia, Italy (author)
  • Shenoy, ChetanUniv Minnesota, MN USA (author)
  • Cavallari, Ugo A.Osped Niguarda Ca Granda, Italy (author)
  • Imazio, MassimoCardiothorac Dept, Italy (author)
  • Aquaro, Giovanni DonatoGabriele Monasterio Fdn, Italy (author)
  • Olivotto, IacopoCareggi Univ Hosp, Italy (author)
  • Pedrotti, PatriziaOsped Niguarda Ca Granda, Italy (author)
  • Sekhri, NehaSt Bartholomews Hosp, England (author)
  • Heyning, Caroline M. Van deAntwerp Univ Hosp, Belgium (author)
  • Broeckx, GlennAntwerp Univ Hosp, Belgium (author)
  • Peretto, GiovanniUniv Vita Salute San Raffaele, Italy (author)
  • Guttmann, OliverSt Bartholomews Hosp, England (author)
  • Dellegrottaglie, SantoClin Villa Fiori, Italy (author)
  • Scatteia, AlessandraClin Villa Fiori, Italy (author)
  • Gentile, PieroOsped Niguarda Ca Granda, Italy (author)
  • Merlo, MarcoUniv Trieste, Italy (author)
  • Goldberg, Randal I.NYU Langone Hlth, NY USA (author)
  • Reyentovich, AlexNYU Langone Hlth, NY USA (author)
  • Sciamanna, ChristopherUniv Illinois, IL USA (author)
  • Klaassen, SabineCorp Member Freie Universitdt Berlin & Humboldt Un, Germany; Expt & Clin Res Ctr, Germany (author)
  • Poller, WolfgangCorp Member Freie Universitdt Berlin & Humboldt Un, Germany; German Ctr Cardiovasc Res, Germany; Dept Cardiol, Germany (author)
  • Trankle, Cory R.Virginia Commonwealth Univ, VA USA (author)
  • Abbate, AntonioVirginia Commonwealth Univ, VA USA (author)
  • Keren, AndreHadassah Hebrew Univ Med Ctr, Israel (author)
  • Horowitz-Cederboim, SmadarHadassah Ctr Cardiogenet, Israel (author)
  • Cadrin-Tourigny, JuliaUniv Montreal, Canada (author)
  • Tadros, RafikUniv Montreal, Canada (author)
  • Annoni, Giuseppe A.Osped Niguarda Ca Granda, Italy (author)
  • Bonoldi, EmanuelaOsped Niguarda Ca Granda, Italy (author)
  • Toquet, ClaireUniv Nantes, France; Nantes Univ, France (author)
  • Marteau, LaraUniv Nantes, France (author)
  • Probst, VincentUniv Nantes, France (author)
  • Trochu, Jean NoelUniv Nantes, France (author)
  • Kissopoulou, AntheiaLinköpings universitet,Institutionen för hälsa, medicin och vård,Medicinska fakulteten(Swepub:liu)n/a (author)
  • Grosu, AureliaCardiovasc Dept, Italy (author)
  • Kukavica, DeniIRCCS, Italy; Univ Pavia, Italy (author)
  • Trancuccio, AlessandroIRCCS, Italy; Univ Pavia, Italy (author)
  • Gil, CristinaUniv Hosp Virgen Arrixaca, Spain; Univ Genoa, Italy (author)
  • Pedrazzini, MatteoIRCCS Ist Auxol Italiano, Italy (author)
  • Torchio, MargheritaIRCCS Ist Auxol Italiano, Italy (author)
  • Sinagra, GianfrancoUniv Trieste, Italy (author)
  • Gimeno, Juan RamonUniv Hosp Virgen Arrixaca, Spain (author)
  • Bernasconi, DavideUniv Milano Bicocca, Italy (author)
  • Valsecchi, Maria GraziaUniv Milano Bicocca, Italy (author)
  • Klingel, KarinUniv Hosp Tubingen, Germany (author)
  • Adler, Eric D.Univ Calif San Diego, CA USA (author)
  • Camici, Paolo G.Univ Vita Salute San Raffaele, Italy (author)
  • Cooper, Leslie T.Mayo Clin, FL USA; Mayo Clin Florida, FL 32224 USA (author)
  • Osped Niguarda Ca Granda, Italy; Osped Niguarda Ca Granda, ItalyM3C Hop Necker Enfants Malad, France (creator_code:org_t)

Related titles

  • In:JACC. Heart failure: ELSEVIER SCI LTD10:10, s. 714-7272213-17792213-1787

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