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  • Byrne, JulianneBoyne Research Institute,Boyne Res Inst, Drogheda, Ireland. (author)

Impact of era of diagnosis on cause-specific late mortality among 77 423 five-year European survivors of childhood and adolescent cancer : The PanCareSurFup consortium

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • 2021-10-21
  • Wiley,2022

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:d9170eae-50a6-4a33-a13e-9b83f5d34d98
  • https://lup.lub.lu.se/record/d9170eae-50a6-4a33-a13e-9b83f5d34d98URI
  • https://doi.org/10.1002/ijc.33817DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-470105URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Late mortality of European 5-year survivors of childhood or adolescent cancer has dropped over the last 60 years, but excess mortality persists. There is little information concerning secular trends in cause-specific mortality among older European survivors. PanCareSurFup pooled data from 12 cancer registries and clinics in 11 European countries from 77 423 five-year survivors of cancer diagnosed before age 21 between 1940 and 2008 followed for an average age of 21 years and a total of 1.27 million person-years to determine their risk of death using cumulative mortality, standardized mortality ratios (SMR), absolute excess risks (AER), and multivariable proportional hazards regression analyses. At the end of follow-up 9166 survivors (11.8%) had died compared to 927 expected (SMR 9.89, 95% confidence interval [95% CI] 9.69-10.09), AER 6.47 per 1000 person-years, (95% CI 6.32-6.62). At 60 to 68 years of attained age all-cause mortality was still higher than expected (SMR = 2.41, 95% CI 1.90-3.02). Overall cumulative mortality at 25 years from diagnosis dropped from 18.4% (95% CI 16.5-20.4) to 7.3% (95% CI 6.7-8.0) over the observation period. Compared to the diagnosis period 1960 to 1969, the mortality hazard ratio declined for first neoplasms (P for trend <.0001) and for infections (P <.0001); declines in relative mortality from second neoplasms and cardiovascular causes were less pronounced (P =.1105 and P =.0829, respectively). PanCareSurFup is the largest study with the longest follow-up of late mortality among European childhood and adolescent cancer 5-year survivors, and documents significant mortality declines among European survivors into modern eras. However, continuing excess mortality highlights survivors' long-term care needs.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Schmidtmann, IreneUniversitätsmedizin Mainz,Johannes Gutenberg Univ Mainz, Univ Med Ctr, Inst Med Biostat Epidemiol & Informat, Mainz, Germany. (author)
  • Rashid, HumayraUniversitätsmedizin Mainz,Johannes Gutenberg Univ Mainz, Univ Med Ctr, Inst Med Biostat Epidemiol & Informat, Mainz, Germany. (author)
  • Hagberg, OskarRegional Cancer Centre South,Reg Canc Ctr South, Lund, Sweden.(Swepub:lu)mats-oha (author)
  • Bagnasco, FrancescaGaslini Children's Hospital,IRCCS Ist Giannina Gaslini, Epidemiol & Biostat Unit, Genoa, Italy.;IRCCS Ist Giannina Gaslini, DOPO Clin, Genoa, Italy. (author)
  • Bardi, EditKepler University Hospital Linz,St. Anna Children's Hospital,St Anna Childrens Hosp, Vienna, Austria.;Johannes Kepler Univ Linz, Kepler Univ Hosp GmbH, Dept Pediat & Adolescent Med, Linz, Austria. (author)
  • De Vathaire, FlorentCentre for Research in Epidemiology and Population Health (CESP),Institut Gustave Roussy,University of Paris-Saclay,Ctr Res Epidemiol & Populat Hlth CESP, INSERM, Villejuif, France.;Univ Paris Sud Orsay, Villejuif, France.;Gustave Roussy, Dept Res, Villejuif, France. (author)
  • Essiaf, SamiraSIOPE, Clos Chapelle Aux Champs 30, Brussels, Belgium. (author)
  • Winther, Jeanette FalckAarhus University Hospital,Danish Cancer Society,Danish Canc Soc Res Ctr, Copenhagen, Denmark.;Aarhus Univ, Fac Hlth, Dept Clin Med, Aarhus, Denmark. (author)
  • Frey, EvaSt. Anna Children's Hospital (author)
  • Gudmundsdottir, ThorgerdurNational University Hospital of Iceland,Danish Cancer Society,Danish Canc Soc Res Ctr, Copenhagen, Denmark.;Landspitali Univ Hosp, Childrens Hosp, Reykjavik, Iceland. (author)
  • Haupt, RiccardoGaslini Children's Hospital,IRCCS Ist Giannina Gaslini, Epidemiol & Biostat Unit, Genoa, Italy.;IRCCS Ist Giannina Gaslini, DOPO Clin, Genoa, Italy. (author)
  • Hawkins, Michael M.University of Birmingham,Univ Birmingham, Inst Appl Hlth Res, Ctr Childhood Canc Survivor Studies, Birmingham, W Midlands, England.,Univ Turin, Dept Med Sci, Childhood Canc Registry Piedmont, Turin, Italy.;Ctr Canc Prevent CPO Piemonte, Turin, Italy. (author)
  • Jakab, ZsuzsannaSemmelweis University,Semmelweis Univ, Dept Pediat 2, Hungarian Childhood Canc Registry, Budapest, Hungary. (author)
  • Jankovic, MomciloUniversity of Milano-Bicocca,Univ Milano Bicocca, Fdn MBBM, Pediat Clin, Milan, Italy.;Italian Off Therapy Register OTR, Monza, Italy. (author)
  • Kaatsch, PeterJohannes-Gutenberg University Mainz,Johannes Gutenberg Univ Mainz, Inst Med Biostat Epidemiol & Informat IMBEI, Div Childhood Canc Epidemiol, German Childhood Canc Registry GCCR, Mainz, Germany. (author)
  • Kremer, Leontien C.M.Academic Medical Center of University of Amsterdam (AMC),Emma Childrens Hosp, Amsterdam UMC, Dept Pediat Oncol, Amsterdam, Netherlands. (author)
  • Kuehni, Claudia E.University Children's Hospital Bern,Univ Bern, Inst Social & Prevent Med, Swiss Childhood Canc Registry, Bern, Switzerland.;Univ Bern, Univ Childrens Hosp Bern, Dept Paediat, Paediat Oncol, Bern, Switzerland. (author)
  • Harila-Saari, Arja H.Uppsala universitet,Uppsala University,Barnonkologisk och neurologisk forskning(Swepub:uu)arjha456 (author)
  • Levitt, GillGreat Ormond Street Hospital,Great Ormond St Hosp Children NHS Fdn Trust, Great Ormond St, London, England. (author)
  • Reulen, RaoulUniversity of Birmingham,Univ Birmingham, Inst Appl Hlth Res, Ctr Childhood Canc Survivor Studies, Birmingham, W Midlands, England. (author)
  • Ronckers, Cécile M.Princess Maxima Center for Pediatric Oncology/Hematology,Princess Maxima Ctr Paediat Oncol, Utrecht, Netherlands.;Inst Biostat & Registry Res, Brandenburg Med Sch, Neuruppin, Germany. (author)
  • Maule, MilenaUniversity of Turin (author)
  • Skinner, RoderickRoyal Victoria Infirmary,University of Newcastle upon Tyne,Newcastle Univ, Ctr Canc, Translat & Clin Res Inst, Newcastle Upon Tyne, Tyne & Wear, England.;Great North Childrens Hosp, Royal Victoria Infirm, Dept Paediat & Adolescent Haematol & Oncol, Newcastle Upon Tyne, Tyne & Wear, England. (author)
  • Steliarova-Foucher, EvaInternational Agency for Research on Cancer, World Health Organization,Int Agcy Res Canc, Sect Canc Surveillance, Lyon, France. (author)
  • Terenziani, MonicaIstituto Nazionale dei Tumori,Fdn IRCCS Ist Nazl Tumori, Pediat Oncol Unit, Milan, Italy. (author)
  • Zaletel, Lorna ZadravecInstitute of Oncology, Ljubljana,Inst Oncol, Div Radiotherapy, Ljubljana, Slovenia. (author)
  • Hjorth, LarsLund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Sena effekter efter barncancerbehandling,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Late effects after childhood cancer treatment,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital,Lund Univ, Skane Univ Hosp, Dept Clin Sci Lund, Lund, Sweden.(Swepub:lu)pedi-lhj (author)
  • Garwicz, StanislawLund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Sena effekter efter barncancerbehandling,Forskargrupper vid Lunds universitet,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Late effects after childhood cancer treatment,Lund University Research Groups,Skåne University Hospital,Lund Univ, Skane Univ Hosp, Dept Clin Sci Lund, Lund, Sweden.(Swepub:lu)st6750ga (author)
  • Grabow, DesireeJohannes-Gutenberg University Mainz (author)
  • Boyne Research InstituteBoyne Res Inst, Drogheda, Ireland. (creator_code:org_t)

Related titles

  • In:International Journal of Cancer: Wiley150:3, s. 406-4190020-71361097-0215

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