Association of time-to-intravenous furosemide with mortality in acute heart failure: data from REPORT-HF

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MARC

Ouwerkerk, WouterNatl Heart Ctr Singapore, Singapore; Univ Amsterdam, Netherlands (author)

Association of time-to-intravenous furosemide with mortality in acute heart failure : data from REPORT-HF

Article/chapterEnglish2023

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2022-11-23
Wiley,2023
electronicrdacarrier

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LIBRIS-ID:oai:DiVA.org:liu-190633
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-190633URI
https://doi.org/10.1002/ejhf.2708DOI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype

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Funding Agencies|National University of Singapore; Singapore Ministry of Education; CS-IRG New Investigator Grant from the National Medical Research; Novartis
AimAcute heart failure can be a life-threatening medical condition. Delaying administration of intravenous furosemide (time-to-diuretics) has been postulated to increase mortality, but prior reports have been inconclusive. We aimed to evaluate the association between time-to-diuretics and mortality in the international REPORT-HF registry.Methods and resultsWe assessed the association of time-to-diuretics within the first 24 h with in-hospital and 30-day post-discharge mortality in 15 078 patients from seven world regions in the REPORT-HF registry. We further tested for effect modification by baseline mortality risk (ADHERE risk score), left ventricular ejection fraction (LVEF) and region. The median time-to-diuretics was 67 (25th-75th percentiles 17-190) min. Women, patients with more signs and symptoms of heart failure, and patients from Eastern Europe or Southeast Asia had shorter time-to-diuretics. There was no significant association between time-to-diuretics and in-hospital mortality (p > 0.1). The 30-day mortality risk increased linearly with longer time-to-diuretics (administered between hospital arrival and 8 h post-hospital arrival) (p = 0.016). This increase was more significant in patients with a higher ADHERE risk score (p(interaction) = 0.008), and not modified by LVEF or geographic region (p(interaction) > 0.1 for both).ConclusionIn REPORT-HF, longer time-to-diuretics was not associated with higher in-hospital mortality. However, we did found an association with increased 30-day mortality, particularly in high-risk patients, and irrespective of LVEF or geographic region.Clinical Trial Registration: ClinicalTrials.gov Identifier NCT02595814.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
Heart failure; Diuretics

Added entries (persons, corporate bodies, meetings, titles ...)

Tromp, JasperDuke Natl Univ Singapore, Singapore; Natl Univ Singapore, Singapore; Natl Univ Hlth Syst, Singapore (author)
Cleland, John G. F.Univ Glasgow, Scotland; Imperial Coll, England (author)
Angermann, Christiane E.Univ Wurzburg, Germany; Univ Hosp Wurzburg, Germany (author)
Dahlström, UlfLinköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US(Swepub:liu)ulfda85 (author)
Ertl, GeorgUniv Wurzburg, Germany; Univ Hosp Wurzburg, Germany (author)
Hassanein, MahmoudAlexandria Univ, Egypt (author)
Perrone, Sergio VEl Cruce Hosp Florencio Varela, Argentina (author)
Ghadanfar, MathieuM Ghadanfar Consulting Life Sci, Switzerland (author)
Schweizer, AnjaNovartis Pharma AG, Switzerland (author)
Obergfell, AchimNovartis Pharma AG, Switzerland (author)
Dickstein, KennethUniv Bergen, Norway (author)
Filippatos, GerasimosNatl & Kapodistrian Univ Athens, Greece (author)
Collins, Sean P.Vanderbilt Univ, TN USA (author)
Lam, Carolyn S. P.Natl Heart Ctr Singapore, Singapore; Duke Natl Univ Singapore, Singapore (author)
Natl Heart Ctr Singapore, Singapore; Univ Amsterdam, NetherlandsDuke Natl Univ Singapore, Singapore; Natl Univ Singapore, Singapore; Natl Univ Hlth Syst, Singapore (creator_code:org_t)

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In:European Journal of Heart Failure: Wiley25:1, s. 43-511388-98421879-0844

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By the author/editor: Ouwerkerk, Woute ...; Tromp, Jasper; Cleland, John G. ...; Angermann, Chris ...; Dahlström, Ulf; Ertl, Georg; show more...; Hassanein, Mahmo ...; Perrone, Sergio ...; Ghadanfar, Mathi ...; Schweizer, Anja; Obergfell, Achim; Dickstein, Kenne ...; Filippatos, Gera ...; Collins, Sean P.; Lam, Carolyn S. ...; show less...

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