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Association of time...
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Ouwerkerk, WouterNatl Heart Ctr Singapore, Singapore; Univ Amsterdam, Netherlands
(author)
Association of time-to-intravenous furosemide with mortality in acute heart failure : data from REPORT-HF
- Article/chapterEnglish2023
Publisher, publication year, extent ...
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2022-11-23
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Wiley,2023
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:liu-190633
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-190633URI
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https://doi.org/10.1002/ejhf.2708DOI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Funding Agencies|National University of Singapore; Singapore Ministry of Education; CS-IRG New Investigator Grant from the National Medical Research; Novartis
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AimAcute heart failure can be a life-threatening medical condition. Delaying administration of intravenous furosemide (time-to-diuretics) has been postulated to increase mortality, but prior reports have been inconclusive. We aimed to evaluate the association between time-to-diuretics and mortality in the international REPORT-HF registry.Methods and resultsWe assessed the association of time-to-diuretics within the first 24 h with in-hospital and 30-day post-discharge mortality in 15 078 patients from seven world regions in the REPORT-HF registry. We further tested for effect modification by baseline mortality risk (ADHERE risk score), left ventricular ejection fraction (LVEF) and region. The median time-to-diuretics was 67 (25th-75th percentiles 17-190) min. Women, patients with more signs and symptoms of heart failure, and patients from Eastern Europe or Southeast Asia had shorter time-to-diuretics. There was no significant association between time-to-diuretics and in-hospital mortality (p > 0.1). The 30-day mortality risk increased linearly with longer time-to-diuretics (administered between hospital arrival and 8 h post-hospital arrival) (p = 0.016). This increase was more significant in patients with a higher ADHERE risk score (p(interaction) = 0.008), and not modified by LVEF or geographic region (p(interaction) > 0.1 for both).ConclusionIn REPORT-HF, longer time-to-diuretics was not associated with higher in-hospital mortality. However, we did found an association with increased 30-day mortality, particularly in high-risk patients, and irrespective of LVEF or geographic region.Clinical Trial Registration: ClinicalTrials.gov Identifier NCT02595814.
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Tromp, JasperDuke Natl Univ Singapore, Singapore; Natl Univ Singapore, Singapore; Natl Univ Hlth Syst, Singapore
(author)
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Cleland, John G. F.Univ Glasgow, Scotland; Imperial Coll, England
(author)
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Angermann, Christiane E.Univ Wurzburg, Germany; Univ Hosp Wurzburg, Germany
(author)
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Dahlström, UlfLinköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US(Swepub:liu)ulfda85
(author)
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Ertl, GeorgUniv Wurzburg, Germany; Univ Hosp Wurzburg, Germany
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Hassanein, MahmoudAlexandria Univ, Egypt
(author)
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Perrone, Sergio VEl Cruce Hosp Florencio Varela, Argentina
(author)
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Ghadanfar, MathieuM Ghadanfar Consulting Life Sci, Switzerland
(author)
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Schweizer, AnjaNovartis Pharma AG, Switzerland
(author)
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Obergfell, AchimNovartis Pharma AG, Switzerland
(author)
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Dickstein, KennethUniv Bergen, Norway
(author)
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Filippatos, GerasimosNatl & Kapodistrian Univ Athens, Greece
(author)
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Collins, Sean P.Vanderbilt Univ, TN USA
(author)
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Lam, Carolyn S. P.Natl Heart Ctr Singapore, Singapore; Duke Natl Univ Singapore, Singapore
(author)
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Natl Heart Ctr Singapore, Singapore; Univ Amsterdam, NetherlandsDuke Natl Univ Singapore, Singapore; Natl Univ Singapore, Singapore; Natl Univ Hlth Syst, Singapore
(creator_code:org_t)
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In:European Journal of Heart Failure: Wiley25:1, s. 43-511388-98421879-0844
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Ouwerkerk, Woute ...
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Tromp, Jasper
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Hassanein, Mahmo ...
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