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Association of time...
Association of time-to-intravenous furosemide with mortality in acute heart failure : data from REPORT-HF
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- Ouwerkerk, Wouter (author)
- Natl Heart Ctr Singapore, Singapore; Univ Amsterdam, Netherlands
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- Tromp, Jasper (author)
- Duke Natl Univ Singapore, Singapore; Natl Univ Singapore, Singapore; Natl Univ Hlth Syst, Singapore
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- Cleland, John G. F. (author)
- Univ Glasgow, Scotland; Imperial Coll, England
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- Angermann, Christiane E. (author)
- Univ Wurzburg, Germany; Univ Hosp Wurzburg, Germany
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- Dahlström, Ulf (author)
- Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US
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- Ertl, Georg (author)
- Univ Wurzburg, Germany; Univ Hosp Wurzburg, Germany
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- Hassanein, Mahmoud (author)
- Alexandria Univ, Egypt
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- Perrone, Sergio V (author)
- El Cruce Hosp Florencio Varela, Argentina
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- Ghadanfar, Mathieu (author)
- M Ghadanfar Consulting Life Sci, Switzerland
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- Schweizer, Anja (author)
- Novartis Pharma AG, Switzerland
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- Obergfell, Achim (author)
- Novartis Pharma AG, Switzerland
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- Dickstein, Kenneth (author)
- Univ Bergen, Norway
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- Filippatos, Gerasimos (author)
- Natl & Kapodistrian Univ Athens, Greece
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- Collins, Sean P. (author)
- Vanderbilt Univ, TN USA
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- Lam, Carolyn S. P. (author)
- Natl Heart Ctr Singapore, Singapore; Duke Natl Univ Singapore, Singapore
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(creator_code:org_t)
- 2022-11-23
- 2023
- English.
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In: European Journal of Heart Failure. - : Wiley. - 1388-9842 .- 1879-0844. ; 25:1, s. 43-51
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- AimAcute heart failure can be a life-threatening medical condition. Delaying administration of intravenous furosemide (time-to-diuretics) has been postulated to increase mortality, but prior reports have been inconclusive. We aimed to evaluate the association between time-to-diuretics and mortality in the international REPORT-HF registry.Methods and resultsWe assessed the association of time-to-diuretics within the first 24 h with in-hospital and 30-day post-discharge mortality in 15 078 patients from seven world regions in the REPORT-HF registry. We further tested for effect modification by baseline mortality risk (ADHERE risk score), left ventricular ejection fraction (LVEF) and region. The median time-to-diuretics was 67 (25th-75th percentiles 17-190) min. Women, patients with more signs and symptoms of heart failure, and patients from Eastern Europe or Southeast Asia had shorter time-to-diuretics. There was no significant association between time-to-diuretics and in-hospital mortality (p > 0.1). The 30-day mortality risk increased linearly with longer time-to-diuretics (administered between hospital arrival and 8 h post-hospital arrival) (p = 0.016). This increase was more significant in patients with a higher ADHERE risk score (p(interaction) = 0.008), and not modified by LVEF or geographic region (p(interaction) > 0.1 for both).ConclusionIn REPORT-HF, longer time-to-diuretics was not associated with higher in-hospital mortality. However, we did found an association with increased 30-day mortality, particularly in high-risk patients, and irrespective of LVEF or geographic region.Clinical Trial Registration: ClinicalTrials.gov Identifier NCT02595814.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Heart failure; Diuretics
Publication and Content Type
- ref (subject category)
- art (subject category)
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Ouwerkerk, Woute ...
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Tromp, Jasper
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Cleland, John G. ...
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Angermann, Chris ...
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Dahlström, Ulf
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Ertl, Georg
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Hassanein, Mahmo ...
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Perrone, Sergio ...
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Ghadanfar, Mathi ...
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Schweizer, Anja
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Obergfell, Achim
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Dickstein, Kenne ...
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Filippatos, Gera ...
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Collins, Sean P.
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Lam, Carolyn S. ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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European Journal ...
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Linköping University