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  • Herrmann, Job J.Radboud Univ Nijmegen, Netherlands (author)

Fluid REStriction in Heart Failure vs Liberal Fluid UPtake : Rationale and Design of the Randomized FRESH-UP Study

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • Churchill Livingstone,2022
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-190823
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-190823URI
  • https://doi.org/10.1016/j.cardfail.2022.05.015DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies|Dutch Heart Foundation [2019T100]; Radboud University Medical Centre in Nijmegen [R0005106]; Maastricht University Medical Centre [R0005106]
  • Aims: It is common practice for clinicians to advise fluid restriction in patients with heart failure (HF), but data from clinical trials are lacking. Moreover, fluid restriction is associated with thirst distress and may adversely impact quality of life (QoL). To address this gap in evidence, the Fluid REStriction in Heart failure vs liberal fluid UPtake (FRESH-UP) study was initiated. Methods: The FRESH-UP study is a randomized, controlled, open-label, multicenter trial to investigate the effects of a 3-month period of liberal fluid intake vs fluid restriction (1500 mL/day) on QoL in outpatients with chronic HF (New York Heart Association Classes II-III). The primary aim is to assess the effect on QoL after 3 months using the Overall Summary Score of the Kansas City Cardiomyopathy Questionnaire (KCCQ). Thirst distress, as assessed by the Thirst Distress Scale for patients with HF, KCCQ Clinical Summary Score, each of the KCCQ domains and clinically meaningful changes in these scores, the EQ-5D-5L, patient-reported fluid intake and safety (ie, death, HF hospitalizations) are secondary outcomes. The FRESH-UP study is registered at ClinicalTrials.gov (NCT04551729). Conclusion: The results of the FRESH-UP study will add substantially to the level of evidence concerning fluid management in chronic HF and may impact the QoL of these patients.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Beckers-Wesche, FabienneMaastricht Univ, Netherlands (author)
  • Baltussen, Lisette E. H. J. M.Radboud Univ Nijmegen, Netherlands (author)
  • Verdijk, Marjolein H. IRadboud Univ Nijmegen, Netherlands (author)
  • Bellersen, LouiseRadboud Univ Nijmegen, Netherlands (author)
  • Brunner-la Rocca, Hans-PeterMaastricht Univ, Netherlands (author)
  • Jaarsma, TinyLinköpings universitet,Avdelningen för omvårdnad och reproduktiv hälsa,Medicinska fakulteten(Swepub:liu)tinja77 (author)
  • Pisters, RonRijnstate Hosp, Netherlands (author)
  • Sanders-van Wijk, SandraZuyderland Med Ctr, Netherlands (author)
  • Rodwell, LauraRadboud Univ Nijmegen, Netherlands (author)
  • Van Royen, NielsRadboud Univ Nijmegen, Netherlands (author)
  • Gommans, D. H. FrankRadboud Univ Nijmegen, Netherlands (author)
  • Van Kimmenade, Roland R. J.Radboud Univ Nijmegen, Netherlands (author)
  • Radboud Univ Nijmegen, NetherlandsMaastricht Univ, Netherlands (creator_code:org_t)

Related titles

  • In:Journal of Cardiac Failure: Churchill Livingstone28:10, s. 1522-15301071-91641532-8414

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