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- Shruthi, N. R.Department of Medical Biotechnology, Faculty of Allied Health Sciences, Chettinad Academy of Research and Education (CARE), Chettinad Hospital and Research Institute (CHRI), Chennai, India (author)
Drug Repurposing in Cancer
- 1
- Article/chapterEnglish2023
Publisher, publication year, extent ...
- 2023-02-08
- Singapore :Springer,2023
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:liu-192116
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-192116URI
- https://doi.org/10.1007/978-981-19-5399-6_8DOI
Supplementary language notes
- Language:English
- Summary in:English
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- SwePubSwePub
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Notes
- The discovery of drug compounds has a long history in drug repurposing, notably by fortuitous findings. It has taken a new path in the creation of novel therapeutics based on existent or authorized drugs in recent years. Importantly, our knowledge of cancer biology and the related cancer hallmarks is growing. This, together with repurposing studies that use modern bioinformatics and comprehensive screening of the complete pharmacopeia, should lead to the discovery of novel medicines and targets. Furthermore, the usage of non-oncology pharmaceuticals, which make up most of our treatments, has the potential to speed up drug repurposing even further. We looked at both phenotypic-based and target-based methods of medication repurposing as well as described and assessed old non-oncology medications as prospective candidates for drug repurposing based on a broad knowledge of these principles and associated investigations of drug repurposing over the previous decade. Some of these medications successfully regulate at least one characteristic of cancer, whereas the others have a broad anticancer activity by regulating several targets through different signaling pathways, which is often brought on by various simultaneous signaling pathways. Furthermore, the emergence of computerized databases of disease gene targets, functional readouts, and clinical data encompassing inter-individual genetic variants and toxicities has allowed an alternative “big data” approach to grow at an unheard-of rate during the past decade. Here, we review the sources that are now on hand and speculate on significant upside possibilities.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
- Drug repurposing; Colorectal cancer; Target-based; Signaling pathways; Bioinformatics
Added entries (persons, corporate bodies, meetings, titles ...)
- Jain, M. SamathaDepartment of Medical Biotechnology, Faculty of Allied Health Sciences, Chettinad Academy of Research and Education (CARE), Chettinad Hospital and Research Institute (CHRI), Chennai, India (author)
- Ganesan, HarshaDepartment of Medical Biotechnology, Faculty of Allied Health Sciences, Chettinad Academy of Research and Education (CARE), Chettinad Hospital and Research Institute (CHRI), Chennai, India (author)
- Banerjee, AntaraDepartment of Medical Biotechnology, Faculty of Allied Health Sciences, Chettinad Academy of Research and Education (CARE), Chettinad Hospital and Research Institute (CHRI), Chennai, India (author)
- Zhang, HongInstitute of Medical Sciences, School of Medicine, Örebro University, Örebro, Sweden (author)
- Sun, Xiao-Feng,1959-Linköpings universitet,Medicinska fakulteten,Avdelningen för kirurgi, ortopedi och onkologi,Region Östergötland, Onkologiska kliniken US(Swepub:liu)xiasu45 (author)
- Pathak, Surajit,1977-Linköpings universitet,Medicinska fakulteten,Avdelningen för kirurgi, ortopedi och onkologi,Region Östergötland, Onkologiska kliniken US,Department of Medical Biotechnology, Faculty of Allied Health Sciences, Chettinad Academy of Research and Education (CARE), Chettinad Hospital and Research Institute (CHRI), Chennai, India(Swepub:liu)surpa77 (author)
- Department of Medical Biotechnology, Faculty of Allied Health Sciences, Chettinad Academy of Research and Education (CARE), Chettinad Hospital and Research Institute (CHRI), Chennai, IndiaInstitute of Medical Sciences, School of Medicine, Örebro University, Örebro, Sweden (creator_code:org_t)
Related titles
- In:Drug Repurposing for Emerging Infectious Diseases and CancerSingapore : Springer, s. 159-17997898119539899789811953996
Internet link
- https://link.springer.com/chapter/10.1007/978-981-19-5399-6_8
- https://libris.kb.se/bib/r7ghrxvppk5knldcFind book at a swedish library/Hitta boken i ett svenskt bibliotek
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-192116
- https://doi.org/10.1007/978-981-19-5399-6_8
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