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  • Rystedt, KarinGothenburg University,Göteborgs universitet,University of Gothenburg,Sahlgrenska Academy,CARe - Centrum för antibiotikaresistensforskning,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Centre for antibiotic resistance research, CARe,Institute of Medicine, School of Public Health and Community Medicine (författare)

Effects of penicillin V on the faecal microbiota in patients with pharyngotonsillitis-an observational study

  • Artikel/kapitelEngelska2022

Förlag, utgivningsår, omfång ...

  • 2023-02-16
  • OXFORD UNIV PRESS,2022
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:liu-192360
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-192360URI
  • https://doi.org/10.1093/jacamr/dlad006DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:236816747URI
  • https://lup.lub.lu.se/record/62cadd1b-94b2-4609-bce2-2ad2259856bdURI
  • https://gup.ub.gu.se/publication/324664URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agencies|Public Health Agency of Sweden; Healthcare Committee, Region Vaestra Goetaland; Axel Linders Foundation; Skaraborg Institute [19/1039]
  • Background The intestinal microbiota functions as a reservoir of antibiotic resistance. Objectives To evaluate penicillin V (phenoxymethylpenicillin) effects on the faecal microbiota with focus on beta-lactam resistance. Methods We included 31 primary care patients with group A streptococcal pharyngotonsillitis treated with penicillin V for 5 (800 mg x 4) or 10 days (1000 mg x 3). Twenty-nine patients contributed with three faecal swab samples each. The faecal specimens were collected at the start of penicillin V treatment, after the last dose and at follow-up 7-9 days after completed treatment. Samples were inoculated semiquantitatively on selective screening agar plates to study beta-lactam resistance, species shifts among Enterobacterales and enterococci, and colonization with Candida spp. and Clostridioides difficile. Representative colonies were identified using MALDI-TOF. Results were analysed by non-parametric statistical methods. Results An increase in the proportion of patients colonized with ampicillin-resistant Enterobacterales, from 52% to 86% (P = 0.007), and Enterobacterales with decreased susceptibility to third-generation cephalosporins, from 32% to 52% (P = 0.034), was observed between the first and second samples. This increase was no longer significant at follow-up. New colonization with ampicillin-resistant Enterobacterales species and non-Enterobacterales Gram-negative species was observed, and persisted at follow-up. Conclusions Following treatment with penicillin V, we observed decreased susceptibility to ampicillin and third-generation cephalosporins, and prolonged colonization with non-Escherichia coli Gram-negative species. These findings challenge the perception that penicillin V has limited ecological effect on the intestinal microbiota, and emphasizes the importance of avoiding even narrow-spectrum antimicrobials when possible.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Edquist, PetraPubl Hlth Agcy Sweden PHAS, Sweden,Public Health Agency of Sweden (författare)
  • Giske, Christian G.Karolinska Institute,Karolinska Institutet,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden,Karolinska University Hospital (författare)
  • Hedin, KatarinaLinköping University,Lund University,Lunds universitet,Linköpings universitet,Avdelningen för prevention, rehabilitering och nära vård,Medicinska fakulteten,Lund Univ, Sweden; Futurum, Region Jönköping County, Sweden,Allmänmedicin och samhällsmedicin,Forskargrupper vid Lunds universitet,Family Medicine and Community Medicine,Lund University Research Groups(Swepub:lu)smim-khe (författare)
  • Tyrstrup, MiaLund University,Lunds universitet,Allmänmedicin och samhällsmedicin,Forskargrupper vid Lunds universitet,Family Medicine and Community Medicine,Lund University Research Groups(Swepub:lu)med-mty (författare)
  • Stahlgren, Gunilla SkoogPubl Hlth Agcy Sweden PHAS, Sweden,Public Health Agency of Sweden (författare)
  • Sundvall, Pär-DanielGothenburg University,Göteborgs universitet,University of Gothenburg,Sahlgrenska Academy,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,CARe - Centrum för antibiotikaresistensforskning,Institute of Medicine, School of Public Health and Community Medicine,Centre for antibiotic resistance research, CARe(Swepub:gu)xsupar (författare)
  • Edlund, CharlottaPubl Hlth Agcy Sweden PHAS, Sweden,Public Health Agency of Sweden (författare)
  • University of GothenburgSahlgrenska Academy (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:JAC - Antimicrobial Resistance: OXFORD UNIV PRESS5:12632-1823

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