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Therapeutic Potenti...
Therapeutic Potential of Zeolites/Vitamin B12 Nanocomposite on Complete Freunds Adjuvant-Induced Arthritis as a Bone Disorder: In Vivo Study and Bio-Molecular Investigations
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- Belal, Amany (författare)
- Taif Univ, Saudi Arabia
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- Mahmoud, Rehab (författare)
- Beni Suef Univ, Egypt
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- Taha, Mohamed (författare)
- Beni Suef Univ, Egypt
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- Halfaya, Fatma Mohamed (författare)
- Beni Suef Univ, Egypt
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- Hassaballa, Ahmed (författare)
- Wayne State Univ, MI 48202 USA; ZeroHarm LC, MI 48333 USA
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- Elbanna, Esraa Salah (författare)
- Beni Suef Univ, Egypt
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- Khaled, Esraa (författare)
- Beni Suef Univ, Egypt
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- Farghali, Ahmed (författare)
- Beni Suef Univ, Egypt
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- Abo El-Ela, Fatma I. (författare)
- Beni Suef Univ, Egypt
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- Mahgoub, Samar M. (författare)
- Beni Suef Univ, Egypt
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- Ghoneim, Mohammed M. (författare)
- AlMaarefa Univ, Saudi Arabia; Al Azhar Univ, Egypt
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- Zaky Khalifa, Mohamed Yassin Zaky (författare)
- Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US,Beni Suef Univ, Egypt
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(creator_code:org_t)
- 2023-02-13
- 2023
- Engelska.
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Ingår i: Pharmaceuticals. - : MDPI. - 1424-8247. ; 16:2
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Rheumatoid arthritis (RA) is a long-term autoimmune disease. As nanotechnology has advanced, a growing number of nanodrugs have been used in the treatment of RA due to their unique physical and chemical properties. The purpose of this study was to assess the therapeutic potential of a novel zeolite/vitamin B12 nanocomposite (Nano ZT/Vit B12) formulation in complete Freunds adjuvant (CFA)-induced arthritis. The newly synthesized Nano ZT/Vit B12 was fully characterized using various techniques such as XRD, FT-IR, BET analysis, HERTEM, SEM, practical size, zeta potential, XRF, and EDX. The anti-arthritic, anti-inflammatory, and antioxidant activities as well as the immunomodulation effect of Nano ZT/Vit B12 on the CFA rat model of arthritis were examined. Histopathologic ankle joint injuries caused by CFA intrapedal injection included synovium hyperplasia, inflammatory cell infiltration, and extensive cartilage deterioration. The arthritic rats Nano ZT/Vit B12 supplementation significantly improved these effects. Furthermore, in arthritic rats, Nano ZT/Vit B12 significantly reduced serum levels of RF and CRP, as well as the levels of IL-1 beta, TNF-alpha, IL-17, and ADAMTS-5, while increasing IL-4 and TIMP-3 levels. Nano-ZT/Vit B12 significantly declined the LPO level and increased antioxidant activities, such as GSH content and GST activity, in the arthritic rats. In arthritic rats, Nano ZT/Vit B12 also reduced TGF-beta mRNA gene expression and MMP-13 protein levels. Collectively, Nano ZT/Vit B12 seems to have anti-arthritic, anti-inflammatory, and antioxidant properties, making it a promising option for RA in the future.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Nyckelord
- bone disability research; rheumatoid arthritis; bone disorders; Nano ZT; Vit B12; nanocomposites; oxidative stress; inflammation
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Belal, Amany
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Mahmoud, Rehab
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Taha, Mohamed
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Halfaya, Fatma M ...
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Hassaballa, Ahme ...
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Elbanna, Esraa S ...
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Khaled, Esraa
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Farghali, Ahmed
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Abo El-Ela, Fatm ...
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Mahgoub, Samar M ...
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Ghoneim, Mohamme ...
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Zaky Khalifa, Mo ...
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