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A Novel Hydroxyapat...
A Novel Hydroxyapatite/Vitamin B-12 Nanoformula for Treatment of Bone Damage: Preparation, Characterization, and Anti-Arthritic, Anti-Inflammatory, and Antioxidant Activities in Chemically Induced Arthritic Rats
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- Belal, Amany (författare)
- Taif Univ, Saudi Arabia
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- Mahmoud, Rehab (författare)
- Beni Suef Univ, Egypt
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- Mohamed, Eman E. (författare)
- Beni Suef Univ, Egypt
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- Farghali, Ahmed (författare)
- Beni Suef Univ, Egypt
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- El-Ela, Fatma I. Abo (författare)
- Beni Suef Univ, Egypt
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- Gamal, Amr (författare)
- Beni Suef Univ, Egypt
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- Halfaya, Fatma Mohamed (författare)
- Beni Suef Univ, Egypt
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- Khaled, Esraa (författare)
- Beni Suef Univ, Egypt
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- Farahat, Abdelbasset A. (författare)
- Calif Northstate Univ, CA 95757 USA; Mansoura Univ, Egypt
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- Hassan, Ahmed H. E. (författare)
- Mansoura Univ, Egypt; Kyung Hee Univ, South Korea
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- Ghoneim, Mohammed M. (författare)
- AlMaarefa Univ, Saudi Arabia
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- Taha, Mohamed (författare)
- Beni Suef Univ, Egypt
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- Zaky Khalifa, Mohamed Yassin Zaky (författare)
- Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US,Beni Suef Univ, Egypt
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(creator_code:org_t)
- MDPI, 2023
- 2023
- Engelska.
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Ingår i: Pharmaceuticals. - : MDPI. - 1424-8247. ; 16:4
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- The usage of nanomaterials for rheumatoid arthritis (RA) treatment can improve bioavailability and enable selective targeting. The current study prepares and evaluates the in vivo biological effects of a novel hydroxyapatite/vitamin B-12 nanoformula in Complete Freunds adjuvant-induced arthritis in rats. The synthesized nanoformula was characterized using XRD, FTIR, BET analysis, HERTEM, SEM, particle size, and zeta potential. We synthesized pure HAP NPs with 71.01% loading weight percentages of Vit B12 and 49 mg/g loading capacity. Loading of vitamin B-12 on hydroxyapatite was modeled by Monte Carlo simulation. Anti-arthritic, anti-inflammatory, and antioxidant effects of the prepared nanoformula were assessed. Treated arthritic rats showed lower levels of RF and CRP, IL-1 beta, TNF-alpha, IL-17, and ADAMTS-5, but higher IL-4 and TIMP-3 levels. In addition, the prepared nanoformula increased GSH content and GST antioxidant activity while decreasing LPO levels. Furthermore, it reduced the expression of TGF-beta mRNA. Histopathological examinations revealed an improvement in joint injuries through the reduction of inflammatory cell infiltration, cartilage deterioration, and bone damage caused by Complete Freunds adjuvant. These findings indicate that the anti-arthritic, antioxidant, and anti-inflammatory properties of the prepared nanoformula could be useful for the development of new anti-arthritic treatments.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Nyckelord
- bone damage; bone disability research; rheumatoid arthritis; nano-HAP; Vit B-12; anti-arthritic; antioxidant; anti-inflammatory
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Belal, Amany
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Mahmoud, Rehab
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Mohamed, Eman E.
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Farghali, Ahmed
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El-Ela, Fatma I. ...
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Gamal, Amr
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visa fler...
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Halfaya, Fatma M ...
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Khaled, Esraa
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Farahat, Abdelba ...
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Hassan, Ahmed H. ...
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Ghoneim, Mohamme ...
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Taha, Mohamed
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Zaky Khalifa, Mo ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Farmaceutiska ve ...
- Artiklar i publikationen
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Pharmaceuticals
- Av lärosätet
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Linköpings universitet