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  • Blanken, M. A. J. T.Vrije Univ, Netherlands; Vrije Univ Amsterdam Med Ctr, Netherlands (author)

Sex-specifics of ECT outcome

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • ELSEVIER,2023
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-195351
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-195351URI
  • https://doi.org/10.1016/j.jad.2022.12.144DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Objective: Electroconvulsive therapy (ECT) is the most effective treatment for patients with severe major depressive disorder (MDD). Given the known sex differences in MDD, improved knowledge may provide more sex-specific recommendations in clinical guidelines and improve outcome. In the present study we examine sex differences in ECT outcome and its predictors. Methods: Clinical data from 20 independent sites participating in the Global ECT-MRI Research Collaboration (GEMRIC) were obtained for analysis, totaling 500 patients with MDD (58.6 % women) with a mean age of 54.8 years. Severity of depression before and after ECT was assessed with validated depression scales. Remission was defined as a HAM-D score of 7 points or below after ECT. Variables associated with remission were selected based on literature (i.e. depression severity at baseline, age, duration of index episode, and presence of psychotic symptoms). Results: Remission rates of ECT were independent of sex, 48.0 % in women and 45.7 % in men (X2(1) = 0.2, p = 0.70). In the logistic regression analyses, a shorter index duration was identified as a sex-specific predictor for ECT outcome in women (X2(1) = 7.05, p = 0.01). The corresponding predictive margins did show overlapping confidence intervals for men and women. Conclusion: The evidence provided by our study suggests that ECT as a biological treatment for MDD is equally effective in women and men. A shorter duration of index episode was an additional sex-specific predictor for remission in women. Future research should establish whether the confidence intervals for the corresponding predictive margins are overlapping, as we find, or not.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Oudega, M. L.GGZ InGeest Specialized Mental Hlth Care, Netherlands; Vrije Univ, Netherlands; Vrije Univ, Netherlands; Vrije Univ Amsterdam Med Ctr, Netherlands (author)
  • Hoogendoorn, A. W.GGZ InGeest Specialized Mental Hlth Care, Netherlands; Vrije Univ, Netherlands; Vrije Univ Amsterdam Med Ctr, Netherlands (author)
  • Sonnenberg, C. S.Vrije Univ, Netherlands; GGZ Parnassia NH, Netherlands (author)
  • Rhebergen, D.Vrije Univ, Netherlands; Vrije Univ Amsterdam Med Ctr, Netherlands; GGZ Cent, Netherlands (author)
  • Klumpers, U. M. H.Vrije Univ, Netherlands; Vrije Univ, Netherlands; Vrije Univ Amsterdam Med Ctr, Netherlands (author)
  • Van Diermen, L.Psychiat Ctr Bethanie, Belgium; Univ Antwerp, Belgium; Univ Psychiat Ctr UPC Duffel, Belgium (author)
  • Birkenhager, T.Univ Antwerp, Belgium; Erasmus MC, Netherlands (author)
  • Schrijvers, D.Univ Antwerp, Belgium; Univ Psychiat Ctr UPC Duffel, Belgium (author)
  • Redlich, R.Univ Halle, Germany; Univ Munster, Germany (author)
  • Dannlowski, U.Univ Munster, Germany (author)
  • Heindel, W.Univ Munster, Germany (author)
  • Coenjaerts, M.Univ Hosp Bonn, Germany (author)
  • Nordanskog, PiaLinköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten,Region Östergötland, Psykiatriska kliniken i Linköping(Swepub:liu)piano33 (author)
  • Oltedal, L.Haukeland Hosp, Norway; Univ Bergen, Norway (author)
  • Kessler, U.Univ Bergen, Norway; Haukeland Hosp, Norway (author)
  • Frid, L. M.Univ Bergen, Norway (author)
  • Takamiya, A.Keio Univ, Japan; Katholieke Univ Leuven, Belgium (author)
  • Kishimoto, T.Keio Univ, Japan (author)
  • Jorgensen, M. B.Univ Copenhagen, Denmark; Univ Copenhagen, Denmark (author)
  • Jorgensen, A.Univ Copenhagen, Denmark; Univ Copenhagen, Denmark (author)
  • Bolwig, T.Univ Copenhagen, Denmark (author)
  • Emsell, L.Katholieke Univ Leuven, Belgium (author)
  • Sienaert, P.Katholieke Univ Leuven, Belgium (author)
  • Bouckaert, F.Katholieke Univ Leuven, Belgium (author)
  • Abbott, C. C.Univ New Mexico, NM 87131 USA (author)
  • Peran, P.Univ Toulouse, France (author)
  • Arbus, C.Univ Toulouse, France (author)
  • Yrondi, A.Univ Toulouse, France (author)
  • Kiebs, M.Univ Bonn, Germany; Univ Hosp Oldenburg, Germany (author)
  • Philipsen, A.Univ Bonn, Germany (author)
  • van Waarde, J. A.Rijnstate Arnhem, Netherlands (author)
  • Prinsen, E.Rijnstate Arnhem, Netherlands (author)
  • van Verseveld, M.Rijnstate Arnhem, Netherlands (author)
  • Van Wingen, G.Univ Amsterdam, Netherlands; Amsterdam Neurosci, Netherlands (author)
  • ten Doesschate, F.Rijnstate Arnhem, Netherlands; Univ Amsterdam, Netherlands (author)
  • Camprodon, J. A.Harvard Med Sch, MA USA (author)
  • Kritzer, M.Harvard Med Sch, MA USA (author)
  • Barbour, T.Massachusetts Gen Hosp, MA 02114 USA (author)
  • Argyelan, M.Feinstein Inst Med Res, NY USA (author)
  • Cardoner, N.Hosp Santa Creu & Sant Pau, Spain; Univ Autonoma Barcelona, Spain; Carlos III Hlth Inst, Spain (author)
  • Urretavizcaya, M.Carlos III Hlth Inst, Spain; Bellvitge Univ Hosp, Spain; Univ Barcelona, Spain (author)
  • Soriano-Mas, C.Carlos III Hlth Inst, Spain; Bellvitge Univ Hosp, Spain; Univ Barcelona, Spain (author)
  • Narr, K. L.Univ Calif Los Angeles, CA USA (author)
  • Espinoza, R. T.Univ Calif Los Angeles, CA USA (author)
  • Prudic, J.Columbia Univ, NY 10027 USA (author)
  • Rowny, S.Columbia Univ, NY 10027 USA (author)
  • van Eijndhoven, Ph.Radboud Univ Nijmegen, Netherlands (author)
  • Tendolkar, I.Radboud Univ Nijmegen, Netherlands (author)
  • Dols, A.Vrije Univ, Netherlands; Vrije Univ Amsterdam Med Ctr, Netherlands; Univ Med Ctr Utrecht, Netherlands (author)
  • Vrije Univ, Netherlands; Vrije Univ Amsterdam Med Ctr, NetherlandsGGZ InGeest Specialized Mental Hlth Care, Netherlands; Vrije Univ, Netherlands; Vrije Univ, Netherlands; Vrije Univ Amsterdam Med Ctr, Netherlands (creator_code:org_t)

Related titles

  • In:Journal of Affective Disorders: ELSEVIER326, s. 243-2480165-03271573-2517

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