Prophylactic and early outpatient treatment of COVID-19 in patients with kidney disease: considerations from the Immunonephrology Working Group of the European Renal Association (ERA-IWG)

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic led to rapid vaccine development and large global vaccination schemes. However, patients with immune-mediated kidney disease, chronic kidney diseases and kidney transplant recipients show high non-response rates to vaccination despite more than three vaccinations and, consequently, reduced viral clearance capacity when infected while receiving certain immunosuppressants, carrying an elevated risk for coronavirus disease 2019 (COVID-19)-related morbidity and mortality. SARS-CoV-2 evolution has been characterized by the emergence of novel variants and spike mutations contributing to waning efficacy of neutralizing antibodies. To this end, the therapeutic field expands from vaccination towards a combined approach of immunization, pre-exposure prophylaxis and early post-exposure treatment using direct-acting antivirals and neutralizing monoclonal antibodies to treat early in the disease course and avoid hospitalization. This expert opinion paper from the Immunonephrology Working Group of the European Renal Association (ERA-IWG) summarizes available prophylactic and/or early treatment options (i.e. neutralizing monoclonal antibodies and direct-acting antivirals) of SARS-CoV-2-infected patients with immune-mediated kidney disease, chronic kidney disease and kidney transplant recipients.

Bemelman, Frederike J.Univ Amsterdam, Netherlands (författare)
Bruchfeld, AnnetteKarolinska Institutet,Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Njurmedicinska kliniken US,Karolinska Univ Hosp, Sweden; CLINTEC Karolinska Inst, Sweden(Swepub:liu)anbru14 (författare)
Fernandez-Juarez, Gema M.Hosp Univ Fdn Alcorcon, Spain (författare)
Floege, JuergenRWTH Aachen Univ Hosp, Germany (författare)
Frangou, EleniLimassol Gen Hosp, Cyprus; Univ Nicosia, Cyprus (författare)
Goumenos, DimitriosPatras Univ Hosp, Greece (författare)
van Kooten, CeesLeiden Univ, Netherlands (författare)
Kronbichler, AndreasUniv Cambridge, England (författare)
Stevens, Kate IQueen Elizabeth Univ Hosp, Scotland (författare)
Turkmen, KultiginNecmettin Erbakan Univ, Turkiye (författare)
Wiersinga, W. JoostUniv Amsterdam, Netherlands (författare)
Anders, Hans-JoachimHosp Ludwig Maximilians Univ, Germany (författare)
Univ Amsterdam, NetherlandsAvdelningen för diagnostik och specialistmedicin (creator_code:org_t)

Ingår i:Nephrology, Dialysis and Transplantation: OXFORD UNIV PRESS38:8, s. 1807-18160931-05091460-2385

Av författaren/redakt...: Hilhorst, Marc; Bemelman, Freder ...; Bruchfeld, Annet ...; Fernandez-Juarez ...; Floege, Juergen; Frangou, Eleni; visa fler...; Goumenos, Dimitr ...; van Kooten, Cees; Kronbichler, And ...; Stevens, Kate I; Turkmen, Kultigi ...; Wiersinga, W. Jo ...; Anders, Hans-Joa ...; visa färre...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Urologi och njur ...

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