Amyloid Deposition in Transplanted Human Pancreatic Islets: A Conceivable Cause of Their Long-Term Failure

Andersson, ArneUppsala universitet,Institutionen för medicinsk cellbiologi (author)

Amyloid Deposition in Transplanted Human Pancreatic Islets : A Conceivable Cause of Their Long-Term Failure

Original Publication: Arne Andersson, Sara Bohman, L A Hakan Borg, Johan Paulsson, Sebastian Schultz, Gunilla Westermark and Per Westermark, Amyloid Deposition in Transplanted Human Pancreatic Islets: A Conceivable Cause of Their Long-Term Failure, 2008, EXPERIMENTAL DIABETES RESEARCH, (2008), 562985. http://dx.doi.org/10.1155/2008/562985 Copyright: Authors
Following the encouraging report of the Edmonton group, there was a rejuvenation of the islet transplantation field. After that, more pessimistic views spread when long-term results of the clinical outcome were published. A progressive loss of the beta-cell function meant that almost all patients were back on insulin therapy after 5 years. More than 10 years ago, we demonstrated that amyloid deposits rapidly formed in human islets and in mouse islets transgenic for human IAPP when grafted into nude mice. It is, therefore, conceivable to consider amyloid formation as one potential candidate for the long-term failure. The present paper reviews attempts in our laboratories to elucidate the dynamics of and mechanisms behind the formation of amyloid in transplanted islets with special emphasis on the impact of long-term hyperglycemia.

Bohman, SaraUppsala universitet,Institutionen för medicinsk cellbiologi(Swepub:uu)saboh254 (author)
Borg, L A HakanUppsala University (author)
Paulsson, JohanLinköpings universitet,Cellbiologi,Hälsouniversitetet(Swepub:liu)johpa34 (author)
Schultz, SebastianLinköpings universitet,Cellbiologi,Hälsouniversitetet(Swepub:liu)sebsc19 (author)
Westermark, GunillaUppsala universitet,Linköpings universitet,Cellbiologi,Hälsouniversitetet,Institutionen för medicinsk cellbiologi(Swepub:uu)gunwe105 (author)
Westermark, PerUppsala universitet,Institutionen för genetik och patologi(Swepub:uu)perweste (author)
Uppsala universitetInstitutionen för medicinsk cellbiologi (creator_code:org_t)

By the author/editor: Andersson, Arne; Bohman, Sara; Borg, L A Hakan; Paulsson, Johan; Schultz, Sebasti ...; Westermark, Guni ...; show more...; Westermark, Per; show less...

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