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Hazardous drinking ...
Hazardous drinking and alcohol use disorders
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- MacKillop, James (författare)
- McMaster Univ, Canada; St Josephs Healthcare Hamilton, Canada; Homewood Res Inst, Canada
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- Agabio, Roberta (författare)
- Univ Cagliari, Italy; CNR, Italy
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- Ewing, Sarah W. Feldstein W. (författare)
- Univ Rhode Isl, RI USA; Aarhus Univ, Denmark
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- Heilig, Markus (författare)
- Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten,Region Östergötland, Psykiatriska kliniken i Linköping
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- Kelly, John F. (författare)
- Massachusetts Gen Hosp, MA USA; Massachusetts Gen Hosp, MA USA; Harvard Med Sch, MA USA
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- Leggio, Lorenzo (författare)
- Natl Inst Alcohol Abuse & Alcoholism, MD USA; Natl Inst Drug Abuse, MD USA
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- Lingford-Hughes, Anne (författare)
- Imperial Coll London, England; Cent North West London NHS Fdn Trust, England
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- Palmer, Abraham A. (författare)
- Univ Calif San Diego, CA USA; Univ Calif San Diego, CA USA
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- Parry, Charles D. (författare)
- South African Med Res Council, South Africa; Stellenbosch Univ, South Africa
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- Ray, Lara (författare)
- Univ Calif Los Angeles, CA USA
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- Rehm, Juergen (författare)
- Ctr Addict & Mental Hlth, Canada; Univ Toronto UofT, Canada
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(creator_code:org_t)
- 2022-12-22
- 2022
- Engelska.
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Ingår i: NATURE REVIEWS DISEASE PRIMERS. - : NATURE PORTFOLIO. - 2056-676X. ; 8:1
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Alcohol is one of the most widely consumed psychoactive drugs globally. Hazardous drinking, defined by quantity and frequency of consumption, is associated with acute and chronic morbidity. Alcohol use disorders (AUDs) are psychiatric syndromes characterized by impaired control over drinking and other symptoms. Contemporary aetiological perspectives on AUDs apply a biopsychosocial framework that emphasizes the interplay of genetics, neurobiology, psychology, and an individuals social and societal context. There is strong evidence that AUDs are genetically influenced, but with a complex polygenic architecture. Likewise, there is robust evidence for environmental influences, such as adverse childhood exposures and maladaptive developmental trajectories. Well-established biological and psychological determinants of AUDs include neuroadaptive changes following persistent use, differences in brain structure and function, and motivational determinants including overvaluation of alcohol reinforcement, acute effects of environmental triggers and stress, elevations in multiple facets of impulsivity, and lack of alternative reinforcers. Social factors include bidirectional roles of social networks and sociocultural influences, such as public health control strategies and social determinants of health. An array of evidence-based approaches for reducing alcohol harms are available, including screening, pharmacotherapies, psychological interventions and policy strategies, but are substantially underused. Priorities for the field include translating advances in basic biobehavioural research into novel clinical applications and, in turn, promoting widespread implementation of evidence-based clinical approaches in practice and health-care systems.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Beroendelära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Substance Abuse (hsv//eng)
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MacKillop, James
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Agabio, Roberta
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Ewing, Sarah W. ...
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Heilig, Markus
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Kelly, John F.
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Leggio, Lorenzo
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Lingford-Hughes, ...
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Palmer, Abraham ...
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Parry, Charles D ...
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Ray, Lara
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Rehm, Juergen
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- MEDICIN OCH HÄLSOVETENSKAP
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Linköpings universitet