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- Ahmad, AwaisLinköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Region Östergötland, Klinisk immunologi och transfusionsmedicin (author)
Doubtful Clinical Value of Subtyping Anti-U1-RNP Antibodies Regarding the RNP-70 kDa Antigen in Sera of Patients with Systemic Lupus Erythematosus
- Article/chapterEnglish2023
Publisher, publication year, extent ...
- MDPI,2023
- electronicrdacarrier
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- LIBRIS-ID:oai:DiVA.org:liu-196857
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-196857URI
- https://doi.org/10.3390/ijms241210398DOI
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- Language:English
- Summary in:English
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- The detection of antinuclear antibodies is central to the diagnosis and prognosis of systemic lupus erythematosus (SLE), primary Sjogrens syndrome (pSS) and mixed connective tissue disease (MCTD). Anti-U1-RNP and anti-RNP70 antibodies were assayed in the sera of patients with SLE (n = 114), pSS (n = 54) and MCTD (n = 12). In the SLE group, 34/114 (30%) were anti-U1-RNP positive, and 21/114 (18%) were both anti-RNP70 positive and anti-U1-RNP positive. In the MCTD group, 10/12 (83%) were anti-U1-RNP positive, and 9/12 (75%) were anti-RNP70 positive. Only one individual with pSS was antibody positive (for both anti-U1-RNP and anti-RNP70). All anti-RNP70-positive samples were also anti-U1-RNP positive. Anti-U1-RNP-positive subjects with SLE were younger (p < 0.0001); showed lower concentrations of complement protein 3 (p = 0.03); had lower eosinophil (p = 0.0005), lymphocyte (p = 0.006) and monocyte (p = 0.03) counts; and had accrued less organ damage (p = 0.006) than the anti-U1-RNP-negative SLE patients. However, we observed no significant clinical or laboratory parameter differences between the anti-U1-RNP-positive individuals with/without anti-RNP70 in the SLE group. In conclusion, anti-RNP70 antibodies are not exclusive to MCTD but are rarely detected in pSS and healthy individuals. In SLE, anti-U1-RNP antibodies are associated with a clinical phenotype that resembles MCTD, with hematologic involvement and less damage accrual. Based on our results, the clinical value of subtyping anti-RNP70 in anti-U1-RNP-positive sera appears to be of limited value.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Odontologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Dentistry hsv//eng
- autoantibodies; mixed connective tissue disease; primary Sjogrens syndrome; small nuclear ribonucleoprotein antibodies; systemic lupus erythematosus
Added entries (persons, corporate bodies, meetings, titles ...)
- Brylid, AndreLinköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Region Östergötland, Klinisk immunologi och transfusionsmedicin(Swepub:liu)n/a (author)
- Dahle, CharlotteLinköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Region Östergötland, Klinisk immunologi och transfusionsmedicin(Swepub:liu)chada46 (author)
- Saleh, Muna AtallahLinköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Region Östergötland, Reumatologiska kliniken i Östergötland(Swepub:liu)munsa25 (author)
- Dahlström, ÖrjanLinköpings universitet,Psykologi,Filosofiska fakulteten,Institutet för handikappvetenskap (IHV)(Swepub:liu)orjda41 (author)
- Enocsson, HelenaLinköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Region Östergötland, Reumatologiska kliniken i Östergötland(Swepub:liu)helen05 (author)
- Sjöwall, ChristopherLinköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Region Östergötland, Reumatologiska kliniken i Östergötland(Swepub:liu)chrsj93 (author)
- Linköpings universitetAvdelningen för inflammation och infektion (creator_code:org_t)
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- In:International Journal of Molecular Sciences: MDPI24:121661-65961422-0067
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