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Towards clinical br...
Towards clinical breakpoints for non-tuberculous mycobacteria-Determination of epidemiological cut off values for the Mycobacterium avium complex and Mycobacterium abscessus using broth microdilution
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- Froberg, Gabrielle (författare)
- Karolinska Institutet,Karolinska Univ Hosp, Sweden; Karolinska Inst, Sweden
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- Maurer, Florian P. (författare)
- Res Ctr Borstel, Germany; Univ Med Ctr Hamburg Eppendorf, Germany
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- Chryssanthou, Erja (författare)
- Karolinska Univ Hosp, Sweden; Karolinska Inst, Sweden
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- Fernstrom, Louise (författare)
- Lycksele Hosp, Sweden
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- Benmansour, Hanaa (författare)
- Univ Paris Cite, France
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- Boarbi, Samira (författare)
- Sciensano, Belgium
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- Mengshoel, Anne Torunn (författare)
- Norwegian Inst Publ Hlth, Norway
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- Keller, Peter Michael (författare)
- Univ Bern, Switzerland
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- Viveiros, Miguel (författare)
- Univ Nova Lisboa, Portugal
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- Machado, Diana (författare)
- Univ Nova Lisboa, Portugal
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- Fitzgibbon, Margaret M. (författare)
- St James Hosp, Ireland; Trinity Coll Dublin, Ireland
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- Mok, Simone (författare)
- St James Hosp, Ireland; Trinity Coll Dublin, Ireland
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- Werngren, Jim (författare)
- Publ Hlth Agcy Sweden, Sweden
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- Cirillo, Daniela Maria (författare)
- IRCCS San Raffaele Sci Inst, Italy
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- Alcaide, Fernando (författare)
- Univ Barcelona, Spain
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- Hyyrylainen, Hanne-Leena (författare)
- Finnish Inst Hlth & Welf, Finland
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- Aubry, Alexandra (författare)
- Sorbonne Univ, France
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- Andres, Sonke (författare)
- Res Ctr Borstel, Germany
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- Nadarajan, Darshaalini (författare)
- Res Ctr Borstel, Germany
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- Svensson, Erik (författare)
- Statens Serum Inst, Denmark
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- Turnidge, John (författare)
- Univ Adelaide, Australia
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- Giske, Christian G. (författare)
- Karolinska Institutet,Karolinska Univ Hosp, Sweden; Karolinska Inst, Sweden
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- Kahlmeter, Gunnar (författare)
- Cent Hosp Vaxjo, Sweden
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- Cambau, Emmanuelle (författare)
- Univ Paris Cite, France
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- van Ingen, Jakko (författare)
- Radboud Univ Nijmegen, Netherlands
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- Schön, Thomas (författare)
- Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Region Östergötland, Infektionskliniken i Östergötland,Kalmar Cty Hosp, Sweden
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(creator_code:org_t)
- ELSEVIER SCI LTD, 2023
- 2023
- Engelska.
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Ingår i: Clinical Microbiology and Infection. - : ELSEVIER SCI LTD. - 1198-743X .- 1469-0691. ; 29:6, s. 758-764
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Objective: For non-tuberculous mycobacteria (NTM), minimum inhibitory concentration (MIC) distri-butions of wild-type isolates have not been systematically evaluated despite their importance for establishing antimicrobial susceptibility testing (AST) breakpoints.Methods: We gathered MIC distributions for drugs used against the Mycobacterium avium complex (MAC) and Mycobacterium abscessus (MAB) obtained by commercial broth microdilution (SLOMYCOI and RAPMYCOI) from 12 laboratories. Epidemiological cut-off values (ECOFFs) and tentative ECOFFs (TEC-OFFs) were determined by EUCAST methodology including quality control (QC) strains.Results: The clarithromycin ECOFF was 16 mg/L for M. avium (n = 1271) whereas TECOFFs were 8 mg/L for M. intracellulare (n = 415) and 1 mg/L for MAB (n = 1014) confirmed by analysing MAB subspecies without inducible macrolide resistance (n = 235). For amikacin, the ECOFFs were 64 mg/L for MAC and MAB. For moxifloxacin, the WT spanned >8 mg/L for both MAC and MAB. For linezolid, the ECOFF and TECOFF were 64 mg/L for M. avium and M. intracellulare, respectively. Current CLSI breakpoints for amikacin (16 mg/L), moxifloxacin (1 mg/L) and linezolid (8 mg/L) divided the corresponding WT dis-tributions. For QC M. avium and M. peregrinum, >= 95% of MIC values were well within recommended QC ranges.Conclusion: As a first step towards clinical breakpoints for NTM, (T)ECOFFs were defined for several antimicrobials against MAC and MAB. Broad wild-type MIC distributions indicate a need for further method refinement which is now under development within the EUCAST subcommittee for anti-mycobacterial drug susceptibility testing. In addition, we showed that several CLSI NTM breakpoints are not consistent in relation to the (T)ECOFFs. Gabrielle Froeuroberg, Clin Microbiol Infect 2023;29:758 (c) 2023 The Author(s). Published by Elsevier Ltd on behalf of European Society of Clinical Microbiology and Infectious Diseases. This is an open access article under the CC BY license (http://creativecommons. org/licenses/by/4.0/).
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Nyckelord
- Broth microdilution; Drug susceptibility testing; ECOFF; Mycobacterium; Mycobacterium abscessus; Mycobacterium avium; Non-tuberculous mycobacteria
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Froberg, Gabriel ...
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Maurer, Florian ...
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Chryssanthou, Er ...
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Fernstrom, Louis ...
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Benmansour, Hana ...
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Boarbi, Samira
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Mengshoel, Anne ...
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Keller, Peter Mi ...
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Viveiros, Miguel
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Machado, Diana
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Fitzgibbon, Marg ...
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Mok, Simone
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Werngren, Jim
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Cirillo, Daniela ...
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Alcaide, Fernand ...
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Hyyrylainen, Han ...
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Aubry, Alexandra
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Andres, Sonke
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Nadarajan, Darsh ...
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Svensson, Erik
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Turnidge, John
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Giske, Christian ...
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Kahlmeter, Gunna ...
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Cambau, Emmanuel ...
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van Ingen, Jakko
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Schön, Thomas
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