Functionality of Intron-Specific Genes and Cancer Stem Cells in the Progression of Colorectal Cancer

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Gopi, JananiFaculty of Allied Health Sciences, Chettinad Academy of Research and Education, Chettinad Hospital and Research Institute (CHRI), India (författare)

Functionality of Intron-Specific Genes and Cancer Stem Cells in the Progression of Colorectal Cancer

Artikel/kapitelEngelska2020

Förlag, utgivningsår, omfång ...

2020-10-18
Singapore :Springer,2020
printrdacarrier

Nummerbeteckningar

LIBRIS-ID:oai:DiVA.org:liu-197123
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-197123URI
https://doi.org/10.1007/978-981-15-5120-8_13DOI

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Språk:engelska
Sammanfattning på:engelska

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Ämneskategori:kap swepub-publicationtype

Anmärkningar

This review article deals with comprehensive information about the evolutionary history of introns with their localization and functions in the gene transcripts of colorectal cancer precisely. In this way, the major breakthrough in the molecular biology discipline was the discovery of introns by Richard Robert and Phil Sharp in 1977. Firstly, noncoding regions are recognized by various assortments of regulatory ncRNA sequences such as circular RNA, telomere-associated RNA, small nuclear RNA, Piwi-interacting RNA, small interfering RNA, small nucleolar RNA, microRNA, and long noncoding RNA. Fortunately, splicing process of mRNA strand deals with the excision of introns via spliceosomal proteins into mature mRNA which is witnessed only in eukaryotic organisms and devoid of the splicing machinery components in the prokaryotic organisms. The major focal point relies on intronic genes mainly involved in the progression of colorectal cancer with preliminary information. An alternative splicing process takes place in mRNA that implicates in intron retention leading to varied gene expression in cells and tissues and their promotion in colorectal cancer. Therefore, colorectal cancer-associated diseases have paved the way to know more about the intronic genes mainly concentrated among them in the progression of the related diseases. Hence, the focus of the researchers is toward the fascinating cellular and molecular biology aspects of the regulatory intronic sequences known to enhance as well as repress particular gene expression in tumor microenvironment of colorectal cancer by analyzing the genome and proteome levels for the betterment of human kind that is intended for various therapeutic purposes.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
Introns (noncoding sequences); mRNA ; Spliceosomal proteins; Alternate splicing process; Intron retention; Colorectal cancer

Biuppslag (personer, institutioner, konferenser, titlar ...)

Gopinath, MadhumalaFaculty of Allied Health Sciences, Chettinad Academy of Research and Education, Chettinad Hospital and Research Institute (CHRI), India (författare)
Sun, Xiao-Feng,1959-Linköpings universitet,Medicinska fakulteten,Avdelningen för kirurgi, ortopedi och onkologi,Region Östergötland, Onkologiska kliniken US(Swepub:liu)xiasu45 (författare)
Pathak, SurajitFaculty of Allied Health Sciences, Chettinad Academy of Research and Education, Chettinad Hospital and Research Institute (CHRI), India (författare)
Banerjee, AntaraFaculty of Allied Health Sciences, Chettinad Academy of Research and Education, Chettinad Hospital and Research Institute (CHRI), India (författare)
Faculty of Allied Health Sciences, Chettinad Academy of Research and Education, Chettinad Hospital and Research Institute (CHRI), IndiaMedicinska fakulteten (creator_code:org_t)

Sammanhörande titlar

Ingår i:Cancer Stem Cells: New Horizons in Cancer TherapiesSingapore : Springer, s. 223-23997898115511929789811551208

Internetlänk

https://rdcu.be/dkg9XLink to fulltext
https://libris.kb.se/bib/w85qqpx1t7d1qs5cFind book at a swedish library/Hitta boken i ett svenskt bibliotek
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-197123
https://doi.org/10.1007/978-981-15-5120-8_13

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Cancer Stem Cells: New Horizons in Cancer Therapies (Sök värdpublikationen i LIBRIS)

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Av författaren/redakt...: Gopi, Janani; Gopinath, Madhum ...; Sun, Xiao-Feng, ...; Pathak, Surajit; Banerjee, Antara

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Cancer och onkol ...

Artiklar i publikationen: Cancer Stem Cell ...

Av lärosätet: Linköpings universitet

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