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VEGF-B prevents exc...
VEGF-B prevents excessive angiogenesis by inhibiting FGF2/FGFR1 pathway
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- Lee, Chunsik (author)
- Sun Yat Sen Univ, Peoples R China; Guangdong Prov Key Lab Ophthalmol & Visual Sci, Peoples R China
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- Chen, Rongyuan (author)
- Sun Yat Sen Univ, Peoples R China; Guangdong Prov Key Lab Ophthalmol & Visual Sci, Peoples R China
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- Sun, Guangli (author)
- Nanjing Med Univ, Peoples R China
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- Liu, Xialin (author)
- Sun Yat Sen Univ, Peoples R China; Guangdong Prov Key Lab Ophthalmol & Visual Sci, Peoples R China
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- Lin, Xianchai (author)
- Sun Yat Sen Univ, Peoples R China; Guangdong Prov Key Lab Ophthalmol & Visual Sci, Peoples R China
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- He, Chang (author)
- Sun Yat Sen Univ, Peoples R China; Guangdong Prov Key Lab Ophthalmol & Visual Sci, Peoples R China
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- Xing, Liying (author)
- Sun Yat Sen Univ, Peoples R China; Guangdong Prov Key Lab Ophthalmol & Visual Sci, Peoples R China; Guangzhou Med Univ, Peoples R China
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- Liu, Lixian (author)
- Sun Yat Sen Univ, Peoples R China; Guangdong Prov Key Lab Ophthalmol & Visual Sci, Peoples R China; Jinan Univ, Peoples R China
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- Jensen, Lasse (author)
- Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Klinisk farmakologi
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- Kumar, Anil (author)
- Sun Yat Sen Univ, Peoples R China; Guangdong Prov Key Lab Ophthalmol & Visual Sci, Peoples R China
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- Langer, Harald F. (author)
- Heidelberg Univ, Germany; DZHK German Res Ctr Cardiovasc Res, Germany; Heidelberg Univ, Germany
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- Ren, Xiangrong (author)
- Sun Yat Sen Univ, Peoples R China; Guangdong Prov Key Lab Ophthalmol & Visual Sci, Peoples R China
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- Zhang, Jianing (author)
- Sun Yat Sen Univ, Peoples R China; Guangdong Prov Key Lab Ophthalmol & Visual Sci, Peoples R China
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- Huang, Lijuan (author)
- Sun Yat Sen Univ, Peoples R China; Guangdong Prov Key Lab Ophthalmol & Visual Sci, Peoples R China
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- Yin, Xiangke (author)
- Sun Yat Sen Univ, Peoples R China; Guangdong Prov Key Lab Ophthalmol & Visual Sci, Peoples R China
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- Kim, JongKyong (author)
- Sun Yat Sen Univ, Peoples R China; Guangdong Prov Key Lab Ophthalmol & Visual Sci, Peoples R China
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- Zhu, Juanhua (author)
- Sun Yat Sen Univ, Peoples R China; Guangdong Prov Key Lab Ophthalmol & Visual Sci, Peoples R China
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- Huang, Guanqun (author)
- Sun Yat Sen Univ, Peoples R China; Guangdong Prov Key Lab Ophthalmol & Visual Sci, Peoples R China
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- Li, Jiani (author)
- Sun Yat Sen Univ, Peoples R China; Guangdong Prov Key Lab Ophthalmol & Visual Sci, Peoples R China
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- Lu, Weiwei (author)
- Sun Yat Sen Univ, Peoples R China; Guangdong Prov Key Lab Ophthalmol & Visual Sci, Peoples R China
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- Chen, Wei (author)
- Sun Yat Sen Univ, Peoples R China; Guangdong Prov Key Lab Ophthalmol & Visual Sci, Peoples R China
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- Liu, Juanxi (author)
- Sun Yat Sen Univ, Peoples R China; Guangdong Prov Key Lab Ophthalmol & Visual Sci, Peoples R China
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- Hu, Jiaxin (author)
- Sun Yat Sen Univ, Peoples R China; Guangdong Prov Key Lab Ophthalmol & Visual Sci, Peoples R China
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- Sun, Qihang (author)
- Sun Yat Sen Univ, Peoples R China; Guangdong Prov Key Lab Ophthalmol & Visual Sci, Peoples R China
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- Lu, Weisi (author)
- Sun Yat Sen Univ, Peoples R China; Guangdong Prov Key Lab Ophthalmol & Visual Sci, Peoples R China
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- Fang, Lekun (author)
- Sun Yat Sen Univ, Peoples R China
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- Wang, Shasha (author)
- Sun Yat Sen Univ, Peoples R China; Guangdong Prov Key Lab Ophthalmol & Visual Sci, Peoples R China
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- Kuang, Haiqing (author)
- Sun Yat Sen Univ, Peoples R China; Guangdong Prov Key Lab Ophthalmol & Visual Sci, Peoples R China
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- Zhang, Yihan (author)
- Fudan Univ, Peoples R China; Shanghai Key Lab Visual Impairment & Restorat, Peoples R China
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- Tian, Geng (author)
- Binzhou Med Univ, Peoples R China
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- Mi, Jia (author)
- Binzhou Med Univ, Peoples R China
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- Kang, Bi-Ang (author)
- Sun Yat Sen Univ, Peoples R China
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- Narazaki, Masashi (author)
- Osaka Univ, Japan
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- Prodeus, Aaron (author)
- Sunnybrook Res Inst, Canada
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- Schoonjans, Luc (author)
- Katholieke Univ Leuven, Belgium; VIB, Belgium
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- Ornitz, David M. (author)
- Washington Univ, MO 63110 USA
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- Gariepy, Jean (author)
- Sunnybrook Res Inst, Canada
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- Eelen, Guy (author)
- Katholieke Univ Leuven, Belgium; VIB, Belgium
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- Dewerchin, Mieke (author)
- Katholieke Univ Leuven, Belgium; VIB, Belgium
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- Yang, Yunlong (author)
- Karolinska Institutet,Fudan Univ, Peoples R China
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- Ou, Jing-Song (author)
- Sun Yat Sen Univ, Peoples R China
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- Mora, Antonio (author)
- Guangzhou Med Univ & Guangzhou Inst Biomed & Hlth, Peoples R China
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- Yao, Jin (author)
- Nanjing Med Univ, Peoples R China
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- Zhao, Chen (author)
- Fudan Univ, Peoples R China; Shanghai Key Lab Visual Impairment & Restorat, Peoples R China
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- Liu, Yizhi (author)
- Sun Yat Sen Univ, Peoples R China; Guangdong Prov Key Lab Ophthalmol & Visual Sci, Peoples R China
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- Carmeliet, Peter (author)
- Katholieke Univ Leuven, Belgium; VIB, Belgium; Aarhus Univ, Denmark; Khalifa Univ Sci & Technol, U Arab Emirates
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- Cao, Yihai (author)
- Karolinska Inst, Sweden
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- Li, Xuri (author)
- Sun Yat Sen Univ, Peoples R China; Guangdong Prov Key Lab Ophthalmol & Visual Sci, Peoples R China
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(creator_code:org_t)
- SPRINGERNATURE, 2023
- 2023
- English.
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In: SIGNAL TRANSDUCTION AND TARGETED THERAPY. - : SPRINGERNATURE. - 2095-9907 .- 2059-3635. ; 8:1
- Related links:
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Although VEGF-B was discovered as a VEGF-A homolog a long time ago, the angiogenic effect of VEGF-B remains poorly understood with limited and diverse findings from different groups. Notwithstanding, drugs that inhibit VEGF-B together with other VEGF family members are being used to treat patients with various neovascular diseases. It is therefore critical to have a better understanding of the angiogenic effect of VEGF-B and the underlying mechanisms. Using comprehensive in vitro and in vivo methods and models, we reveal here for the first time an unexpected and surprising function of VEGF-B as an endogenous inhibitor of angiogenesis by inhibiting the FGF2/FGFR1 pathway when the latter is abundantly expressed. Mechanistically, we unveil that VEGF-B binds to FGFR1, induces FGFR1/VEGFR1 complex formation, and suppresses FGF2-induced Erk activation, and inhibits FGF2-driven angiogenesis and tumor growth. Our work uncovers a previously unrecognized novel function of VEGF-B in tethering the FGF2/FGFR1 pathway. Given the anti-angiogenic nature of VEGF-B under conditions of high FGF2/FGFR1 levels, caution is warranted when modulating VEGF-B activity to treat neovascular diseases.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Lee, Chunsik
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Chen, Rongyuan
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Sun, Guangli
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Liu, Xialin
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Lin, Xianchai
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He, Chang
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show more...
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Xing, Liying
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Liu, Lixian
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Jensen, Lasse
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Kumar, Anil
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Langer, Harald F ...
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Ren, Xiangrong
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Zhang, Jianing
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Huang, Lijuan
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Yin, Xiangke
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Kim, JongKyong
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Zhu, Juanhua
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Huang, Guanqun
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Li, Jiani
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Lu, Weiwei
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Chen, Wei
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Liu, Juanxi
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Hu, Jiaxin
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Sun, Qihang
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Lu, Weisi
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Fang, Lekun
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Wang, Shasha
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Kuang, Haiqing
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Zhang, Yihan
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Tian, Geng
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Mi, Jia
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Kang, Bi-Ang
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Narazaki, Masash ...
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Prodeus, Aaron
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Schoonjans, Luc
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Ornitz, David M.
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Gariepy, Jean
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Eelen, Guy
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Dewerchin, Mieke
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Yang, Yunlong
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Ou, Jing-Song
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Mora, Antonio
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Yao, Jin
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Zhao, Chen
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Liu, Yizhi
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Carmeliet, Peter
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Cao, Yihai
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Li, Xuri
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Pharmacology and ...
- Articles in the publication
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SIGNAL TRANSDUCT ...
- By the university
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Linköping University
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Karolinska Institutet