All-cause and cause-specific mortality among people with bipolar disorder: a large-scale systematic review and meta-analysis

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Sökning: id:"swepub:oai:DiVA.org:liu-197546" > All-cause and cause...

1 av 1
Föregående post
Nästa post
Till träfflistan

Biazus, Tais BoeiraUniv Sao Paulo, Brazil (författare)

All-cause and cause-specific mortality among people with bipolar disorder: a large-scale systematic review and meta-analysis

Artikel/kapitelEngelska2023

Förlag, utgivningsår, omfång ...

SPRINGERNATURE,2023
electronicrdacarrier

Nummerbeteckningar

LIBRIS-ID:oai:DiVA.org:liu-197546
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-197546URI
https://doi.org/10.1038/s41380-023-02109-9DOI

Kompletterande språkuppgifter

Språk:engelska
Sammanfattning på:engelska

Ingår i deldatabas

SwePubSwePub

Klassifikation

Ämneskategori:ref swepub-contenttype
Ämneskategori:for swepub-publicationtype

Anmärkningar

Funding Agencies|CAPES [88887.475730/2020-00]; Baszucki Brain Research Fund
ObjectiveBipolar disorder (BD) is associated with premature mortality. All-cause and specific mortality risks in this population remain unclear, and more studies are still needed to further understand this issue and guide individual and public strategies to prevent mortality in bipolar disorder Thus, a systematic review and meta-analysis of studies assessing mortality risk in people with BD versus the general population was conducted. The primary outcome was all-cause mortality, whilst secondary outcomes were mortality due to suicide, natural, unnatural, and specific-causes mortality.ResultsFifty-seven studies were included (BD; n = 678,353). All-cause mortality was increased in people with BD (RR = 2.02, 95% CI: 1.89-2.16, k = 39). Specific-cause mortality was highest for suicide (RR = 11.69, 95% CI: 9.22-14.81, k = 25). Risk of death due to unnatural causes (RR = 7.29, 95% CI: 6.41-8.28, k = 17) and natural causes (RR = 1.90, 95% CI: 1.75-2.06, k = 17) were also increased. Among specific natural causes analyzed, infectious causes had the higher RR (RR = 4,38, 95%CI: 1.5-12.69, k = 3), but the analysis was limited by the inclusion of few studies. Mortality risk due to respiratory (RR = 3.18, 95% CI: 2.55-3.96, k = 6), cardiovascular (RR = 1.76, 95% CI: 1.53-2.01, k = 27), and cerebrovascular (RR = 1.57, 95% CI: 1.34-1.84, k = 13) causes were increased as well. No difference was identified in mortality by cancer (RR = 0.99, 95% CI: 0.88-1.11, k = 16). Subgroup analyses and meta-regression did not affect the findings.ConclusionResults presented in this meta-analysis show that risk of premature death in BD is not only due to suicide and unnatural causes, but somatic comorbidities are also implicated. Not only the prevention of suicide, but also the promotion of physical health and the prevention of physical conditions in individuals with BD may mitigate the premature mortality in this population. Notwithstanding this is to our knowledge the largest synthesis of evidence on BD-related mortality, further well-designed studies are still warranted to inform this field.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Psykiatri hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Psychiatry hsv//eng

Biuppslag (personer, institutioner, konferenser, titlar ...)

Beraldi, Gabriel HenriqueUniv Sao Paulo, Brazil (författare)
Tokeshi, LucasUniv Sao Paulo, Brazil (författare)
Rotenberg, Luisa de SiqueiraUniv Sao Paulo, Brazil (författare)
Dragioti, ElenaLinköpings universitet,Avdelningen för prevention, rehabilitering och nära vård,Medicinska fakulteten,Region Östergötland, Smärt och rehabiliteringscentrum,Univ Ioannina, Greece(Swepub:liu)eledr71 (författare)
Carvalho, Andre F.Deakin Univ, Australia (författare)
Solmi, MarcoUniv Ottawa, Canada; Charite, Germany (författare)
Lafer, BenyUniv Sao Paulo, Brazil (författare)
Univ Sao Paulo, BrazilAvdelningen för prevention, rehabilitering och nära vård (creator_code:org_t)

Sammanhörande titlar

Ingår i:Molecular Psychiatry: SPRINGERNATURE28:6, s. 2508-25241359-41841476-5578

Internetlänk

Hitta via bibliotek

Molecular Psychiatry (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

1 av 1
Föregående post
Nästa post
Till träfflistan

Hitta mer i SwePub

Av författaren/redakt...: Biazus, Tais Boe ...; Beraldi, Gabriel ...; Tokeshi, Lucas; Rotenberg, Luisa ...; Dragioti, Elena; Carvalho, Andre ...; visa fler...; Solmi, Marco; Lafer, Beny; visa färre...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Psykiatri

Artiklar i publikationen: Molecular Psychi ...

Av lärosätet: Linköpings universitet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se