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  • Nordenskjöld, Anna,1969Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology (author)

Breast cancer survival and incidence of second primary cancers after 30 years in a randomized study of two versus five years of adjuvant tamoxifen therapy

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • CHURCHILL LIVINGSTONE,2023
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-197854
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-197854URI
  • https://doi.org/10.1016/j.breast.2023.07.010DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:153634600URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-520014URI
  • https://lup.lub.lu.se/record/048bb1bc-99b9-4eec-94e8-690fd8d6a68fURI
  • https://gup.ub.gu.se/publication/335373URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies|King Gustaf the Vth Jubilee Clinic Cancer Foundations in Gothenburg; Swedish governmental grants to scientists working in health care (ALF); Swedish Cancer Society; Alice Swenzon Foundation; Walter Anderssons Foundation; Onkologiska Klinikerna i Linkoping Forskningsfond Ulla and Tibor Veres award; Swedish Breast Cancer Association
  • Background: Tamoxifen is an established treatment for breast cancer, but its long-term effects on survival and on secondary cancers are not fully evaluated. Material and methods: We studied 30 years outcome of 4124 postmenopausal patients who were randomized to receive (totally) two or five years of adjuvant tamoxifen.Results: After 5 years of follow-up, when tamoxifen treatment was finished in both groups, until 15 years of follow-up, overall mortality (HR 0.80, 95% CI 0.72-0.90, p < 0.001), breast cancer mortality for all patients (HR 0.80, 95% CI 0.68-0.94, p = 0.006) and breast cancer mortality for patients with estrogen receptor positive disease (HR 0.67, 95% CI 0.55-0.83, p < 0.001) were significantly reduced in the five-year group as compared to the two-year group. After 15 years, the difference remained but did not further increase. In the five-year group, the incidence of contralateral breast cancer was gradually reduced during the entire period of observation. The incidence of lung cancer was also reduced in the five-year group. In contrast there was an increased endometrial cancer incidence in the five-year group and for those receiving 40 mg of tamoxifen this incidence was further increased.Conclusion: Three more years of tamoxifen therapy reduced the risk of breast cancer mortality. The difference was established during the first 15 years after randomization. Moreover, the incidence of contralateral breast cancer gradually decreased for 30 years. The incidence of lung cancer was reduced in the five-year group. In contrast the incidence of endometrial cancer was increased.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Fohlin, HelenaLinköping University,Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Regionalt cancercentrum,Linköping Univ, Reg Canc Ctr Southeast Sweden, Linköping, Sweden.;Linköping Univ, Dept Biomed & Clin Med, Linköping, Sweden.(Swepub:liu)helfo18 (author)
  • Rosell, JohanLinköping University,Linköpings universitet,Medicinska fakulteten,Institutionen för biomedicinska och kliniska vetenskaper,Region Östergötland, Regionalt cancercentrum,Linköping Univ, Reg Canc Ctr Southeast Sweden, Linköping, Sweden.;Linköping Univ, Dept Biomed & Clin Med, Linköping, Sweden.(Swepub:liu)johro19 (author)
  • Bengtsson, Nils-OlofUmeå Univ Hosp, Dept Oncol, Umeå, Sweden.,Norrland University Hospital (author)
  • Fornander, TommyKarolinska Institute,Karolinska Inst, Sweden (author)
  • Hatschek, ThomasKarolinska Institute,Karolinska Inst, Sweden (author)
  • Lindman, HenrikUppsala Univ Hosp, Dept Oncol, Uppsala, Sweden,Uppsala University Hospital(Swepub:uu)henrlind (author)
  • Malmström, PerLund University,Lunds universitet,Medicinsk onkologi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Medical oncology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital,Lund Univ, Sweden; Skane Univ Hosp, Sweden(Swepub:lu)onk-pma (author)
  • Rydén, LisaLund University,Lunds universitet,Bröstcancerkirurgi,Forskargrupper vid Lunds universitet,The Liquid Biopsy och Tumörprogression i Bröstcancer,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Breast Cancer Surgery,Lund University Research Groups,The Liquid Biopsy and Tumor Progression in Breast Cancer,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Lund Univ, Sweden(Swepub:lu)pat-lry (author)
  • Wallgren, Arne,1940Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology(Swepub:gu)xwalar (author)
  • Stål, OlleLinköping University,Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US,Linköping Univ, Dept Biomed & Clin Med, Linköping, Sweden.;Linköping Univ, Dept Oncol, Linköping, Sweden.(Swepub:liu)ollst87 (author)
  • Nordenskjöld, BoLinköping University,Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US,Linköping Univ, Dept Biomed & Clin Med, Linköping, Sweden.;Linköping Univ, Dept Oncol, Linköping, Sweden.(Swepub:liu)bono64 (author)
  • Göteborgs universitetInstitutionen för kliniska vetenskaper, Avdelningen för onkologi (creator_code:org_t)

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  • In:Breast: CHURCHILL LIVINGSTONE71, s. 63-680960-97761532-3080

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