Expression of calcitonin gene-related peptide in atopic dermatitis and correlation with distress

Funding Agencies|Hudfonden
BackgroundAtopic dermatitis (AD) is a chronic, inflammatory, often severely itching skin disorder. It may worsen due to stress, depression, or anxiety. Calcitonin gene-related peptide (CGRP) may be involved in inflammation signaling. CGRP has also been suggested in relation to stress, depression, and anxiety. This study aimed to investigate the expression of CGRP in the skin of patients with AD.MethodsTwenty-seven adult patients with AD, characterized with clinical and psychodemographic parameters, were investigated regarding CGRP expression in skin biopsies, using an immunohistochemical technique.ResultsThe total number of CGRP-positive nerve-like fibers was found to be higher in lesional skin than in non-lesional skin. Moreover, more inflammatory cells of dendritic shape intruded into the epidermis in lesional skin compared to non-lesional skin. Keratinocytes showing expression of CGRP were also found in lesional skin. Interestingly, the number of CGRP-positive nerve-like fibers in lesional skin correlated with depressive and anxiety scores. Correlation with depressive score was also found for round CGRP-positive inflammatory cells in the epidermis.ConclusionsCGRP may have a role in both the inflammatory process and distress, in AD.

Nordlind, KlasKarolinska Institutet,Karolinska Inst, Sweden (författare)
Johansson, BjoernKarolinska Inst, Sweden; Karolinska Inst, Sweden (författare)
Theodorsson, ElvarLinköpings universitet,Avdelningen för klinisk kemi och farmakologi,Medicinska fakulteten,Region Östergötland, Klinisk kemi(Swepub:liu)elvth65 (författare)
Holst, MikaelKarolinska Inst, Sweden (författare)
Loenndahl, LouiseKarolinska Inst, Sweden (författare)
Karolinska InstitutetKarolinska Inst, Sweden (creator_code:org_t)

Ingår i:Immunopharmacology and immunotoxicology: TAYLOR & FRANCIS LTD46:1, s. 67-720892-39731532-2513

Av författaren/redakt...: Abdelhadi, Saly; Nordlind, Klas; Johansson, Bjoer ...; Theodorsson, Elv ...; Holst, Mikael; Loenndahl, Louis ...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Dermatologi och ...

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