Sökning: WFRF:(Xu Haibo) >
Applications of Bor...
Applications of Boron Cluster Supramolecular Frameworks as Metal-Free Chemodynamic Therapy Agents for Melanoma
-
- Xu, Xiaoran (författare)
- Wuhan Univ, Peoples R China
-
- Deng, Xuefan (författare)
- Wuhan Univ, Peoples R China
-
- Li, Yi (författare)
- Wuhan Univ, Peoples R China
-
visa fler...
-
- Xia, Shiying (författare)
- Wuhan Univ, Peoples R China
-
- Baryshnikov, Glib (författare)
- Linköpings universitet,Laboratoriet för organisk elektronik,Tekniska fakulteten
-
- Bondarchuk, Sergey V. (författare)
- Bogdan Khmelnitsky Cherkasy Natl Univ, Ukraine
-
- Agren, Hans (författare)
- Uppsala Univ, Sweden
-
- Wang, Xinyu (författare)
- Wuhan Univ, Peoples R China
-
- Liu, Pan (författare)
- Wuhan Univ, Peoples R China
-
- Tan, Yujia (författare)
- Wuhan Univ, Peoples R China
-
- Huang, Tianhe (författare)
- Wuhan Univ, Peoples R China
-
- Zhang, Haibo (författare)
- Wuhan Univ, Peoples R China
-
- Wei, Yongchang (författare)
- Wuhan Univ, Peoples R China
-
visa färre...
-
(creator_code:org_t)
- 2023
- 2023
- Engelska.
-
Ingår i: Small. - : WILEY-V C H VERLAG GMBH. - 1613-6810 .- 1613-6829.
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Chemodynamic therapy (CDT) is a highly targeted approach to treat cancer since it converts hydrogen peroxide into harmful hydroxyl radicals (OH & BULL;) through Fenton or Fenton-like reactions. However, the systemic toxicity of metal-based CDT agents has limited their clinical applications. Herein, a metal-free CDT agent: 2,4,6-tri(4-pyridyl)-1,3,5-triazine (TPT)/ [closo-B12H12]2-(TPT@ B12H12) is reported. Compared to the traditional metal-based CDT agents, TPT@B12H12 is free of metal avoiding cumulative toxicity during long-term therapy. Density functional theory (DFT) calculation revealed that TPT@B12H12 decreased the activation barrier more than 3.5 times being a more effective catalyst than the Fe2+ ion (the Fenton reaction), which decreases the barrier about twice. Mechanismly, the theory calculation indicated that both [B12H12]-& BULL; and [TPT-H]2+ have the capacity to decompose hydrogen into 1O2, OH & BULL;, and O2-& BULL;. With electron paramagnetic resonance and fluorescent probes, it is confirmed that TPT@B12H12 increases the levels of 1O2, OH & BULL;, and O2-& BULL;. More importantly, TPT@B12H12 effectively suppress the melanoma growth both in vitro and in vivo through 1O2, OH & BULL;, and O2-& BULL; generation. This study specifically highlights the great clinical translational potential of TPT@B12H12 as a CDT reagent. 2,4,6-Tri(4-pyridyl)-1,3,5-triazine (TPT)/ [closo-B12H12]2-(TPT@B12H12), a metal-free chemodynamic therapy (CDT) agent, decreases the activation barrier more than 3.5 times being a more effective catalyst than the Fe2+ ion (the Fenton reaction), which decreases the barrier about twice. More importantly, TPT@B12H12 effectively suppress the melanoma growth both in vitro and in vivo through 1O2, OH & BULL;, and O2-& BULL; generation. image
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- boron cluster supramolecular frameworks; chemodynamic therapy; fenton-like catalytic activity; melanoma
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
-
Small
(Sök värdpublikationen i LIBRIS)
Till lärosätets databas
- Av författaren/redakt...
-
Xu, Xiaoran
-
Deng, Xuefan
-
Li, Yi
-
Xia, Shiying
-
Baryshnikov, Gli ...
-
Bondarchuk, Serg ...
-
visa fler...
-
Agren, Hans
-
Wang, Xinyu
-
Liu, Pan
-
Tan, Yujia
-
Huang, Tianhe
-
Zhang, Haibo
-
Wei, Yongchang
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Cancer och onkol ...
- Artiklar i publikationen
-
Small
- Av lärosätet
-
Linköpings universitet