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Association between catheter ablation of atrial fibrillation and mortality or stroke
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- Akerstrom, Finn (author)
- Karolinska Univ Hosp, Sweden; Karolinska Inst, Sweden
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- Hutter, Julie (author)
- Kerckhoff Heart & Thorax Ctr, Germany
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- Charitakis, Emmanouil (author)
- Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US
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- Tabrizi, Fariborz (author)
- Arrhythm Ctr, Sweden
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- Asaad, Fahd (author)
- Karolinska Univ Hosp, Sweden
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- Bastani, Hamid (author)
- Karolinska Univ Hosp, Sweden
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- Bourke, Tara (author)
- Karolinska Univ Hosp, Sweden; Karolinska Inst, Sweden
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- Braunschweig, Frieder (author)
- Karolinska Univ Hosp, Sweden; Karolinska Inst, Sweden
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- Drca, Nikola (author)
- Karolinska Univ Hosp, Sweden; Karolinska Inst, Sweden
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- Englund, Anders (author)
- Arrhythm Ctr, Sweden
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- Friberg, Leif (author)
- Karolinska Inst, Sweden
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- Insulander, Per (author)
- Karolinska Inst, Sweden
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- Jonsson, Anders Hassel (author)
- Linköpings universitet,Institutionen för hälsa, medicin och vård,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US
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- Kenneback, Goran (author)
- Karolinska Univ Hosp, Sweden
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- Paul-Nordin, Astrid (author)
- Karolinska Univ Hosp, Sweden; Karolinska Inst, Sweden
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- Sadigh, Bita (author)
- Karolinska Univ Hosp, Sweden
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- Saluveer, Ott (author)
- Karolinska Univ Hosp, Sweden; Karolinska Inst, Sweden
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- Saygi, Serkan (author)
- Karolinska Univ Hosp, Sweden
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- Schwieler, Jonas (author)
- Karolinska Univ Hosp, Sweden; Karolinska Inst, Sweden
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- Svennberg, Emma (author)
- Karolinska Institutet,Karolinska Univ Hosp, Sweden; Karolinska Inst, Sweden
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- Tapanainen, Jari (author)
- Danderyd Hosp, Sweden
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- Turkmen, Yusuf (author)
- Karolinska Univ Hosp, Sweden
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- Jensen-Urstad, Mats (author)
- Karolinska Univ Hosp, Sweden; Karolinska Inst, Sweden
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(creator_code:org_t)
- BMJ PUBLISHING GROUP, 2024
- 2024
- English.
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In: Heart. - : BMJ PUBLISHING GROUP. - 1355-6037 .- 1468-201X. ; 110, s. 163-169
- Related links:
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Subject headings
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- Objective Catheter ablation of atrial fibrillation effectively reduces symptomatic burden. However, its long-term effect on mortality and stroke is unclear. We investigated if patients with atrial fibrillation who undergo catheter ablation have lower risk for all-cause mortality or stroke than patients who are managed medically. Methods We retrospectively included 5628 consecutive patients who underwent first-time catheter ablation for atrial fibrillation between 2008 and 2018 at three major Swedish electrophysiology units. Control individuals with an atrial fibrillation diagnosis but without previous stroke were selected from the Swedish National Patient Register, resulting in a control group of 48 676 patients. Propensity score matching was performed to produce two cohorts of equal size (n=3955) with similar baseline characteristics. The primary endpoint was a composite of all-cause mortality or stroke. Results Patients who underwent catheter ablation were healthier (mean CHA(2)DS(2)-VASc score 1.4 +/- 1.4 vs 1.6 +/- 1.5, p<0.001), had a higher median income (288 vs 212 1000 Swedish krona [KSEK]/year, p<0.001) and had more frequently received university education (45.1% vs 28.9%, p<0.001). Mean follow-up was 4.5 +/- 2.8 years. After propensity score matching, catheter ablation was associated with lower risk for the combined primary endpoint (HR 0.58, 95% CI 0.48 to 0.69). The result was mainly driven by a decrease in all-cause mortality (HR 0.51, 95% CI 0.41 to 0.63), with stroke reduction showing a trend in favour of catheter ablation (HR 0.75, 95% CI 0.53 to 1.07). Conclusions Catheter ablation of atrial fibrillation was associated with a reduction in the primary endpoint of all-cause mortality or stroke. This result was driven by a marked reduction in all-cause mortality.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Atrial Fibrillation; Catheter Ablation; STROKE
Publication and Content Type
- ref (subject category)
- art (subject category)
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Heart
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To the university's database
- By the author/editor
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Akerstrom, Finn
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Hutter, Julie
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Charitakis, Emma ...
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Tabrizi, Faribor ...
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Asaad, Fahd
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Bastani, Hamid
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Bourke, Tara
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Braunschweig, Fr ...
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Drca, Nikola
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Englund, Anders
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Friberg, Leif
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Insulander, Per
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Jonsson, Anders ...
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Kenneback, Goran
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Paul-Nordin, Ast ...
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Sadigh, Bita
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Saluveer, Ott
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Saygi, Serkan
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Schwieler, Jonas
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Svennberg, Emma
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Tapanainen, Jari
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Turkmen, Yusuf
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Jensen-Urstad, M ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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Heart
- By the university
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Linköping University
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Karolinska Institutet