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COVID-19 outcomes i...
COVID-19 outcomes in patients with a history of immune-mediated glomerular diseases
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- Gauckler, Philipp (author)
- Med Univ Innsbruck, Austria
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- Kesenheimer, Jana S. (author)
- Univ Innsbruck, Austria
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- Geetha, Duvuru (author)
- Johns Hopkins Univ, MD USA
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- Odler, Balazs (author)
- Univ Cambridge, England; Med Univ Graz, Austria
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- Eller, Kathrin (author)
- Med Univ Graz, Austria
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- Laboux, Timothee (author)
- Univ Lille, France; Univ Lille, France
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- Alberici, Federico (author)
- Univ Brescia, Italy; Azienda Socio Sanit Territoriale ASST Spedali Civi, Italy
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- Zappa, Mattia (author)
- Univ Brescia, Italy; Azienda Socio Sanit Territoriale ASST Spedali Civi, Italy
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- Chebotareva, Natasha (author)
- Sechenov First Moscow State Med Univ, Russia
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- Moiseev, Sergey (author)
- Sechenov First Moscow State Med Univ, Russia
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- Bonilla, Marco (author)
- Northwell Hlth, NY USA
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- Jhaveri, Kenar D. (author)
- Northwell Hlth, NY USA
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- Oniszczuk, Julie (author)
- Paris East Univ, France
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- Audard, Vincent (author)
- Paris East Univ, France
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- Costa, Denise (author)
- Univ Fed Pernambuco, Brazil
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- Mastroianni-Kirsztajn, Gianna (author)
- Univ Fed Sao Paulo, Brazil
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- Bruchfeld, Annette (author)
- Karolinska Institutet,Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Njurmedicinska kliniken US,Karolinska Inst, Sweden
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- Muto, Masahiro (author)
- Juntendo Univ, Japan
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- Windpessl, Martin (author)
- Klinikum Wels Grieskirchen, Austria
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- Mayer, Gert (author)
- Med Univ Innsbruck, Austria
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- Kronbichler, Andreas (author)
- Med Univ Innsbruck, Austria; Univ Cambridge, England
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(creator_code:org_t)
- FRONTIERS MEDIA SA, 2023
- 2023
- English.
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In: Frontiers in Immunology. - : FRONTIERS MEDIA SA. - 1664-3224. ; 14
- Related links:
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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http://kipublication...
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Abstract
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- Introduction: Patients with immune-mediated glomerular diseases are considered at high risk for severe COVID-19 outcomes. However, conclusive evidence for this patient population is scarce.Methods: We created a global registry and retrospectively collected clinical data of patients with COVID-19 and a previously diagnosed immune-mediated glomerular disease to characterize specific risk factors for severe COVID-19 outcomes.Results: Fifty-nine patients with a history of immune-mediated glomerular diseases were diagnosed with COVID-19 between 01.03.2020 and 31.08.2021. Over a mean follow-up period of 24.79 +/- 18.89 days, ten patients (16.9%) developed acute kidney injury. Overall, 44.1% of patients were managed in an outpatient setting and therefore considered as having "non-severe" COVID-19, while 55.9% of patients had severe COVID-19 requiring hospitalization including worse outcomes. Comparing both groups, patients with severe COVID-19 were significantly older (53.55 +/- 17.91 versus 39.77 +/- 14.95 years, p = .003), had lower serum albumin levels at presentation (3.00 +/- 0.80 g/dL versus 3.99 +/- 0.68 g/dL, p = .016) and had a higher risk of developing acute kidney injury (27% versus 4%, p = .018). Male sex (p <.001) and ongoing intake of corticosteroids at presentation (p = .047) were also significantly associated with severe COVID-19 outcomes, while the overall use of ongoing immunosuppressive agents and glomerular disease remission status showed no significant association with the severity of COVID-19 (p = .430 and p = .326, respectively).Conclusion: Older age, male sex, ongoing intake of corticosteroids and lower serum albumin levels at presentation were identified as risk factors for severe COVID-19 outcomes in patients with a history of various immune-mediated glomerular diseases.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Keyword
- coronavirus; risk factor; autoimmune disease; kidney disease; glomerulonephritis; immunosuppression
Publication and Content Type
- ref (subject category)
- art (subject category)
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Gauckler, Philip ...
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Kesenheimer, Jan ...
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Geetha, Duvuru
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Odler, Balazs
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Eller, Kathrin
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Laboux, Timothee
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Alberici, Federi ...
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Zappa, Mattia
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Chebotareva, Nat ...
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Moiseev, Sergey
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Bonilla, Marco
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Jhaveri, Kenar D ...
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Oniszczuk, Julie
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Audard, Vincent
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Costa, Denise
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Mastroianni-Kirs ...
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Bruchfeld, Annet ...
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Muto, Masahiro
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Windpessl, Marti ...
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Mayer, Gert
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Kronbichler, And ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Microbiology in ...
- Articles in the publication
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Frontiers in Imm ...
- By the university
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Linköping University
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Karolinska Institutet