Sökning: WFRF:(Karkaby Laurice) >
Disturbed sleep is ...
Disturbed sleep is associated with reduced verbal episodic memory and entorhinal cortex volume in younger middle-aged women with risk-reducing early ovarian removal
-
- Gervais, Nicole J. (författare)
- Univ Toronto, Canada; Rotman Res Inst Baycrest Hlth Sci, Canada; Univ Groningen, Netherlands
-
- Gravelsins, Laura (författare)
- Univ Toronto, Canada
-
- Brown, Alana (författare)
- Univ Toronto, Canada
-
visa fler...
-
- Reuben, Rebekah (författare)
- Univ Toronto, Canada
-
- Perovic, Mateja (författare)
- Univ Toronto, Canada
-
- Karkaby, Laurice (författare)
- Univ Toronto, Canada
-
- Nicoll, Gina (författare)
- Univ Toronto, Canada
-
- Laird, Kazakao (författare)
- Univ Toronto, Canada
-
- Ramana, Shreeyaa (författare)
- Univ Toronto, Canada
-
- Bernardini, Marcus Q. (författare)
- Univ Hlth Network, Canada
-
- Jacobson, Michelle (författare)
- Univ Hlth Network, Canada
-
- Velsher, Lea (författare)
- North York Gen Hosp, Canada
-
- Foulkes, William (författare)
- McGill Univ, Canada; Jewish Gen Hosp, Canada
-
- Rajah, M. Natasha (författare)
- McGill Univ, Canada; McGill Univ, Canada; Toronto Metropolitan Univ, Canada
-
- Olsen, Rosanna K. (författare)
- Univ Toronto, Canada; Rotman Res Inst Baycrest Hlth Sci, Canada
-
- Grady, Cheryl (författare)
- Univ Toronto, Canada; Rotman Res Inst Baycrest Hlth Sci, Canada
-
- Einstein, Gillian (författare)
- Linköpings universitet,Tema Genus,Filosofiska fakulteten,Univ Toronto, Canada; Rotman Res Inst Baycrest Hlth Sci, Canada; Womens Coll Res Inst, Canada
-
visa färre...
-
(creator_code:org_t)
- FRONTIERS MEDIA SA, 2023
- 2023
- Engelska.
-
Ingår i: Frontiers in Endocrinology. - : FRONTIERS MEDIA SA. - 1664-2392. ; 14
- Relaterad länk:
-
https://liu.diva-por... (primary) (Raw object)
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.3...
-
visa färre...
Abstract
Ämnesord
Stäng
- Introduction: Women with early ovarian removal (<48 years) have an elevated risk for both late-life Alzheimers disease (AD) and insomnia, a modifiable risk factor. In early midlife, they also show reduced verbal episodic memory and hippocampal volume. Whether these reductions correlate with a sleep phenotype consistent with insomnia risk remains unexplored. Methods: We recruited thirty-one younger middleaged women with risk-reducing early bilateral salpingo-oophorectomy (BSO), fifteen of whom were taking estradiol-based hormone replacement therapy (BSO+ERT) and sixteen who were not (BSO). Fourteen age-matched premenopausal (AMC) and seventeen spontaneously peri-postmenopausal (SM) women who were similar to 10y older and not taking ERT were also enrolled. Overnight polysomnography recordings were collected at participants home across multiple nights (M=2.38 SEM=0.19), along with subjective sleep quality and hot flash ratings. In addition to group comparisons on sleep measures, associations with verbal episodic memory and medial temporal lobe volume were assessed. Results: Increased sleep latency and decreased sleep efficiency were observed on polysomnography recordings of those not taking ERT, consistent with insomnia symptoms. This phenotype was also observed in the older women in SM, implicating ovarian hormone loss. Further, sleep latency was associated with more forgetting on the paragraph recall task, previously shown to be altered in women with early BSO. Both increased sleep latency and reduced sleep efficiency were associated with smaller anterolateral entorhinal cortex volume. Discussion: Together, these findings confirm an association between ovarian hormone loss and insomnia symptoms, and importantly, identify an younger onset age in women with early ovarian removal, which may contribute to poorer cognitive and brain outcomes in these women.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- bilateral salpingo-oophorectomy; BRCA1/2; estradiol; sleep phenotype; verbal episodic memory; structural neuroimaging; entorhinal cortex
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Gervais, Nicole ...
-
Gravelsins, Laur ...
-
Brown, Alana
-
Reuben, Rebekah
-
Perovic, Mateja
-
Karkaby, Laurice
-
visa fler...
-
Nicoll, Gina
-
Laird, Kazakao
-
Ramana, Shreeyaa
-
Bernardini, Marc ...
-
Jacobson, Michel ...
-
Velsher, Lea
-
Foulkes, William
-
Rajah, M. Natash ...
-
Olsen, Rosanna K ...
-
Grady, Cheryl
-
Einstein, Gillia ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Endokrinologi oc ...
- Artiklar i publikationen
-
Frontiers in End ...
- Av lärosätet
-
Linköpings universitet