Performance of non-invasive tests and histology for the prediction of clinical outcomes in patients with non-alcoholic fatty liver disease: an individual participant data meta-analysis

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Sökning: WFRF:(Wiegand G.) > Performance of non-...

Performance of non-invasive tests and histology for the prediction of clinical outcomes in patients with non-alcoholic fatty liver disease: an individual participant data meta-analysis

Mozes, Ferenc E. (författare): Univ Oxford, England

Lee, Jenny A. (författare): Univ Amsterdam, Netherlands

Vali, Yasaman (författare): Univ Amsterdam, Netherlands

visa fler...

Alzoubi, Osama (författare): Univ Jordan, Jordan

Staufer, Katharina (författare): Med Univ Vienna, Austria; Med Univ Vienna, Austria

Trauner, Michael (författare): Med Univ Vienna, Austria

Paternostro, Rafael (författare): Med Univ Vienna, Austria

Stauber, Rudolf E. (författare): Med Univ Graz, Austria

Holleboom, Adriaan G. (författare): Univ Amsterdam, Netherlands

van Dijk, Anne-Marieke (författare): Univ Amsterdam, Netherlands

Mak, Anne Linde (författare): Univ Amsterdam, Netherlands

Boursier, Jerome (författare): Univ Angers, France; Ctr Hosp Univ Angers, France

Loup, Marc de Saint (författare): Ctr Hosp Univ Angers, France

Shima, Toshihide (författare): Saiseikai Suita Hosp, Japan

Bugianesi, Elisabetta (författare): Univ Turin, Italy

Gaia, Silvia (författare): Univ Turin, Italy

Armandi, Angelo (författare): Univ Turin, Italy

Lupsor-Platon, Monica (författare): Iuliu Haieganu Univ Med & Pharm, Romania

Wong, Vincent Wai-Sun (författare): Chinese Univ Hong Kong, Peoples R China

Li, Guanlin (författare): Chinese Univ Hong Kong, Peoples R China

Wong, Grace Lai-Hung (författare): Chinese Univ Hong Kong, Peoples R China

Cobbold, Jeremy (författare): Univ Oxford, England

Karlas, Thomas (författare): Univ Hosp Leipzig, Germany

Wiegand, Johannes (författare): Univ Hosp Leipzig, Germany

Sebastiani, Giada (författare): McGill Univ, Canada; McGill Univ, Canada

Tsochatzis, Emmanuel (författare): Royal Free London NHS Fdn Trust, England; UCL, England

Liguori, Antonio (författare): Royal Free London NHS Fdn Trust, England; UCL, England; Univ Cattol Sacro Cuore, Italy

Yoneda, Masato (författare): Yokohama City Univ, Japan

Nakajima, Atsushi (författare): Yokohama City Univ, Japan

Hagstrom, Hannes (författare): Karolinska Institutet

Akbari, Camilla (författare): Dept Med, Sweden

Hirooka, Masashi (författare): Ehime Univ, Japan

Chan, Wah-Kheong (författare): Univ Malaya, Malaysia

Mahadeva, Sanjiv (författare): Univ Malaya, Malaysia

Rajaram, Ruveena (författare): Univ Malaya, Malaysia

Zheng, Ming-Hua (författare): Wenzhou Med Univ, Peoples R China; Wenzhou Med Univ, Peoples R China; Key Lab Diag & Treatment Dev Chron Liver Dis Zhej, Peoples R China

George, Jacob (författare): Univ Sydney, Australia

Eslam, Mohammed (författare): Univ Sydney, Australia

Petta, Salvatore (författare): PROMISE, Italy

Pennisi, Grazia (författare): PROMISE, Italy

Vigano, Mauro (författare): ASST Papa Giovanni XXIII, Italy

Ridolfo, Sofia (författare): Univ Milan, Italy

Aithal, Guruprasad Padur (författare): Univ Nottingham, England

Palaniyappan, Naaventhan (författare): Univ Nottingham, England

Lee, Dae Ho (författare): Gachon Univ, South Korea

Ekstedt, Mattias (författare): Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Mag- tarmmedicinska kliniken

Nasr, Patrik (författare): Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Mag- tarmmedicinska kliniken

Cassinotto, Christophe (författare): Univ Hosp Montpellier, France; Univ Hosp Montpellier, France

de Ledinghen, Victor (författare): Bordeaux Univ Hosp, France; Univ Bordeaux, France

Berzigotti, Annalisa (författare): Univ Hosp Bern, Switzerland; Univ Bern, Switzerland

Mendoza, Yuly P. (författare): Univ Bern, Switzerland

Noureddin, Mazen (författare): Houston Methodist Hosp, TX USA

Truong, Emily (författare): Cedars Sinai Med Ctr, CA USA

Fournier-Poizat, Celine (författare): Echosens, France

Geier, Andreas (författare): Univ Hosp Wurzburg, Germany

Martic, Miljen (författare): Novartis Inst Biomed Res, Switzerland

Tuthill, Theresa (författare): Pfizer, MA USA

Anstee, Quentin M. (författare): Newcastle Univ, Australia; Newcastle Tyne Hosp NHS Trust, Australia

Harrison, Stephen A. (författare): Univ Oxford, England

Bossuyt, Patrick M. (författare): Univ Amsterdam, Netherlands

Pavlides, Michael (författare): Univ Oxford, England

visa färre...

(creator_code:org_t)

ELSEVIER INC, 2023
2023
Engelska.
Ingår i: The Lancet Gastroenterology & Hepatology. - : ELSEVIER INC. - 2468-1253. ; 8:8, s. 704-713

Relaterad länk:: https://urn.kb.se/re...; visa fler...; https://doi.org/10.1...; http://kipublication...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

Stäng

Background Histologically assessed liver fibrosis stage has prognostic significance in patients with non-alcoholic fatty liver disease (NAFLD) and is accepted as a surrogate endpoint in clinical trials for non-cirrhotic NAFLD. Our aim was to compare the prognostic performance of non-invasive tests with liver histology in patients with NAFLD. Methods This was an individual participant data meta-analysis of the prognostic performance of histologically assessed fibrosis stage (F0-4), liver stiffness measured by vibration-controlled transient elastography (LSM-VCTE), fibrosis-4 index (FIB-4), and NAFLD fibrosis score (NFS) in patients with NAFLD. The literature was searched for a previously published systematic review on the diagnostic accuracy of imaging and simple non-invasive tests and updated to Jan 12, 2022 for this study. Studies were identified through PubMed/MEDLINE, EMBASE, and CENTRAL, and authors were contacted for individual participant data, including outcome data, with a minimum of 12 months of follow-up. The primary outcome was a composite endpoint of all-cause mortality, hepatocellular carcinoma, liver transplantation, or cirrhosis complications (ie, ascites, variceal bleeding, hepatic encephalopathy, or progression to a MELD score >= 15). We calculated aggregated survival curves for trichotomised groups and compared them using stratified log-rank tests (histology: F0-2 vs F3 vs F4; LSM: <10 vs 10 to <20 vs >= 20 kPa; FIB-4: <1<middle dot>3 vs 1<middle dot>3 to <= 2<middle dot>67 vs >2<middle dot>67; NFS: <-1<middle dot>455 vs -1<middle dot>455 to <= 0<middle dot>676 vs >0<middle dot>676), calculated areas under the time-dependent receiver operating characteristic curves (tAUC), and performed Cox proportional-hazards regression to adjust for confounding. This study was registered with PROSPERO, CRD42022312226.Findings Of 65 eligible studies, we included data on 2518 patients with biopsy-proven NAFLD from 25 studies (1126 [44<middle dot>7%] were female, median age was 54 years [IQR 44-63), and 1161 [46<middle dot>1%] had type 2 diabetes). After a median follow-up of 57 months [IQR 33-91], the composite endpoint was observed in 145 (5<middle dot>8%) patients. Stratified log-rank tests showed significant differences between the trichotomised patient groups (p<0<middle dot>0001 for all comparisons). The tAUC at 5 years were 0<middle dot>72 (95% CI 0<middle dot>62-0<middle dot>81) for histology, 0<middle dot>76 (0<middle dot>70-0<middle dot>83) for LSM-VCTE, 0<middle dot>74 (0<middle dot>64-0<middle dot>82) for FIB-4, and 0<middle dot>70 (0<middle dot>63-0<middle dot>80) for NFS. All index tests were significant predictors of the primary outcome after adjustment for confounders in the Cox regression.Interpretation Simple non-invasive tests performed as well as histologically assessed fibrosis in predicting clinical outcomes in patients with NAFLD and could be considered as alternatives to liver biopsy in some cases.

Hitta via bibliotek

The Lancet Gastroenterology & Hepatology (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Hitta mer i SwePub

Av författaren/redakt...: Mozes, Ferenc E.; Lee, Jenny A.; Vali, Yasaman; Alzoubi, Osama; Staufer, Kathari ...; Trauner, Michael; visa fler...; Paternostro, Raf ...; Stauber, Rudolf ...; Holleboom, Adria ...; van Dijk, Anne-M ...; Mak, Anne Linde; Boursier, Jerome; Loup, Marc de Sa ...; Shima, Toshihide; Bugianesi, Elisa ...; Gaia, Silvia; Armandi, Angelo; Lupsor-Platon, M ...; Wong, Vincent Wa ...; Li, Guanlin; Wong, Grace Lai- ...; Cobbold, Jeremy; Karlas, Thomas; Wiegand, Johanne ...; Sebastiani, Giad ...; Tsochatzis, Emma ...; Liguori, Antonio; Yoneda, Masato; Nakajima, Atsush ...; Hagstrom, Hannes; Akbari, Camilla; Hirooka, Masashi; Chan, Wah-Kheong; Mahadeva, Sanjiv; Rajaram, Ruveena; Zheng, Ming-Hua; George, Jacob; Eslam, Mohammed; Petta, Salvatore; Pennisi, Grazia; Vigano, Mauro; Ridolfo, Sofia; Aithal, Gurupras ...; Palaniyappan, Na ...; Lee, Dae Ho; Ekstedt, Mattias; Nasr, Patrik; Cassinotto, Chri ...; de Ledinghen, Vi ...; Berzigotti, Anna ...; Mendoza, Yuly P.; Noureddin, Mazen; Truong, Emily; Fournier-Poizat, ...; Geier, Andreas; Martic, Miljen; Tuthill, Theresa; Anstee, Quentin ...; Harrison, Stephe ...; Bossuyt, Patrick ...; Pavlides, Michae ...; visa färre...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Gastroenterologi

Artiklar i publikationen: The Lancet Gastr ...

Av lärosätet: Linköpings universitet; Karolinska Institutet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se

Performance of non-invasive tests and histology for the prediction of clinical outcomes in patients with non-alcoholic fatty liver disease: an individual participant data meta-analysis

Ämnesord

Publikations- och innehållstyp

Hitta via bibliotek

Till lärosätets databas

Hitta mer i SwePub

Sök utanför SwePub