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  • Pavlides, MichaelUniv Oxford, England; John Radcliffe Hosp, England (author)

Liver investigation: Testing marker utility in steatohepatitis (LITMUS): Assessment & validation of imaging modality performance across the NAFLD spectrum in a prospectively recruited cohort study (the LITMUS imaging study): Study protocol

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • ELSEVIER SCIENCE INC,2023
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-199326
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-199326URI
  • https://doi.org/10.1016/j.cct.2023.107352DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies|Innovative Medicines Initiative 2 Joint Undertaking [777377]; European Union; EFPIA; Oxford NIHR Biomedical Research Centre; Newcastle NIHR Biomedical Research Centre; NIHR Senior Investigator
  • Non-alcoholic fatty liver disease (NAFLD) is the liver manifestation of the metabolic syndrome with global prevalence reaching epidemic levels. Despite the high disease burden in the population only a small proportion of those with NAFLD will develop progressive liver disease, for which there is currently no approved pharmacotherapy. Identifying those who are at risk of progressive NAFLD currently requires a liver biopsy which is problematic. Firstly, liver biopsy is invasive and therefore not appropriate for use in a condition like NAFLD that affects a large proportion of the population. Secondly, biopsy is limited by sampling and observer dependent variability which can lead to misclassification of disease severity. Non-invasive biomarkers are therefore needed to replace liver biopsy in the assessment of NAFLD. Our study addresses this unmet need. The LITMUS Imaging Study is a prospectively recruited multi-centre cohort study evaluating magnetic resonance imaging and elastography, and ultrasound elastography against liver histology as the reference standard. Imaging biomarkers and biopsy are acquired within a 100-day window. The study employs standardised processes for imaging data collection and analysis as well as a real time central monitoring and quality control process for all the data submitted for analysis. It is anticipated that the high-quality data generated from this study will underpin changes in clinical practice for the benefit of people with NAFLD. Study Registration: clinicaltrials.gov: NCT05479721

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Mozes, Ferenc E.Univ Oxford, England (author)
  • Akhtar, SalmaUniv Oxford, England (author)
  • Wonders, KristyNewcastle Univ, England; Newcastle Upon Tyne Hosp NHS Fdn Trust, England (author)
  • Cobbold, JeremyUniv Oxford, England (author)
  • Tunnicliffe, Elizabeth M.Univ Oxford, England (author)
  • Allison, MichaelCambridge Univ NHS Fdn Trust, England (author)
  • Godfrey, Edmund M.Cambridge Univ Hosp NHS Fdn Trust, England (author)
  • Aithal, Guruprasad P.Nottingham Univ Hosp NHS Trust, England; Univ Nottingham, England (author)
  • Francis, SusanUniv Nottingham, England (author)
  • Romero-Gomez, ManuelHosp Univ Virgen Rocio, Spain; Univ Valladolid, Spain (author)
  • Castell, JavierHosp Univ Virgen Rocio, Spain (author)
  • Fernandez-Lizaranzu, IsabelHosp Univ Virgen Rocio, Spain (author)
  • Aller, RocioUniv Valladolid, Spain (author)
  • Gonzalez, Rebeca SiguenzaUniv Valladolid, Spain (author)
  • Agustin, SalvadorVall dHebron Barcelona Hosp, Spain (author)
  • Pericas, Juan M.Vall dHebron Barcelona Hosp, Spain (author)
  • Boursier, JeromeCHU Angers, France; Univ Angers, France (author)
  • Aube, ChristopheUniv Angers, France; CHU Angers, France (author)
  • Ratziu, VladSorbonne Univ, France (author)
  • Wagner, MathildeCharles Foix Sorbonne Univ, France (author)
  • Petta, SalvatoreUniv Palermo, Italy (author)
  • Antonucci, MichelaUniv Palermo, Italy (author)
  • Bugianesi, ElisabettaUniv Torino, Italy (author)
  • Faletti, RiccardoUniv Turin, Italy (author)
  • Miele, LucaUniv Cattolica S Cuore, Italy; Fdn Pol Gemelli IRCCS Hosp, Italy (author)
  • Geier, AndreasUniv Wurzburg, Germany (author)
  • Schattenberg, Jorn M.Univ Med Ctr Mainz, Germany (author)
  • Tilman, EmrichJohannes Gutenberg Univ Mainz, Germany (author)
  • Ekstedt, MattiasLinköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Region Östergötland, Mag- tarmmedicinska kliniken(Swepub:liu)matek92 (author)
  • Lundberg, PeterLinköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Region Östergötland, Medicinsk strålningsfysik(Swepub:liu)petlu11 (author)
  • Berzigotti, AnnalisaUniv Bern, Switzerland (author)
  • Huber, Adrian T.Univ Bern, Switzerland (author)
  • Papatheodoridis, GeorgeNatl & Kapodistrian Univ Athens, Greece (author)
  • Yki-Jarvinen, HanneleUniv Helsinki, Finland; Helsinki Univ Hosp, Finland (author)
  • Porthan, KimmoUniv Helsinki, Finland; Helsinki Univ Hosp, Finland (author)
  • Schneider, Moritz JorgAntaros Med AB, Sweden (author)
  • Hockings, PaulAntaros Med AB, Sweden (author)
  • Shumbayawonda, ElizabethPerspectum Ltd, England (author)
  • Banerjee, RajarshiPerspectum Ltd, England (author)
  • Pepin, KayResoundant Inc, MN USA (author)
  • Kalutkiewicz, MikeResoundant Inc, MN USA (author)
  • Ehman, Richard L.Mayo Clin, MN USA (author)
  • Coxson, Harvey O.Boehringer Ingelheim Pharm GmbH & Co KG, Germany (author)
  • Martic, MiljenNovartis AG, Switzerland (author)
  • Yunis, CarlaPfizer Inc, FL USA (author)
  • Tuthill, TheresaPfizer Inc, FL USA (author)
  • Bossuyt, Patrick M.Univ Amsterdam, Netherlands (author)
  • Anstee, Quentin M.Newcastle Univ, England; Newcastle Upon Tyne Hosp NHS Fdn Trust, England (author)
  • Neubauer, StefanUniv Oxford, England (author)
  • Harrison, StephenUniv Oxford, England (author)
  • Univ Oxford, England; John Radcliffe Hosp, EnglandUniv Oxford, England (creator_code:org_t)

Related titles

  • In:Contemporary Clinical Trials: ELSEVIER SCIENCE INC1341551-71441559-2030

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