Pathogen Molecular Pattern Receptor Agonists: Treating Cancer by Mimicking Infection

Aleynick, MarkPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, USA (författare)

mmunotherapies such as checkpoint blockade have achieved durable benefits for patients with advanced stage cancer and have changed treatment paradigms. However, these therapies rely on a patient's own a priori primed tumor-specific T cells, limiting their efficacy to a subset of patients. Because checkpoint blockade is most effective in patients with inflamed or "hot" tumors, a priority in the field is learning how to "turn cold tumors hot." Inflammation is generally initiated by innate immune cells, which receive signals through pattern recognition receptors (PRR)–a diverse family of receptors that sense conserved molecular patterns on pathogens, alarming the immune system of an invading microbe. Their immunostimulatory properties can reprogram the immune suppressive tumor microenvironment and activate antigen-presenting cells to present tumors antigens, driving de novo tumor-specific T-cell responses. These features, among others, make PRR-targeting therapies an attractive strategy in immuno-oncology. Here, we discuss mechanisms of PRR activation, highlighting ongoing clinical trials and recent preclinical advances focused on therapeutically targeting PRRs to treat cancer.

Svensson-Arvelund, Judit,1982-Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, USA(Swepub:liu)judsv82 (författare)
Flowers, Christopher R.Winship Cancer Institute of Emory University, Emory University School of Medicine, Atlanta, Georgia, USA (författare)
Marabelle, AurélienCancer Immunotherapy Program, Gustave Roussy, Villejuif, France (författare)
Brody, Joshua D.1Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York.;4Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, New York. (författare)
Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, USAWinship Cancer Institute of Emory University, Emory University School of Medicine, Atlanta, Georgia, USA (creator_code:org_t)

Ingår i:Clinical Cancer Research: American Association For Cancer Research (AACR)25:21, s. 6283-62941078-04321557-3265

Av författaren/redakt...: Aleynick, Mark; Svensson-Arvelun ...; Flowers, Christo ...; Marabelle, Aurél ...; Brody, Joshua D.

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Medicinska och f ...; och Immunologi inom ...

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.