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  • Boateng, IreneUniv Southampton, England (author)

Using microbiological data to improve the use of antibiotics for respiratory tract infections: A protocol for an individual patient data meta-analysis

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • PUBLIC LIBRARY SCIENCE,2023
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-200041
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-200041URI
  • https://doi.org/10.1371/journal.pone.0294845DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies|National Institute for Health and Care Research (NIHR) School for Primary Care Research [589]
  • BackgroundResistance to antibiotics is rising and threatens future antibiotic effectiveness. 'Antibiotic targeting' ensures patients who may benefit from antibiotics receive them, while being safely withheld from those who may not. Point-of-care tests may assist with antibiotic targeting by allowing primary care clinicians to establish if symptomatic patients have a viral, bacterial, combined, or no infection. However, because organisms can be harmlessly carried, it is important to know if the presence of the virus/bacteria is related to the illness for which the patient is being assessed. One way to do this is to look for associations with more severe/prolonged symptoms and test results. Previous research to answer this question for acute respiratory tract infections has given conflicting results with studies has not having enough participants to provide statistical confidence.AimTo undertake a synthesis of IPD from both randomised controlled trials (RCTs) and observational cohort studies of respiratory tract infections (RTI) in order to investigate the prognostic value of microbiological data in addition to, or instead of, clinical symptoms and signs.MethodsA systematic search of Cochrane Central Register of Controlled Trials, Ovid Medline and Ovid Embase will be carried out for studies of acute respiratory infection in primary care settings. The outcomes of interest are duration of disease, severity of disease, repeated consultation with new/worsening illness and complications requiring hospitalisation. Authors of eligible studies will be contacted to provide anonymised individual participant data. The data will be harmonised and aggregated. Multilevel regression analysis will be conducted to determine key outcome measures for different potential pathogens and whether these offer any additional information on prognosis beyond clinical symptoms and signs.Trial registrationPROSPERO Registration number: CRD42023376769.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Stuart, BethUniv Southampton, England; Queen Mary Univ London, England (author)
  • Becque, TaekoUniv Southampton, England (author)
  • Barrett, BruceUniv Wisconsin, WI USA (author)
  • Bostock, JenniferUniv Southampton, England (author)
  • Bruyndonckx, RobinHasselt Univ, Belgium (author)
  • Carr-Knox, LucyQueen Mary Univ London, England (author)
  • Ciccone, Emily J.Univ North Carolina Chapel Hill, NC USA (author)
  • Coenen, SamuelUniv Antwerp, Belgium; Univ Antwerp, Belgium (author)
  • Ebell, MarkUniv Georgia, GA 30602 USA (author)
  • Gillespie, DavidCardiff Univ, Wales (author)
  • Hayward, GailUniv Oxford, England (author)
  • Hedin, KatarinaLinköpings universitet,Avdelningen för prevention, rehabilitering och nära vård,Medicinska fakulteten,Futurum, Sweden(Swepub:liu)kathe53 (author)
  • Hood, KerenzaCardiff Univ, Wales (author)
  • Lau, Tin Man MandyCardiff Univ, Wales (author)
  • Little, PaulUniv Southampton, England (author)
  • Merenstein, DanGeorgetown Univ, DC 20007 USA (author)
  • Mulogo, EdgarMbarara Univ Sci & Technol, Uganda (author)
  • Ordonez-Mena, JoseUniv Oxford, England (author)
  • Muir, PeterUK Hlth Secur Agcy, England (author)
  • Samuel, KirstyUniv Southampton, England (author)
  • Shaikh, NaderUniv Pittsburgh, PA USA (author)
  • Tonner, SharonUniv Oxford, England (author)
  • van der Velden, Alike W.Univ Med Ctr Utrecht, Netherlands (author)
  • Verheij, TheoUniv Med Ctr Utrecht, Netherlands (author)
  • Wang, KayUniv Southampton, England (author)
  • Hay, Alastair D.Univ Bristol, England (author)
  • Francis, NickUniv Southampton, England (author)
  • Univ Southampton, EnglandUniv Southampton, England; Queen Mary Univ London, England (creator_code:org_t)

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  • In:PLOS ONE: PUBLIC LIBRARY SCIENCE18:111932-6203

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