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Clinical characteri...
Clinical characteristics and novel mutations of omicron subvariant XBB in Tamil Nadu, India - a cohort study
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- Selvavinayagam, Sivaprakasam T. (författare)
- Directorate Publ Hlth & Prevent Med, India
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- Karishma, Sree J. (författare)
- Cent Univ Tamil Nadu, India
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- Hemashree, Kannan (författare)
- Directorate Publ Hlth & Prevent Med, India
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- Yong, Yean K. (författare)
- Xiamen Univ Malaysia, Malaysia
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- Suvaithenamudhan, Suvaiyarasan (författare)
- Cent Univ Tamil Nadu, India; Bishop Heber Coll, India
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- Rajeshkumar, Manivannan (författare)
- Directorate Publ Hlth & Prevent Med, India
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- Aswathy, Bijulal (författare)
- Cent Univ Tamil Nadu, India
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- Kalaivani, Vasudevan (författare)
- Directorate Publ Hlth & Prevent Med, India
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- Priyanka, Jayapal (författare)
- Directorate Publ Hlth & Prevent Med, India
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- Kumaresan, Anandhazhvar (författare)
- Directorate Publ Hlth & Prevent Med, India
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- Kannan, Meganathan (författare)
- Cent Univ Tamil Nadu, India
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- Gopalan, Natarajan (författare)
- Cent Univ Tamil Nadu, India
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- Chandramathi, Samudi (författare)
- Univ Malaya, Malaysia
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- Vignesh, Ramachandran (författare)
- Univ Kuala Lumpur, Malaysia
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- Murugesan, Amudhan (författare)
- Govt Theni Med Coll & Hosp, India
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- Anshad, Abdul R. (författare)
- Cent Univ Tamil Nadu, India
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- Ganesh, Balasubramanian (författare)
- Indian Council Med Res, India
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- Joseph, Narcisse (författare)
- Univ Putra Malaysia, Malaysia
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- Babu, Hemalatha (författare)
- Emory Univ, GA 30329 USA
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- Govindaraj, Sakthivel (författare)
- Emory Univ, GA 30329 USA
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- Larsson, Marie (författare)
- Linköpings universitet,Avdelningen för molekylär medicin och virologi,Medicinska fakulteten
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- Kandasamy, Shree L. (författare)
- Univ Missouri, MO 65211 USA
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- Palani, Sampath (författare)
- Directorate Publ Hlth & Prevent Med, India
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- Singh, Kamalendra (författare)
- Univ Missouri, MO 65211 USA
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- Byrareddy, Siddappa N. (författare)
- Univ Nebraska Med Ctr, NE 68131 USA
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- Velu, Vijayakumar (författare)
- Emory Univ, GA 30329 USA
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- Shankar, Esaki M. (författare)
- Cent Univ Tamil Nadu, India; Cent Univ Tamil Nadu, India
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- Raju, Sivadoss (författare)
- Directorate Publ Hlth & Prevent Med, India; Directorate Publ Hlth & Prevent Med, India
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(creator_code:org_t)
- ELSEVIER, 2023
- 2023
- Engelska.
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Ingår i: The Lancet Regional Health - Southeast Asia. - : ELSEVIER. - 2772-3682. ; 19
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background Despite the continued vaccination efforts, there had been a surge in breakthrough infections, and the emergence of the B.1.1.529 omicron variant of SARS-CoV-2 in India. There is a paucity of information globally on the role of newer XBB variants in community transmission. Here, we investigated the mutational patterns among hospitalised patients infected with the XBB omicron sub-variant, and checked if there was any association between the rise in the number of COVID-19 cases and the observed novel mutations in Tamil Nadu, India. Methods Nasopharyngeal and oropharyngeal swabs, collected from symptomatic and asymptomatic COVID-19 patients were subjected to real-time PCR followed by Next Generation Sequencing (NGS) to rule out the ambiguity of mutations in viruses isolated from the patients (n = 98). Using the phylogenetic association, the mutational patterns were used to corroborate clinico-demographic characteristics and disease severity among the patients. Findings Overall, we identified 43 mutations in the S gene across 98 sequences, of which two were novel mutations (A27S and T747I) that have not been reported previously with XBB sub-variants in the available literature. Additionally, the XBB sequences from our cohort had more mutations than omicron B.1.1.529. The phylogenetic analysis comprising six major branches clearly showed convergent evolution of XBB. Our data suggests that age, and underlying conditions (e.g., diabetes, hypertension, and cardiovascular disease) or secondary complications confers increased susceptibility to infection rather than vaccination status or prior exposure. Many vaccinated individuals showed evidence of a breakthrough infection, with XBB.3 being the predominant variant identified in the study population. Interpretation Our study indicates that the XBB variant is highly evasive from available vaccines and may be more transmissible, and potentially could emerge as the 'next' predominant variant, which likely could overwhelm the existing variants of SARS-CoV-2 omicron variants.Funding National Health Mission (India), SIDA SARC, VINNMER (Sweden), ORIP/NIH (USA).Copyright (c) 2023 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Nyckelord
- COVID-19; Omicron; XBB variants; Severity; Phylogeny; South India
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Selvavinayagam, ...
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Karishma, Sree J ...
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Hemashree, Kanna ...
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Yong, Yean K.
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Suvaithenamudhan ...
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Rajeshkumar, Man ...
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visa fler...
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Aswathy, Bijulal
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Kalaivani, Vasud ...
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Priyanka, Jayapa ...
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Kumaresan, Anand ...
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Kannan, Meganath ...
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Gopalan, Nataraj ...
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Chandramathi, Sa ...
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Vignesh, Ramacha ...
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Murugesan, Amudh ...
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Anshad, Abdul R.
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Ganesh, Balasubr ...
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Joseph, Narcisse
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Babu, Hemalatha
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Govindaraj, Sakt ...
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Larsson, Marie
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Kandasamy, Shree ...
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Palani, Sampath
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Singh, Kamalendr ...
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Byrareddy, Sidda ...
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Velu, Vijayakuma ...
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Shankar, Esaki M ...
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Raju, Sivadoss
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