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Sökning: WFRF:(Lockmer Sandra) > Minimal residual di...

  • Nahi, HarethLinköpings universitet,Institutionen för biomedicinska och kliniska vetenskaper,Medicinska fakulteten,Region Östergötland, Hematologiska kliniken US,Karolinska Inst, Sweden (författare)

Minimal residual disease status is the prognostic determinant following high-dose treatment for patients with multiple myeloma

  • Artikel/kapitelEngelska2023

Förlag, utgivningsår, omfång ...

  • WILEY,2023
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:liu-200753
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-200753URI
  • https://doi.org/10.1002/cam4.6640DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:154092187URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agencies|We would like to extend our gratitude to all patients and their families who participated in this study. Their willingness to contribute has been crucial for the continuation of our research. We would also like to acknowledge the invaluable work of our col
  • Background: The presence of minimal residual disease (MRD+) following autologous stem cell transplantation (ASCT) in multiple myeloma represents a poor prognostic factor for progression-free survival (PFS) and overall survival (OS).Methods: At our department, we recommend lenalidomide maintenance for patients who are MRD+ after ASCT, while MRD-negative (MRD-) patients, after information about the national guidelines, were not advised to follow this regimen.Results: Out of the total 228 patients, 175 received ASCT following first-line induction (MRD- 92 (53%), MRD+ 83 (47%), at 2 months post-ASCT), while 53 underwent ASCT after second-line treatment (MRD- 27 (51%), MRD+ 26 (49%), at the same time point). Comparatively, MRD- patients who did not receive maintenance demonstrated better OS than MRD+ patients who received upfront ASCT and maintenance treatment (96% vs. 86%, p = 0.030, at 3 years). However, nonsignificant difference was found in PFS (76% vs. 62%, at 3 years). Furthermore, second-line ASCT, MRD- non-maintained patients exhibited significantly better PFS than MRD+ (71% vs. 27%, p > 0.001, at 3 years). However, OS was better but nonsignificant (96% vs. 76%, at 3 years). Fluorescence in situ hybridization (FISH) analysis was performed on 141 out of the 228 patients. Of these, 85 (60%) patients were deemed standard risk (SR), and 56 (40%) were classified as high risk (HR). In the SR cohort, MRD- patients exhibited better PFS and OS than MRD+ patients (71% vs. 59% and 100% vs. 85%, respectively). In the HR cohort, the MRD- patients showed superior PFS but similar OS compared to MRD+ patients (66% vs. 42% and 81% vs. 80%, respectively).Conclusions: Our results indicate that being MRD- is a more crucial prognostic factor for the 3-year PFS and OS than the presence of high-risk cytogenetic markers or undergoing maintenance treatment. The latter appears insufficient, particularly for MRD+ patients following ASCT in the second-line setting, suggesting that these patients may require a more intensive treatment approach.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Afram, GabrielKarolinska Inst, Sweden (författare)
  • Uttervall, KatarinaKarolinska Institutet (författare)
  • Lockmer, SandraKarolinska Inst, Sweden (författare)
  • Tätting, Love,1988-Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Hematologiska kliniken US(Swepub:liu)lovta16 (författare)
  • Gahrton, GostaKarolinska Inst, Sweden (författare)
  • Kashif, MuhammadKarolinska Inst, Sweden; Karolinska Inst, Sweden (författare)
  • Alici, EvrenKarolinska Inst, Sweden (författare)
  • Stromberg, OlgaDept Med, Sweden (författare)
  • Klimkowska, MonikaKarolinska Institutet (författare)
  • Lund, JohanKarolinska Inst, Sweden (författare)
  • Linköpings universitetInstitutionen för biomedicinska och kliniska vetenskaper (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Cancer Medicine: WILEY12:22, s. 20736-207442045-7634

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