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Functional SARS-CoV...
Functional SARS-CoV-2 cross-reactive CD4+ T cells established in early childhood decline with age
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- Humbert, Marion (author)
- Karolinska Institutet
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- Olofsson, Anna (author)
- Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, Sweden
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- Wullimann, David (author)
- Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Huddinge, Sweden
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- Niessl, Julia (author)
- Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Sweden
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- Hodcroft, Emma B. (author)
- University of Bern, Switzerland; Swiss Institute of Bioinformatics, Sweitzerland
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- Cai, Curtis (author)
- Karolinska Institutet
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- Gao, Yu (author)
- Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Sweden
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- Sohlberg, Ebba (author)
- Karolinska Institutet
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- Dyrdak, Robert (author)
- Karolinska Institutet
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- Mikaeloff, Flora (author)
- Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, Sweden
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- Neogi, Ujjwal (author)
- Karolinska Institutet
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- Albert, Jan (author)
- Karolinska Institutet
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- Malmberg, Karl-Johan (author)
- Karolinska Institutet
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- Lund-Johansen, Fridtjof (author)
- Oslo University Hospital, Norway; University of Oslo, Norway
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- Aleman, Soo (author)
- Karolinska Institutet
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- Björkhem-Bergman, Linda (author)
- Karolinska Institutet
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- Jenmalm, Maria, Professor, 1971- (author)
- Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten
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- Ljunggren, Hans-Gustaf (author)
- Karolinska Institutet
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- Buggert, Marcus (author)
- Karolinska Institutet
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- Karlsson, Annika C. (author)
- Karolinska Institutet, Sweden
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(creator_code:org_t)
- 2023-03-14
- 2023
- English.
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In: Proceedings of the National Academy of Sciences of the United States of America. - : National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 120:12
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Pre-existing SARS-CoV-2-reactive T cells have been identified in SARS-CoV-2-unexposed individuals, potentially modulating COVID-19 and vaccination outcomes. Here, we provide evidence that functional cross-reactive memory CD4+ T cell immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is established in early childhood, mirroring early seroconversion with seasonal human coronavirus OC43. Humoral and cellular immune responses against OC43 and SARS-CoV-2 were assessed in SARS-CoV-2-unexposed children (paired samples at age two and six) and adults (age 26 to 83). Pre-existing SARS-CoV-2-reactive CD4+ T cell responses targeting spike, nucleocapsid, and membrane were closely linked to the frequency of OC43-specific memory CD4+ T cells in childhood. The functional quality of the cross-reactive memory CD4+ T cell responses targeting SARS-CoV-2 spike, but not nucleocapsid, paralleled OC43-specific T cell responses. OC43-specific antibodies were prevalent already at age two. However, they did not increase further with age, contrasting with the antibody magnitudes against HKU1 (β-coronavirus), 229E and NL63 (α-coronaviruses), rhinovirus, Epstein–Barr virus (EBV), and influenza virus, which increased after age two. The quality of the memory CD4+ T cell responses peaked at age six and subsequently declined with age, with diminished expression of interferon (IFN)-γ, interleukin (IL)-2, tumor necrosis factor (TNF), and CD38 in late adulthood. Age-dependent qualitative differences in the pre-existing SARS-CoV-2-reactive T cell responses may reflect the ability of the host to control coronavirus infections and respond to vaccination. Copyright © 2023 the Author(s).
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- ADP ribosyl cyclase/cyclic ADP ribose hydrolase 1; gamma interferon; interleukin 2; tumor necrosis factor; adult; adulthood; aged; Article; CD4+ T lymphocyte; cellular immunity; child; childhood; comorbidity; controlled study; coronavirus disease 2019; cross reaction; female; human; humoral immunity; major clinical study; male; memory T lymphocyte; nonhuman; protein expression; seroconversion; Severe acute respiratory syndrome coronavirus 2; virus nucleocapsid; virus spike
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Humbert, Marion
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Olofsson, Anna
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Wullimann, David
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Niessl, Julia
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Hodcroft, Emma B ...
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Cai, Curtis
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show more...
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Gao, Yu
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Sohlberg, Ebba
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Dyrdak, Robert
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Mikaeloff, Flora
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Neogi, Ujjwal
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Albert, Jan
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Malmberg, Karl-J ...
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Lund-Johansen, F ...
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Aleman, Soo
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Björkhem-Bergman ...
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Jenmalm, Maria, ...
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Ljunggren, Hans- ...
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Buggert, Marcus
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Karlsson, Annika ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
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Proceedings of t ...
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Linköping University
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Karolinska Institutet