Sökning: WFRF:(Kim Jong Yeob) >
Pharmacological and...
Pharmacological and non-pharmacological interventions for irritability in autism spectrum disorder: a systematic review and meta-analysis with the GRADE assessment
-
- Choi, Hangnyoung (författare)
- Yonsei Univ, South Korea
-
- Kim, Jae Han (författare)
- Yonsei Univ, South Korea
-
- Yang, Hee Sang (författare)
- Yonsei Univ, South Korea
-
visa fler...
-
- Kim, Jong Yeob (författare)
- Yonsei Univ, South Korea; Sungkyunkwan Univ, South Korea
-
- Cortese, Samuele (författare)
- Univ Southampton, England; Solent NHS Trust, England; NYU, NY USA; Univ Bari Aldo Moro, Italy
-
- Smith, Lee (författare)
- Anglia Ruskin Univ, England
-
- Koyanagi, Ai (författare)
- Parc Sanitari St Joan Deu, Spain
-
- Dragioti, Elena (författare)
- Linköpings universitet,Avdelningen för prevention, rehabilitering och nära vård,Medicinska fakulteten,Region Östergötland, Smärt och rehabiliteringscentrum,Univ Ioannina, Greece
-
- Radua, Joaquim (författare)
- Univ Barcelona, Spain
-
- Fusar-Poli, Paolo (författare)
- Kings Coll London, England; Univ Pavia, Italy; South London & Maudsley NHS Fdn Trust, England; Ludwig Maximilian Univ Munich, Germany
-
- Shin, Jae Il (författare)
- Yonsei Univ, South Korea; Yonsei Univ Hlth Syst, South Korea; Yonsei Univ, South Korea
-
- Cheon, Keun-Ah (författare)
- Yonsei Univ, South Korea
-
- Solmi, Marco (författare)
- Univ Ottawa, Canada; Charite, Germany
-
visa färre...
-
(creator_code:org_t)
- BMC, 2024
- 2024
- Engelska.
-
Ingår i: Molecular Autism. - : BMC. - 2040-2392. ; 15:1
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- BackgroundNumerous interventions for irritability in autism spectrum disorder (ASD) have been investigated. We aimed to appraise the magnitude of pharmacological and non-pharmacological interventions for irritability in ASD without any restrictions in terms of eligible interventions.MethodsWe systematically searched PubMed/MEDLINE, Scopus, and Web of Science until April 15, 2023. We included randomized controlled trials (RCTs) with a parallel design that examined the efficacy of interventions for the treatment of irritability in patients of any age with ASD without any restrictions in terms of eligible interventions. We performed a random-effects meta-analysis by pooling effect sizes as Hedges' g. We classified assessed interventions as follows: pharmacological monotherapy, risperidone plus adjuvant therapy versus risperidone monotherapy, non-pharmacological intervention, and dietary intervention. We utilized the Cochrane tool to evaluate the risk of bias in each study and the GRADE approach to assess the certainty of evidence for each meta-analyzed intervention.ResultsOut of 5640 references, we identified 60 eligible articles with 45 different kinds of interventions, including 3531 participants, of which 80.9% were males (mean age [SD] = 8.79 [3.85]). For pharmacological monotherapy, risperidone (Hedges' g - 0.857, 95% CI - 1.263 to - 0.451, certainty of evidence: high) and aripiprazole (Hedges' g - 0.559, 95% CI - 0.767 to - 0.351, certainty of evidence: high) outperformed placebo. Among the non-pharmacological interventions, parent training (Hedges' g - 0.893, 95% CI - 1.184 to - 0.602, certainty of evidence: moderate) showed a significant result. None of the meta-analyzed interventions yielded significant effects among risperidone + adjuvant therapy and dietary supplementation. However, several novel molecules in augmentation to risperidone outperformed risperidone monotherapy, yet from one RCT each.LimitationsFirst, various tools have been utilized to measure the irritability in ASD, which may contribute to the heterogeneity of the outcomes. Second, meta-analyses for each intervention included only a small number of studies and participants.ConclusionsOnly risperidone, aripiprazole among pharmacological interventions, and parent training among non-pharmacological interventions can be recommended for irritability in ASD. As an augmentation to risperidone, several novel treatments show promising effects, but further RCTs are needed to replicate findings.Trial registration PROSPERO, CRD42021243965.ConclusionsOnly risperidone, aripiprazole among pharmacological interventions, and parent training among non-pharmacological interventions can be recommended for irritability in ASD. As an augmentation to risperidone, several novel treatments show promising effects, but further RCTs are needed to replicate findings.Trial registration PROSPERO, CRD42021243965.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Nyckelord
- Autism spectrum disorder; Systematic review; Meta-analysis; Irritability; Randomized controlled trial
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Choi, Hangnyoung
-
Kim, Jae Han
-
Yang, Hee Sang
-
Kim, Jong Yeob
-
Cortese, Samuele
-
Smith, Lee
-
visa fler...
-
Koyanagi, Ai
-
Dragioti, Elena
-
Radua, Joaquim
-
Fusar-Poli, Paol ...
-
Shin, Jae Il
-
Cheon, Keun-Ah
-
Solmi, Marco
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Psykiatri
- Artiklar i publikationen
-
Molecular Autism
- Av lärosätet
-
Linköpings universitet