Sökning: WFRF:(Anstee David) >
Serum ferritin leve...
Serum ferritin levels can predict long-term outcomes in patients with metabolic dysfunction-associated steatotic liver disease
-
- Armandi, Angelo (författare)
- Univ Turin, Italy; Univ Med Ctr, Germany
-
- Sanavia, Tiziana (författare)
- Univ Turin, Italy
-
- Younes, Ramy (författare)
- Boehringer Ingelheim Int GmbH, Germany
-
visa fler...
-
- Caviglia, Gian Paolo (författare)
- Univ Turin, Italy
-
- Rosso, Chiara (författare)
- Univ Turin, Italy
-
- Govaere, Olivier (författare)
- Newcastle Univ, England
-
- Liguori, Antonio (författare)
- Fdn Policlin Univ A Gemelli IRCCS, Italy; Fdn Policlin Univ A Gemelli IRCCS, Italy; Univ Cattolica Sacro Cuore, Italy
-
- Francione, Paolo (författare)
- Fdn IRCCS Ca Granda Osped Maggiore Policlin, Italy
-
- Gallego-Duran, Rocio (författare)
- Virgen Rocio Univ Hosp, Spain
-
- Ampuero, Javier (författare)
- Virgen Rocio Univ Hosp, Spain
-
- Pennisi, Grazia (författare)
- Univ Palermo, Italy
-
- Aller, Rocio (författare)
- Hosp Clin Valladolid, Spain
-
- Tiniakos, Dina (författare)
- Newcastle Univ, England; Natl & Kapodistrian Univ Athens, Greece
-
- Burt, Alastair (författare)
- Newcastle Univ, England
-
- David, Ezio (författare)
- Univ Turin, Italy
-
- Vecchio, Fabio (författare)
- Dipartimento Univ Med & Chirurg Traslazionale, Italy
-
- Maggioni, Marco (författare)
- Ca Granda IRCCS Fdn, Italy
-
- Cabibi, Daniela (författare)
- Univ Palermo, Italy
-
- Mcleod, Duncan (författare)
- Westmead Hosp, Australia
-
- Pareja, Maria Jesus (författare)
- Hosp Univ Valme, Spain
-
- Zaki, Marco Y. W. (författare)
- Newcastle Univ, England; Minia Univ, Egypt
-
- Stal, Per (författare)
- Karolinska Institutet
-
- Kechagias, Stergios (författare)
- Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Mag- tarmmedicinska kliniken
-
- Fracanzani, Anna Ludovica (författare)
- Fdn IRCCS Ca Granda Osped Maggiore Policlin, Italy; Univ Milan, Italy
-
- Valenti, Luca (författare)
- Univ Milan, Italy; Fdn IRCCS Ca Granda Osped Maggiore Policlin Milano, Italy
-
- Grieco, Antonio (författare)
- Dipartimento Univ Med & Chirurg Traslazionale, Italy
-
- Miele, Luca (författare)
- Fdn Policlin Univ A Gemelli IRCCS, Italy; Fdn Policlin Univ A Gemelli IRCCS, Italy; Univ Cattolica Sacro Cuore, Italy
-
- Fariselli, Piero (författare)
- Univ Turin, Italy
-
- Eslam, Mohammed (författare)
- Univ Sydney, Australia
-
- Petta, Salvatore (författare)
- Univ Palermo, Italy
-
- Hagstroem, Hannes (författare)
- Karolinska Institutet
-
- George, Jacob (författare)
- Univ Sydney, Australia
-
- Schattenberg, Joern M. (författare)
- Univ Med Ctr, Germany; Saarland Univ, Germany
-
- Romero-Gomez, Manuel (författare)
- Virgen Rocio Univ Hosp, Spain
-
- Anstee, Quentin Mark (författare)
- Newcastle Univ, England; Newcastle Tyne Hosp NHS Fdn Trust, England
-
- Bugianesi, Elisabetta (författare)
- Univ Turin, Italy
-
visa färre...
-
(creator_code:org_t)
- 2024
- 2024
- Engelska.
-
Ingår i: Gut. - : BMJ PUBLISHING GROUP. - 0017-5749 .- 1468-3288.
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- Objective Hyperferritinaemia is associated with liver fibrosis severity in patients with metabolic dysfunction-associated steatotic liver disease (MASLD), but the longitudinal implications have not been thoroughly investigated. We assessed the role of serum ferritin in predicting long-term outcomes or death. Design We evaluated the relationship between baseline serum ferritin and longitudinal events in a multicentre cohort of 1342 patients. Four survival models considering ferritin with confounders or non-invasive scoring systems were applied with repeated five-fold cross-validation schema. Prediction performance was evaluated in terms of Harrell's C-index and its improvement by including ferritin as a covariate. Results Median follow-up time was 96 months. Liver-related events occurred in 7.7%, hepatocellular carcinoma in 1.9%, cardiovascular events in 10.9%, extrahepatic cancers in 8.3% and all-cause mortality in 5.8%. Hyperferritinaemia was associated with a 50% increased risk of liver-related events and 27% of all-cause mortality. A stepwise increase in baseline ferritin thresholds was associated with a statistical increase in C-index, ranging between 0.02 (lasso-penalised Cox regression) and 0.03 (ridge-penalised Cox regression); the risk of developing liver-related events mainly increased from threshold 215.5 mu g/L (median HR=1.71 and C-index=0.71) and the risk of overall mortality from threshold 272 mu g/L (median HR=1.49 and C-index=0.70). The inclusion of serum ferritin thresholds (215.5 mu g/L and 272 mu g/L) in predictive models increased the performance of Fibrosis-4 and Non-Alcoholic Fatty Liver Disease Fibrosis Score in the longitudinal risk assessment of liver-related events (C-indices>0.71) and overall mortality (C-indices>0.65). Conclusions This study supports the potential use of serum ferritin values for predicting the long-term prognosis of patients with MASLD.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Nyckelord
- NONALCOHOLIC STEATOHEPATITIS; FIBROSIS
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
-
Gut
(Sök värdpublikationen i LIBRIS)
Till lärosätets databas
- Av författaren/redakt...
-
Armandi, Angelo
-
Sanavia, Tiziana
-
Younes, Ramy
-
Caviglia, Gian P ...
-
Rosso, Chiara
-
Govaere, Olivier
-
visa fler...
-
Liguori, Antonio
-
Francione, Paolo
-
Gallego-Duran, R ...
-
Ampuero, Javier
-
Pennisi, Grazia
-
Aller, Rocio
-
Tiniakos, Dina
-
Burt, Alastair
-
David, Ezio
-
Vecchio, Fabio
-
Maggioni, Marco
-
Cabibi, Daniela
-
Mcleod, Duncan
-
Pareja, Maria Je ...
-
Zaki, Marco Y. W ...
-
Stal, Per
-
Kechagias, Sterg ...
-
Fracanzani, Anna ...
-
Valenti, Luca
-
Grieco, Antonio
-
Miele, Luca
-
Fariselli, Piero
-
Eslam, Mohammed
-
Petta, Salvatore
-
Hagstroem, Hanne ...
-
George, Jacob
-
Schattenberg, Jo ...
-
Romero-Gomez, Ma ...
-
Anstee, Quentin ...
-
Bugianesi, Elisa ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Gastroenterologi
- Artiklar i publikationen
-
Gut
- Av lärosätet
-
Linköpings universitet
-
Karolinska Institutet