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Serum ferritin leve...
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Armandi, AngeloUniv Turin, Italy; Univ Med Ctr, Germany
(författare)
Serum ferritin levels can predict long-term outcomes in patients with metabolic dysfunction-associated steatotic liver disease
- Artikel/kapitelEngelska2024
Förlag, utgivningsår, omfång ...
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2024
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BMJ PUBLISHING GROUP,2024
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:liu-200974
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-200974URI
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https://doi.org/10.1136/gutjnl-2023-330815DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:154880735URI
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Språk:engelska
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Sammanfattning på:engelska
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Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Funding Agencies|Italian Ministry for Education, University and Research (MIUR) [D15D18000410001]; PNRR M4C2I1.3 Heal Italia project [PE00000019 CUP B73C22001250006]; Ministry of Health [PNRR-MAD- 2022-12375656, RF- 2021-12372399, PRIN-2022 2022L273C9]; Robert W. Storr Bequest [RF- 2021-12374481]; National Health and Medical Research Council of Australia (NHMRC); Cancer Institute, NSW grant [APP1053206, APP2001692, APP1107178, APP1108422, APP1196492]; [2021/ATRG2028]
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Objective Hyperferritinaemia is associated with liver fibrosis severity in patients with metabolic dysfunction-associated steatotic liver disease (MASLD), but the longitudinal implications have not been thoroughly investigated. We assessed the role of serum ferritin in predicting long-term outcomes or death. Design We evaluated the relationship between baseline serum ferritin and longitudinal events in a multicentre cohort of 1342 patients. Four survival models considering ferritin with confounders or non-invasive scoring systems were applied with repeated five-fold cross-validation schema. Prediction performance was evaluated in terms of Harrell's C-index and its improvement by including ferritin as a covariate. Results Median follow-up time was 96 months. Liver-related events occurred in 7.7%, hepatocellular carcinoma in 1.9%, cardiovascular events in 10.9%, extrahepatic cancers in 8.3% and all-cause mortality in 5.8%. Hyperferritinaemia was associated with a 50% increased risk of liver-related events and 27% of all-cause mortality. A stepwise increase in baseline ferritin thresholds was associated with a statistical increase in C-index, ranging between 0.02 (lasso-penalised Cox regression) and 0.03 (ridge-penalised Cox regression); the risk of developing liver-related events mainly increased from threshold 215.5 mu g/L (median HR=1.71 and C-index=0.71) and the risk of overall mortality from threshold 272 mu g/L (median HR=1.49 and C-index=0.70). The inclusion of serum ferritin thresholds (215.5 mu g/L and 272 mu g/L) in predictive models increased the performance of Fibrosis-4 and Non-Alcoholic Fatty Liver Disease Fibrosis Score in the longitudinal risk assessment of liver-related events (C-indices>0.71) and overall mortality (C-indices>0.65). Conclusions This study supports the potential use of serum ferritin values for predicting the long-term prognosis of patients with MASLD.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Sanavia, TizianaUniv Turin, Italy
(författare)
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Younes, RamyBoehringer Ingelheim Int GmbH, Germany
(författare)
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Caviglia, Gian PaoloUniv Turin, Italy
(författare)
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Rosso, ChiaraUniv Turin, Italy
(författare)
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Govaere, OlivierNewcastle Univ, England
(författare)
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Liguori, AntonioFdn Policlin Univ A Gemelli IRCCS, Italy; Fdn Policlin Univ A Gemelli IRCCS, Italy; Univ Cattolica Sacro Cuore, Italy
(författare)
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Francione, PaoloFdn IRCCS Ca Granda Osped Maggiore Policlin, Italy
(författare)
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Gallego-Duran, RocioVirgen Rocio Univ Hosp, Spain
(författare)
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Ampuero, JavierVirgen Rocio Univ Hosp, Spain
(författare)
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Pennisi, GraziaUniv Palermo, Italy
(författare)
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Aller, RocioHosp Clin Valladolid, Spain
(författare)
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Tiniakos, DinaNewcastle Univ, England; Natl & Kapodistrian Univ Athens, Greece
(författare)
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Burt, AlastairNewcastle Univ, England
(författare)
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David, EzioUniv Turin, Italy
(författare)
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Vecchio, FabioDipartimento Univ Med & Chirurg Traslazionale, Italy
(författare)
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Maggioni, MarcoCa Granda IRCCS Fdn, Italy
(författare)
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Cabibi, DanielaUniv Palermo, Italy
(författare)
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Mcleod, DuncanWestmead Hosp, Australia
(författare)
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Pareja, Maria JesusHosp Univ Valme, Spain
(författare)
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Zaki, Marco Y. W.Newcastle Univ, England; Minia Univ, Egypt
(författare)
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Stal, PerKarolinska Institutet
(författare)
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Kechagias, StergiosLinköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Mag- tarmmedicinska kliniken(Swepub:liu)steke00
(författare)
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Fracanzani, Anna LudovicaFdn IRCCS Ca Granda Osped Maggiore Policlin, Italy; Univ Milan, Italy
(författare)
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Valenti, LucaUniv Milan, Italy; Fdn IRCCS Ca Granda Osped Maggiore Policlin Milano, Italy
(författare)
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Grieco, AntonioDipartimento Univ Med & Chirurg Traslazionale, Italy
(författare)
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Miele, LucaFdn Policlin Univ A Gemelli IRCCS, Italy; Fdn Policlin Univ A Gemelli IRCCS, Italy; Univ Cattolica Sacro Cuore, Italy
(författare)
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Fariselli, PieroUniv Turin, Italy
(författare)
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Eslam, MohammedUniv Sydney, Australia
(författare)
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Petta, SalvatoreUniv Palermo, Italy
(författare)
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Hagstroem, HannesKarolinska Institutet
(författare)
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George, JacobUniv Sydney, Australia
(författare)
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Schattenberg, Joern M.Univ Med Ctr, Germany; Saarland Univ, Germany
(författare)
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Romero-Gomez, ManuelVirgen Rocio Univ Hosp, Spain
(författare)
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Anstee, Quentin MarkNewcastle Univ, England; Newcastle Tyne Hosp NHS Fdn Trust, England
(författare)
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Bugianesi, ElisabettaUniv Turin, Italy
(författare)
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Univ Turin, Italy; Univ Med Ctr, GermanyUniv Turin, Italy
(creator_code:org_t)
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Ingår i:Gut: BMJ PUBLISHING GROUP0017-57491468-3288
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Armandi, Angelo
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Sanavia, Tiziana
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Younes, Ramy
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Caviglia, Gian P ...
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Rosso, Chiara
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Govaere, Olivier
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visa fler...
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Liguori, Antonio
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Francione, Paolo
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Gallego-Duran, R ...
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Ampuero, Javier
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Pennisi, Grazia
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Aller, Rocio
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Tiniakos, Dina
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Burt, Alastair
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David, Ezio
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Vecchio, Fabio
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Maggioni, Marco
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Cabibi, Daniela
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Mcleod, Duncan
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Pareja, Maria Je ...
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Zaki, Marco Y. W ...
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Stal, Per
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Kechagias, Sterg ...
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Fracanzani, Anna ...
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Valenti, Luca
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Grieco, Antonio
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Miele, Luca
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Fariselli, Piero
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Eslam, Mohammed
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Petta, Salvatore
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Hagstroem, Hanne ...
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George, Jacob
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Schattenberg, Jo ...
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Romero-Gomez, Ma ...
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Anstee, Quentin ...
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Bugianesi, Elisa ...
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