Serum ferritin levels can predict long-term outcomes in patients with metabolic dysfunction-associated steatotic liver disease

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: WFRF:(YOUNES W) > Serum ferritin leve...

Serum ferritin levels can predict long-term outcomes in patients with metabolic dysfunction-associated steatotic liver disease

Armandi, Angelo (author): Univ Turin, Italy; Univ Med Ctr, Germany

Sanavia, Tiziana (author): Univ Turin, Italy

Younes, Ramy (author): Boehringer Ingelheim Int GmbH, Germany

Caviglia, Gian Paolo (author): Univ Turin, Italy

Rosso, Chiara (author): Univ Turin, Italy

Govaere, Olivier (author): Newcastle Univ, England

Liguori, Antonio (author): Fdn Policlin Univ A Gemelli IRCCS, Italy; Fdn Policlin Univ A Gemelli IRCCS, Italy; Univ Cattolica Sacro Cuore, Italy

Francione, Paolo (author): Fdn IRCCS Ca Granda Osped Maggiore Policlin, Italy

Gallego-Duran, Rocio (author): Virgen Rocio Univ Hosp, Spain

Ampuero, Javier (author): Virgen Rocio Univ Hosp, Spain

Pennisi, Grazia (author): Univ Palermo, Italy

Aller, Rocio (author): Hosp Clin Valladolid, Spain

Tiniakos, Dina (author): Newcastle Univ, England; Natl & Kapodistrian Univ Athens, Greece

Burt, Alastair (author): Newcastle Univ, England

David, Ezio (author): Univ Turin, Italy

Vecchio, Fabio (author): Dipartimento Univ Med & Chirurg Traslazionale, Italy

Maggioni, Marco (author): Ca Granda IRCCS Fdn, Italy

Cabibi, Daniela (author): Univ Palermo, Italy

Mcleod, Duncan (author): Westmead Hosp, Australia

Pareja, Maria Jesus (author): Hosp Univ Valme, Spain

Zaki, Marco Y. W. (author): Newcastle Univ, England; Minia Univ, Egypt

Stal, Per (author): Karolinska Univ Hosp, Sweden; Huddinge Karolinska Inst, Sweden

Kechagias, Stergios (author): Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Mag- tarmmedicinska kliniken

Fracanzani, Anna Ludovica (author): Fdn IRCCS Ca Granda Osped Maggiore Policlin, Italy; Univ Milan, Italy

Valenti, Luca (author): Univ Milan, Italy; Fdn IRCCS Ca Granda Osped Maggiore Policlin Milano, Italy

Grieco, Antonio (author): Dipartimento Univ Med & Chirurg Traslazionale, Italy

Miele, Luca (author): Fdn Policlin Univ A Gemelli IRCCS, Italy; Fdn Policlin Univ A Gemelli IRCCS, Italy; Univ Cattolica Sacro Cuore, Italy

Fariselli, Piero (author): Univ Turin, Italy

Eslam, Mohammed (author): Univ Sydney, Australia

Petta, Salvatore (author): Univ Palermo, Italy

Hagstroem, Hannes (author): Karolinska Univ Hosp, Sweden; Huddinge Karolinska Inst, Sweden

George, Jacob (author): Univ Sydney, Australia

Schattenberg, Joern M. (author): Univ Med Ctr, Germany; Saarland Univ, Germany

Romero-Gomez, Manuel (author): Virgen Rocio Univ Hosp, Spain

Anstee, Quentin Mark (author): Newcastle Univ, England; Newcastle Tyne Hosp NHS Fdn Trust, England

Bugianesi, Elisabetta (author): Univ Turin, Italy

show less...

(creator_code:org_t)

2024
2024
English.
In: Gut. - : BMJ PUBLISHING GROUP. - 0017-5749 .- 1468-3288.

Related links:: https://urn.kb.se/re...; show more...; https://doi.org/10.1...; http://kipublication...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Objective Hyperferritinaemia is associated with liver fibrosis severity in patients with metabolic dysfunction-associated steatotic liver disease (MASLD), but the longitudinal implications have not been thoroughly investigated. We assessed the role of serum ferritin in predicting long-term outcomes or death. Design We evaluated the relationship between baseline serum ferritin and longitudinal events in a multicentre cohort of 1342 patients. Four survival models considering ferritin with confounders or non-invasive scoring systems were applied with repeated five-fold cross-validation schema. Prediction performance was evaluated in terms of Harrell's C-index and its improvement by including ferritin as a covariate. Results Median follow-up time was 96 months. Liver-related events occurred in 7.7%, hepatocellular carcinoma in 1.9%, cardiovascular events in 10.9%, extrahepatic cancers in 8.3% and all-cause mortality in 5.8%. Hyperferritinaemia was associated with a 50% increased risk of liver-related events and 27% of all-cause mortality. A stepwise increase in baseline ferritin thresholds was associated with a statistical increase in C-index, ranging between 0.02 (lasso-penalised Cox regression) and 0.03 (ridge-penalised Cox regression); the risk of developing liver-related events mainly increased from threshold 215.5 mu g/L (median HR=1.71 and C-index=0.71) and the risk of overall mortality from threshold 272 mu g/L (median HR=1.49 and C-index=0.70). The inclusion of serum ferritin thresholds (215.5 mu g/L and 272 mu g/L) in predictive models increased the performance of Fibrosis-4 and Non-Alcoholic Fatty Liver Disease Fibrosis Score in the longitudinal risk assessment of liver-related events (C-indices>0.71) and overall mortality (C-indices>0.65). Conclusions This study supports the potential use of serum ferritin values for predicting the long-term prognosis of patients with MASLD.

Find in a library

Gut (Search for host publication in LIBRIS)

To the university's database

Find more in SwePub

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Gastroenterology ...

Articles in the publication: Gut

By the university: Linköping University; Karolinska Institutet

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se

Serum ferritin levels can predict long-term outcomes in patients with metabolic dysfunction-associated steatotic liver disease

Subject headings

Keyword

Publication and Content Type

Find in a library

To the university's database

Find more in SwePub

Search outside SwePub