Exercise systolic blood pressure response during cycle ergometry is associated with future hypertension in normotensive individuals

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Carlén, AnnaLinköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Fysiologiska kliniken US (författare)

Exercise systolic blood pressure response during cycle ergometry is associated with future hypertension in normotensive individuals

Artikel/kapitelEngelska2024

Förlag, utgivningsår, omfång ...

2024
OXFORD UNIV PRESS,2024
printrdacarrier

Nummerbeteckningar

LIBRIS-ID:oai:DiVA.org:liu-200975
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-200975URI
https://doi.org/10.1093/eurjpc/zwae012DOI

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Språk:engelska
Sammanfattning på:engelska

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Ämneskategori:art swepub-publicationtype

Anmärkningar

Funding Agencies|Strategic research network CircM, Linkoping University, Sweden; Research Foundation Flanders, Belgium [1225021N]; Research Council KU Leuven [C24M/21/025]
Aims We aimed to investigate the association between the exercise systolic blood pressure (SBP) response and future hypertension (HTN) in normotensive individuals referred for cycle ergometry, with special regard to reference exercise SBP values and exercise capacity.Methods and results In this longitudinal cohort study, data from 14 428 exercise tests were cross-linked with Swedish national registries on diagnoses and medications. We excluded individuals with a baseline diagnosis of cardiovascular disease or HTN. The peak exercise SBP (SBPpeak) was recorded and compared with the upper limit of normal (ULN) derived from SBP(pea)k reference equations incorporating age, sex, resting SBP, and exercise capacity. To evaluate the impact of exercise capacity, three SBP to work rate slopes (SBP/W-slopes) were calculated, relative to either supine or seated SBP at rest or to the first exercise SBP. Adjusted hazard ratios [HRadjusted (95% confidence interval, CI)] for incident HTN during follow-up, in relation to SBP response metrics, were calculated. We included 3895 normotensive individuals (49 +/- 14 years, 45% females) with maximal cycle ergometer tests. During follow-up (median 7.5 years), 22% developed HTN. Higher SBP(peak )and SBPpeak > ULN were associated with incident HTN [HRadjusted 1.19 (1.14-1.23) per 10 mmHg, and 1.95 (1.54-2.47), respectively]. All three SBP/W-slopes were positively associated with incident HTN, particularly the SBP/W-slope calculated as supine-to-peak SBP [HRadjusted 1.25 (1.19-1.31) per 1 mmHg/10 W].Conclusion Both SBPpeak > ULN based on reference values and high SBP/W-slopes were associated with incident HTN in normotensive individuals and should be considered in the evaluation of the cycle ergometry SBP response.Lay summary We examined the systolic blood pressure (SBP) response during maximal bicycle exercise testing in individuals without hypertension (HTN) or established cardiovascular disease and found that:center dot When applying reference values for peak SBP during cycling exercise, accounting for age, sex, resting blood pressure (BP), and exercise capacity, exceeding the upper limit of normal was associated with twice as high relative risk of future HTN, compared with having a peak SBP within normal limits.center dot A steep increase in exercise SBP in relation to the increase in work rate was also associated with future HTN but did not always coincide with elevated peak SBP.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
Exercise physiology; Exercise capacity; SBP/Watt slope; Epidemiology; Reference values; Cardiovascular disease

Biuppslag (personer, institutioner, konferenser, titlar ...)

Lindow, ThomasReg Kronoberg, Sweden; Lund Univ, Sweden (författare)
Cauwenberghs, NicholasUniv Leuven, Belgium (författare)
Elmberg, ViktorBlekinge Hosp, Sweden; Lund Univ, Sweden (författare)
Brudin, LarsKalmar Cty Hosp, Sweden (författare)
Ekstrom, MagnusLund Univ, Sweden (författare)
Hedman, KristoferLinköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Fysiologiska kliniken US(Swepub:liu)krihe93 (författare)
Linköpings universitetAvdelningen för diagnostik och specialistmedicin (creator_code:org_t)

Sammanhörande titlar

Ingår i:European Journal of Preventive Cardiology: OXFORD UNIV PRESS2047-48732047-4881

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Av författaren/redakt...: Carlén, Anna; Lindow, Thomas; Cauwenberghs, Ni ...; Elmberg, Viktor; Brudin, Lars; Ekstrom, Magnus; visa fler...; Hedman, Kristofe ...; visa färre...

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