Multicancer screening test based on the detection of circulating non haematological proliferating atypical cells

Funding Agencies|Amici di Matteo" charity
Background the problem in early diagnosis of sporadic cancer is understanding the individual's risk to develop disease. In response to this need, global scientific research is focusing on developing predictive models based on non-invasive screening tests. A tentative solution to the problem may be a cancer screening blood-based test able to discover those cell requirements triggering subclinical and clinical onset latency, at the stage when the cell disorder, i.e. atypical epithelial hyperplasia, is still in a subclinical stage of proliferative dysregulation. Methods a well-established procedure to identify proliferating circulating tumor cells was deployed to measure the cell proliferation of circulating non-haematological cells which may suggest tumor pathology. Moreover, the data collected were processed by a supervised machine learning model to make the prediction. Results the developed test combining circulating non-haematological cell proliferation data and artificial intelligence shows 98.8% of accuracy, 100% sensitivity, and 95% specificity. Conclusion this proof of concept study demonstrates that integration of innovative non invasive methods and predictive-models can be decisive in assessing the health status of an individual, and achieve cutting-edge results in cancer prevention and management.

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
Cancer prevention; Liquid biopsy; Multicancer diagnosis; Non heamatological proliferating cells; Predictive model; Supervised machine learning; Neural network algorithm

Coluccio, Maria LauraMagna Graecia Univ Catanzaro, Italy (författare)
Grillo, FabianaUniv Leicester, England (författare)
Ferrazzo, TeresaMagna Graecia Univ Catanzaro, Italy (författare)
Garo, Nastassia C.Magna Graecia Univ Catanzaro, Italy (författare)
Donato, GiuseppeMagna Graecia Univ Catanzaro, Italy (författare)
Lavecchia, AnnamariaPugliese Ciaccio Hosp, Italy (författare)
Fulciniti, FrancoUnilabs Pathol, Switzerland (författare)
Sapino, AnnaCandiolo Canc Inst, Italy (författare)
Cascardi, ElianoCandiolo Canc Inst, Italy (författare)
Pellegrini, AntonellaSoc Italiana Citol SICi, Italy (författare)
Foxi, PrassedeUSL Toscana Ctr, Italy (författare)
Furlanello, CesareLIGHT Ctr, Italy (författare)
Negri, GiovanniCent Hosp Bolzano, Italy (författare)
Fadda, GuidoGaetano Barresi Univ, Italy (författare)
Capitanio, ArrigoLinköpings universitet,Avdelningen för neurobiologi,Medicinska fakulteten,Region Östergötland, Klinisk patologi(Swepub:liu)arrca35 (författare)
Pullano, SalvatoreMagna Graecia Univ Catanzaro, Italy (författare)
Garo, Virginia M.Magna Graecia Univ Catanzaro, Italy (författare)
Ferrazzo, FrancescaMagna Graecia Univ Catanzaro, Italy (författare)
Lowe, AlariceStanford Univ Hosp, CA USA (författare)
Torsello, AngelaUOC Oncol, Italy (författare)
Candeloro, PatrizioMagna Graecia Univ Catanzaro, Italy (författare)
Gentile, FrancescoMagna Graecia Univ Catanzaro, Italy (författare)
Magna Graecia Univ Catanzaro, ItalyUniv Leicester, England (creator_code:org_t)

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