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Sökning: WFRF:(Wu Jieying) > Mitochondria-target...

  • Wang, HuiAnhui Univ, Peoples R China (författare)

Mitochondria-targeted iridium (III) complexes as two-photon fluorogenic probes of cysteine/homocysteine

  • Artikel/kapitelEngelska2018

Förlag, utgivningsår, omfång ...

  • ELSEVIER SCIENCE SA,2018
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:liu-201378
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-201378URI
  • https://doi.org/10.1016/j.snb.2017.08.074DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agencies|National Natural Science Foundation of China [51372003, 51432001, 51672002, 21602003, 51472002, 21501001]; Ministry of Education Funded Projects Focus on returned overseas scholar; Higher Education Revitalization Plan Talent Project; Swedish Government Strategic Research Area in Materials Science on Functional Materials at Linkoping University [2009-00971]
  • Fluorescent imaging of cysteine (Cys) and homocysteine (Hcy) is crucial to understand sulphur metabolism in living cells. Whereas two-photon active cyclometalated Ir(III) complex for detecting Cys/Hcy has been rarely reported. Herein, two novel cyclometalated iridium (III) complexes Ir1-1r2 with different electron-donor were designed, synthesized and fully characterized as well as confirmed by single-crystal X-ray diffraction analysis, which could selectively react with Cys/Hcy, accompanying with an obvious one- and two-photon fluorescence enhancement in vitro. The mechanism for sensing Cys/Hcy was further analyzed in detail by mass spectra and time-dependent density functional theory calculations. It was found that Ir2, bearing ester group, exhibited higher performance on the selective detection of Cys and Hcy compared to In. Notably, the two-photon action cross-section value in the near-infrared region (similar to 800 nm) of Ir2 is significantly enhanced upon the addition of Cys/Hcy. Further application to cellular imaging indicated that Ir2 is membrane permeable and capable of monitoring the changes of intracellular mitochondrial Cys/Hcy. These results support that such two-photon active complexes might provide a promising platform for the detection of mitochondrial Cys/Hcy in living biological systems. (C) 2017 Published by Elsevier B.V.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Hu, LeiAnhui Univ, Peoples R China (författare)
  • Du, WeiAnhui Univ, Peoples R China (författare)
  • Tian, XiaoheAnhui Univ, Peoples R China (författare)
  • Hu, ZhangjunLinköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska fakulteten(Swepub:liu)zhahu14 (författare)
  • Zhang, QiongAnhui Univ, Peoples R China (författare)
  • Zhou, HongpingAnhui Univ, Peoples R China (författare)
  • Wu, JieyingAnhui Univ, Peoples R China (författare)
  • Uvdal, KajsaLinköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska fakulteten(Swepub:liu)kajuv09 (författare)
  • Tian, YupengAnhui Univ, Peoples R China; Nanjing Univ, Peoples R China (författare)
  • Anhui Univ, Peoples R ChinaMolekylär ytfysik och nanovetenskap (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Sensors and actuators. B, Chemical: ELSEVIER SCIENCE SA255, s. 408-4150925-40051873-3077

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