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Mitochondria-target...
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Wang, HuiAnhui Univ, Peoples R China
(författare)
Mitochondria-targeted iridium (III) complexes as two-photon fluorogenic probes of cysteine/homocysteine
- Artikel/kapitelEngelska2018
Förlag, utgivningsår, omfång ...
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ELSEVIER SCIENCE SA,2018
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:liu-201378
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-201378URI
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https://doi.org/10.1016/j.snb.2017.08.074DOI
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Språk:engelska
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Sammanfattning på:engelska
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Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Funding Agencies|National Natural Science Foundation of China [51372003, 51432001, 51672002, 21602003, 51472002, 21501001]; Ministry of Education Funded Projects Focus on returned overseas scholar; Higher Education Revitalization Plan Talent Project; Swedish Government Strategic Research Area in Materials Science on Functional Materials at Linkoping University [2009-00971]
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Fluorescent imaging of cysteine (Cys) and homocysteine (Hcy) is crucial to understand sulphur metabolism in living cells. Whereas two-photon active cyclometalated Ir(III) complex for detecting Cys/Hcy has been rarely reported. Herein, two novel cyclometalated iridium (III) complexes Ir1-1r2 with different electron-donor were designed, synthesized and fully characterized as well as confirmed by single-crystal X-ray diffraction analysis, which could selectively react with Cys/Hcy, accompanying with an obvious one- and two-photon fluorescence enhancement in vitro. The mechanism for sensing Cys/Hcy was further analyzed in detail by mass spectra and time-dependent density functional theory calculations. It was found that Ir2, bearing ester group, exhibited higher performance on the selective detection of Cys and Hcy compared to In. Notably, the two-photon action cross-section value in the near-infrared region (similar to 800 nm) of Ir2 is significantly enhanced upon the addition of Cys/Hcy. Further application to cellular imaging indicated that Ir2 is membrane permeable and capable of monitoring the changes of intracellular mitochondrial Cys/Hcy. These results support that such two-photon active complexes might provide a promising platform for the detection of mitochondrial Cys/Hcy in living biological systems. (C) 2017 Published by Elsevier B.V.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Hu, LeiAnhui Univ, Peoples R China
(författare)
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Du, WeiAnhui Univ, Peoples R China
(författare)
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Tian, XiaoheAnhui Univ, Peoples R China
(författare)
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Hu, ZhangjunLinköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska fakulteten(Swepub:liu)zhahu14
(författare)
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Zhang, QiongAnhui Univ, Peoples R China
(författare)
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Zhou, HongpingAnhui Univ, Peoples R China
(författare)
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Wu, JieyingAnhui Univ, Peoples R China
(författare)
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Uvdal, KajsaLinköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska fakulteten(Swepub:liu)kajuv09
(författare)
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Tian, YupengAnhui Univ, Peoples R China; Nanjing Univ, Peoples R China
(författare)
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Anhui Univ, Peoples R ChinaMolekylär ytfysik och nanovetenskap
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Sensors and actuators. B, Chemical: ELSEVIER SCIENCE SA255, s. 408-4150925-40051873-3077
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Wang, Hui
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Hu, Lei
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Du, Wei
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Tian, Xiaohe
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Hu, Zhangjun
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Zhang, Qiong
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visa fler...
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Zhou, Hongping
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Wu, Jieying
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Uvdal, Kajsa
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Tian, Yupeng
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Sensors and actu ...
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Linköpings universitet