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Automated segmentat...
Automated segmentation of human cervical-supraclavicular adipose tissue in magnetic resonance images
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- Lundström, Elin (author)
- Uppsala universitet,Radiologi
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- Strand, Robin, 1978- (author)
- Uppsala universitet,Avdelningen för visuell information och interaktion,Bildanalys och människa-datorinteraktion
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- Forslund, Anders, 1961- (author)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa
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- Bergsten, Peter (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
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Weghuber, Daniel (author)
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- Ahlström, Håkan, 1953- (author)
- Uppsala universitet,Radiologi,Antaros Medical, BioVenture Hub, Mölndal
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- Kullberg, Joel, 1979- (author)
- Uppsala universitet,Radiologi,Antaros Medical, BioVenture Hub, Mölndal
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(creator_code:org_t)
- 2017-06-08
- 2017
- English.
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In: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 7
- Related links:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://www.nature.c...
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Abstract
Subject headings
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- Human brown adipose tissue (BAT), with a major site in the cervical-supraclavicular depot, is a promising anti-obesity target. This work presents an automated method for segmenting cervical-supraclavicular adipose tissue for enabling time-efficient and objective measurements in large cohort research studies of BAT. Fat fraction (FF) and R2* maps were reconstructed from water-fat magnetic resonance imaging (MRI) of 25 subjects. A multi-atlas approach, based on atlases from nine subjects, was chosen as automated segmentation strategy. A semi-automated reference method was used to validate the automated method in the remaining subjects. Automated segmentations were obtained from a pipeline of preprocessing, affine registration, elastic registration and postprocessing. The automated method was validated with respect to segmentation overlap (Dice similarity coefficient, Dice) and estimations of FF, R2* and segmented volume. Bias in measurement results was also evaluated. Segmentation overlaps of Dice = 0.93 +/- 0.03 (mean +/- standard deviation) and correlation coefficients of r > 0.99 (P < 0.0001) in FF, R2* and volume estimates, between the methods, were observed. Dice and BMI were positively correlated (r = 0.54, P = 0.03) but no other significant bias was obtained (P >= 0.07). The automated method compared well with the reference method and can therefore be suitable for time-efficient and objective measurements in large cohort research studies of BAT.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Keyword
- Computerized Image Processing
- Datoriserad bildbehandling
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Lundström, Elin
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Strand, Robin, 1 ...
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Forslund, Anders ...
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Bergsten, Peter
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Weghuber, Daniel
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Ahlström, Håkan, ...
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show more...
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Kullberg, Joel, ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Radiology Nuclea ...
- Articles in the publication
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Scientific Repor ...
- By the university
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Uppsala University