Search: id:"swepub:oai:DiVA.org:liu-201655" >
Skin perfusion and ...
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Elawa, SherifLinköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Hand- och plastikkirurgiska kliniken US
(author)
Skin perfusion and oxygen saturation after mastectomy and radiation therapy in breast cancer patients
- Article/chapterEnglish2024
Publisher, publication year, extent ...
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2024
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Elsevier,2024
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:liu-201655
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-201655URI
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https://doi.org/10.1016/j.breast.2024.103704DOI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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The pathophysiological mechanism behind complications associated with postmastectomy radiotherapy (PMRT) and subsequent implant-based breast reconstruction are not completely understood. The aim of this study was to examine if there is a relationship between PMRT and microvascular perfusion and saturation in the skin after mastectomy and assess if there is impaired responsiveness to a topically applied vasodilator (Methyl nicotinate - MN). Skin microvascular perfusion and oxygenation >2 years after PMRT were measured using white light diffuse reflectance spectroscopy (DRS) and laser Doppler flowmetry (LDF) in the irradiated chest wall of 31 women with the contralateral breast as a control. In the non-irradiated breast, the perfusion after application of MN (median 0.84, 25th-75th centile 0.59-1.02 % RBC × mm/s) was higher compared to the irradiated chest wall (median 0.51, 25th-75th centile 0.21-0.68 % RBC × mm/s, p < 0.001). The same phenomenon was noted for saturation (median 91 %, 25th-75th centile 89-94 % compared to 89 % 25th-75th centile 77-93 %, p = 0.001). Eight of the women (26%) had a ≥10 % difference in skin oxygenation between the non-irradiated breast and the irradiated chest wall. These results indicate that late microvascular changes caused by radiotherapy of the chest wall significantly affect skin perfusion and oxygenation.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Fredriksson, Ingemar,1980-Linköpings universitet,Avdelningen för medicinsk teknik,Tekniska fakulteten,Perimed AB, Järfälla, Stockholm, Sweden(Swepub:liu)ingfr98
(author)
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Steinvall, Ingrid,1959-Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Hand- och plastikkirurgiska kliniken US(Swepub:liu)ingst90
(author)
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Zötterman, Johan,1975-Linköpings universitet,Medicinska fakulteten,Avdelningen för kirurgi, ortopedi och onkologi,Region Östergötland, Hand- och plastikkirurgiska kliniken US(Swepub:liu)johzo75
(author)
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Farnebo, Simon,1972-Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Hand- och plastikkirurgiska kliniken US(Swepub:liu)simfa69
(author)
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Droog Tesselaar, Erik,1977-Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Medicinsk strålningsfysik(Swepub:liu)eridr03
(author)
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Linköpings universitetAvdelningen för kirurgi, ortopedi och onkologi
(creator_code:org_t)
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In:Breast: Elsevier750960-97761532-3080
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