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Multi-site benchmar...
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Belov, VladimirGeorg August Univ, Germany
(författare)
Multi-site benchmark classification of major depressive disorder using machine learning on cortical and subcortical measures
- Artikel/kapitelEngelska2024
Förlag, utgivningsår, omfång ...
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NATURE PORTFOLIO,2024
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:liu-201855
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-201855URI
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https://doi.org/10.1038/s41598-023-47934-8DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Funding Agencies|NIH [U54 EB020403, R01MH116147, MH117601, R37 MH101495]; ERA-NET PRIOMEDCHILD FP 6 (EU) [11.32050.26]; University Medical Center Gottingen (UMG Startforderung); German Federal Ministry of Education and Research (Bundesministerium fuer Bildung und Forschung) [BMBF: 01 ZX 1507]; Ministerio de Ciencia e Innovacion of the Spanish Government; Instituto de Salud Carlos III through a 'Miguel Servet' research contract [CP16-0020]; National Research Plan (Plan Estatal de I + D + I 2016-2019); European Regional Development Fund (ERDF); Medical Research Council [G 1100629]; National Center for Mental Health (NCMH) - Health Research Wales [HS/14/20]; Johnson & Johnson Innovation; Swedish Medical Research Council [2017-00875, 2013-07434, 2019-01138]; ALF Grants, Region Ostergotland; National Institutes of Health [R01 CA193522, R01 NS073939]; MD Anderson Cancer Support Grant [P30CA016672]; Canadian Institutes for Health Research; Branch Out Neurological Foundation; Alberta Children's Hospital Foundation; Medical Research Council of South Africa; Intramural Research Program at the National Institute of Mental Health, National Institutes of Health (IRP-NIMH-NIH) [ZIA-MH002857]; GGZ Rivierduinen; LUMC; Generalitat de Catalunya [2014 SGR 1573]; Instituto de Salud Carlos III [CPII16/00018, PI14/01151, PI14/01148]; Gratama Foundation, the Netherlands [2012/35]; NIMH [R01 085667]; Dunn Research Foundation; NIHR Maudsley Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London; National Health and Medical Research Council of Australia (NHMRC) [1064643, 1024570]; National Institute of Mental Health [K23MH090421]; Biotechnology Research Center [P41 RR008079]; National Alliance for Research on Schizophrenia and Depression; University of Minnesota Graduate School; Minnesota Medical Foundation; Brain and Behavior Research Foundation; National Health and Medical Research Council [1125504]; Geestkracht program of the Netherlands Organisation for Health Research and Development (Zon-Mw) [10-000-1002]; VU University Medical Center; GGZ inGeest; Arkin; Leiden University Medical Center; University Medical Center Groningen; Australian National Health and Medical Research Council [496682, 1009064]; US National Institute of Child Health and Human Development [RO1HD050735]; A National Institute of Mental Health [R01MH085734, K01MH117442]; American Foundation for Suicide Prevention [PDF-1-064-13]; German Federal State of Mecklenburg-West Pomerania; Siemens Healthineers, Erlangen, Germany; Federal State of Mecklenburg-West Pomerania; EU-JPND Funding for BRIDGET [FKZ:01ED1615]; Italian Ministry of Health [RF-2011-02349921, RF-2018-12367489]; Italian Ministry of Education, University and Research (Miur) [PRIN -201779W93T]; NHG [SIG/15012]; National Healthcare Group, Singapore [SIG/15012]; Ege University Research Fund [17-TIP-039, 15-TIP-002, 13-TIP-054]; Scientific and Technological Research Council of Turkey [109S134, 217S228]; Klingenstein Third Generation Foundation the National Institute of Mental Health [K01MH117442]; Ray and Dagmar Dolby Family Fund; Gottingen University
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Machine learning (ML) techniques have gained popularity in the neuroimaging field due to their potential for classifying neuropsychiatric disorders. However, the diagnostic predictive power of the existing algorithms has been limited by small sample sizes, lack of representativeness, data leakage, and/or overfitting. Here, we overcome these limitations with the largest multi-site sample size to date (N = 5365) to provide a generalizable ML classification benchmark of major depressive disorder (MDD) using shallow linear and non-linear models. Leveraging brain measures from standardized ENIGMA analysis pipelines in FreeSurfer, we were able to classify MDD versus healthy controls (HC) with a balanced accuracy of around 62%. But after harmonizing the data, e.g., using ComBat, the balanced accuracy dropped to approximately 52%. Accuracy results close to random chance levels were also observed in stratified groups according to age of onset, antidepressant use, number of episodes and sex. Future studies incorporating higher dimensional brain imaging/phenotype features, and/or using more advanced machine and deep learning methods may yield more encouraging prospects.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Erwin-Grabner, TracyGeorg August Univ, Germany
(författare)
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Aghajani, MojiVrije Univ Amsterdam, Netherlands; Leiden Univ, Netherlands
(författare)
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Aleman, AndreUniv Groningen, Netherlands
(författare)
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Amod, Alyssa R.Univ Cape Town, South Africa
(författare)
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Basgoze, ZeynepUniv Minnesota, MN 55417 USA
(författare)
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Benedetti, FrancescoIRCCS San Raffaele Sci Inst, Italy
(författare)
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Besteher, BiancaJena Univ Hosp, Germany
(författare)
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Bülow, RobinUniv Med Greifswald, Germany
(författare)
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Ching, Christopher R. K.Univ Southern Calif, CA USA
(författare)
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Connolly, Colm G.Florida State Univ, FL 32306 USA
(författare)
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Cullen, KathrynUniv Minnesota, MN 55417 USA
(författare)
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Davey, Christopher G.Univ Melbourne, Australia
(författare)
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Dima, DanaiCity Univ London, England; Kings Coll London, England
(författare)
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Dols, AnnemiekVrije Univ Amsterdam, Netherlands
(författare)
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Evans, Jennifer W.NIMH, MD 20892 USA
(författare)
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Fu, Cynthia H. Y.Univ East London, England; Kings Coll London, England
(författare)
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Gonul, Ali SaffetEge Univ, Turkiye
(författare)
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Gotlib, Ian H.Stanford Univ, CA 94305 USA
(författare)
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Grabe, Hans J.Univ Med Greifswald, Germany
(författare)
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Groenewold, NynkeUniv Cape Town, South Africa
(författare)
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Hamilton, PaulLinköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV(Swepub:liu)pauha77
(författare)
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Harrison, Ben J.Univ Melbourne, Australia
(författare)
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Ho, Tiffany C.Univ Calif San Francisco, CA 94143 USA
(författare)
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Mwangi, BensonUniv Texas Hlth Sci Ctr Houston, TX 77030 USA
(författare)
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Jaworska, NataliaMcGill Univ, Canada
(författare)
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Jahanshad, NedaUniv Southern Calif, CA USA
(författare)
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Klimes-Dougan, BonnieUniv Minnesota, MN USA
(författare)
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Koopowitz, Sheri-MichelleUniv Cape Town, South Africa
(författare)
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Lancaster, ThomasCardiff Univ, Wales
(författare)
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Li, MengJena Univ Hosp, Germany
(författare)
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Linden, David E. J.Cardiff Univ, Wales; Maastricht Univ, Netherlands
(författare)
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MacMaster, Frank P.Univ Calgary, Canada
(författare)
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Mehler, David M. A.Cardiff Univ, Wales; Rhein Westfal TH Aachen, Germany
(författare)
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Melloni, ElisaIRCCS San Raffaele Sci Inst, Italy
(författare)
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Mueller, Bryon A.Univ Minnesota, MN 55417 USA
(författare)
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Ojha, AmarUniv Pittsburgh, PA USA
(författare)
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Oudega, Mardien L.Vrije Univ Amsterdam, Netherlands
(författare)
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Penninx, Brenda W. J. H.Vrije Univ Amsterdam, Netherlands
(författare)
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Poletti, SaraIRCCS San Raffaele Sci Inst, Italy
(författare)
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Pomarol-Clotet, EdithFIDMAG Germanes Hosp Res Fdn, Spain
(författare)
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Portella, Maria J.Inst Recerca LHosp Santa Creu I St Pau, Spain
(författare)
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Pozzi, ElenaUniv Melbourne, Australia; Orygen, Australia
(författare)
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Reneman, LiesbethUniv Amsterdam, Netherlands
(författare)
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Sacchet, Matthew D.Harvard Med Sch, MA USA
(författare)
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Saemann, Philipp G.Max Planck Inst Psychiat, Germany
(författare)
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Schrantee, AnoukUniv Amsterdam, Netherlands
(författare)
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Sim, KangWest Reg Inst Mental Hlth, Singapore; Natl Univ Singapore, Singapore; Nanyang Technol Univ, Singapore
(författare)
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Soares, Jair C.Univ Texas Hlth Sci Ctr Houston, TX 77030 USA
(författare)
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Stein, Dan J.Univ Cape Town, South Africa
(författare)
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Thomopoulos, Sophia I.Univ Southern Calif, CA USA
(författare)
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Uyar-Demir, AslihanEge Univ, Turkiye
(författare)
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van der Wee, Nic J. A.Leiden Univ, Netherlands
(författare)
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van der Werff, Steven J. A.Leiden Univ, Netherlands
(författare)
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Voelzke, HenryUniv Med Greifswald, Germany
(författare)
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Whittle, SarahUniv Melbourne, Australia; Melbourne Hlth, Australia
(författare)
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Wittfeld, KatharinaGerman Ctr Neurodegenerat Dis DZNE, Germany
(författare)
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Wright, Margaret J.Univ Queensland, Australia
(författare)
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Wu, Mon-JuUniv Texas Hlth Sci Ctr Houston, TX 77030 USA
(författare)
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Yang, Tony T.Univ Calif San Francisco, CA 94143 USA
(författare)
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Zarate, CarlosNIMH, MD 20892 USA
(författare)
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Veltman, Dick J.Vrije Univ Amsterdam, Netherlands
(författare)
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Schmaal, LianneUniv Melbourne, Australia
(författare)
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Thompson, Paul M.Univ Southern Calif, CA USA
(författare)
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Goya-Maldonado, RobertoGeorg August Univ, Germany
(författare)
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Georg August Univ, GermanyVrije Univ Amsterdam, Netherlands; Leiden Univ, Netherlands
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Scientific Reports: NATURE PORTFOLIO14:12045-2322
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Belov, Vladimir
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Erwin-Grabner, T ...
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Aghajani, Moji
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Aleman, Andre
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Amod, Alyssa R.
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Basgoze, Zeynep
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visa fler...
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Benedetti, Franc ...
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Besteher, Bianca
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Bülow, Robin
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Ching, Christoph ...
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Connolly, Colm G ...
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Cullen, Kathryn
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Davey, Christoph ...
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Dima, Danai
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Dols, Annemiek
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Evans, Jennifer ...
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Fu, Cynthia H. Y ...
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Gonul, Ali Saffe ...
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Gotlib, Ian H.
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Grabe, Hans J.
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Groenewold, Nynk ...
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Hamilton, Paul
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Harrison, Ben J.
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Ho, Tiffany C.
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Mwangi, Benson
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Jaworska, Natali ...
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Jahanshad, Neda
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Klimes-Dougan, B ...
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Koopowitz, Sheri ...
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Lancaster, Thoma ...
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Li, Meng
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Linden, David E. ...
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MacMaster, Frank ...
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Mehler, David M. ...
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Melloni, Elisa
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Mueller, Bryon A ...
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Ojha, Amar
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Oudega, Mardien ...
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Penninx, Brenda ...
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Poletti, Sara
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Pomarol-Clotet, ...
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Portella, Maria ...
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Pozzi, Elena
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Reneman, Liesbet ...
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Sacchet, Matthew ...
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Saemann, Philipp ...
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Schrantee, Anouk
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Sim, Kang
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Soares, Jair C.
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Stein, Dan J.
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Thomopoulos, Sop ...
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Uyar-Demir, Asli ...
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van der Wee, Nic ...
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van der Werff, S ...
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Voelzke, Henry
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Whittle, Sarah
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Wittfeld, Kathar ...
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Wright, Margaret ...
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Wu, Mon-Ju
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Yang, Tony T.
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Zarate, Carlos
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Veltman, Dick J.
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Schmaal, Lianne
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Thompson, Paul M ...
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Goya-Maldonado, ...
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