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Obstructive sleep a...
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Missey, FlorianInternational Clinical Research Center, St. Anne’s University Hospital Brno, Czech Republic; Institute de Neurosciences des Systèmes (INS), INSERM, Aix-Marseille Université, France
(författare)
Obstructive sleep apnea improves with non-invasive hypoglossal nerve stimulation using temporal interference
- Artikel/kapitelEngelska2023
Förlag, utgivningsår, omfång ...
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BioMed Central (BMC),2023
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:liu-201887
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-201887URI
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https://doi.org/10.1186/s42234-023-00120-7DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Funding agencies: the European Research Council (ERC) under th eEuropean Union’s Horizon 2020 research and innovation programme (grant agreement No 716867), the European Research Council(834677 “e-NeuroPharma” ERC-2018-ADG), the National Center for Neurological Research, supported by the Czech Ministry of Education, Youth, and Sports (LX22NPO5107), and funding from the Brno city council.
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Background: Peripheral nerve stimulation is used in both clinical and fundamental research for therapy and exploration. At present, non-invasive peripheral nerve stimulation still lacks the penetration depth to reach deep nerve targets and the stimulation focality to offer selectivity. It is therefore rarely employed as the primary selected nerve stimulation method. We have previously demonstrated that a new stimulation technique, temporal interference stimulation, can overcome depth and focality issues.Methods: Here, we implement a novel form of temporal interference, bilateral temporal interference stimulation, for bilateral hypoglossal nerve stimulation in rodents and humans. Pairs of electrodes are placed alongside both hypoglossal nerves to stimulate them synchronously and thus decrease the stimulation amplitude required to activate hypoglossal-nerve-controlled tongue movement.Results: Comparing bilateral temporal interference stimulation with unilateral temporal interference stimulation, we show that it can elicit the same behavioral and electrophysiological responses at a reduced stimulation amplitude. Traditional transcutaneous stimulation evokes no response with equivalent amplitudes of stimulation.Conclusions: During first-in-man studies, temporal interference stimulation was found to be well-tolerated, and to clinically reduce apnea-hypopnea events in a subgroup of female patients with obstructive sleep apnea. These results suggest a high clinical potential for the use of temporal interference in the treatment of obstructive sleep apnea and other diseases as a safe, effective, and patient-friendly approach.Trial registration: The protocol was conducted with the agreement of the International Conference on Harmonisation Good Clinical Practice (ICH GCP), applicable United States Code of Federal Regulations (CFR) and followed the approved BRANY IRB File # 22-02-636-1279.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Silverå Ejneby, Malin,1987-Linköpings universitet,Avdelningen för medicinsk teknik,Tekniska fakulteten(Swepub:liu)malsi14
(författare)
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Ngom, IbrahimaInstitute de Neurosciences des Systèmes (INS), INSERM, Aix-Marseille Université, France
(författare)
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Donahue, MaryLinköpings universitet,Laboratoriet för organisk elektronik,Tekniska fakulteten(Swepub:liu)mardo25
(författare)
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Trajlinek, JanCentral European Institute of Technology, Brno University of Technology, Czech Republic
(författare)
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Acerbo, EmmaInstitute de Neurosciences des Systèmes (INS), INSERM, Aix-Marseille Université, Marseille, France
(författare)
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Botzanowski, BorisInstitute de Neurosciences des Systèmes (INS), INSERM, Aix-Marseille Université, Marseille, France
(författare)
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Cassarà, Antonino M.IT’IS Foundation for Research on Information Technologies in Society, Switzerland
(författare)
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Neufeld, EsraIT’IS Foundation for Research on Information Technologies in Society, Zurich, 8004, Switzerland
(författare)
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Glowacki, Eric D.Central European Institute of Technology, Brno University of Technology, Brno, Czech Republic
(författare)
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Shangold, LeeENT and Allergy Associates, 1500 Route 112, Port Jefferson Station, New York, USA
(författare)
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Hanes, William M.Somnial Inc, USA
(författare)
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Williamson, AdamInternational Clinical Research Center, St. Anne’s University Hospital Brno, Brno, 60200, Czech Republic; Institute de Neurosciences des Systèmes (INS), INSERM, Aix-Marseille Université, Marseille, France; Central European Institute of Technology, Brno University of Technology, Czech Republic
(författare)
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International Clinical Research Center, St. Anne’s University Hospital Brno, Czech Republic; Institute de Neurosciences des Systèmes (INS), INSERM, Aix-Marseille Université, FranceAvdelningen för medicinsk teknik
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Bioelectronic Medicine: BioMed Central (BMC)9:12332-8886
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Missey, Florian
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Silverå Ejneby, ...
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Ngom, Ibrahima
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Donahue, Mary
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Trajlinek, Jan
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Acerbo, Emma
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Botzanowski, Bor ...
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Cassarà, Antonin ...
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Neufeld, Esra
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Glowacki, Eric D ...
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Shangold, Lee
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Hanes, William M ...
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Williamson, Adam
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