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Activin A levels in...
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Jönsson, CeciliaLinköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten
(författare)
Activin A levels in metabolic dysfunction-associated steatotic liver disease associates with fibrosis and the PNPLA3 I148M variant
- Artikel/kapitelEngelska2024
Förlag, utgivningsår, omfång ...
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2024
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TAYLOR & FRANCIS LTD,2024
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Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:liu-202487
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-202487URI
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https://doi.org/10.1080/00365521.2024.2334804DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Funding Agencies|ALF Grants; Region Ostergotland; Swedish Medical Society; Bengt Ihre Foundation; Ruth and Richard Julin Foundation; Wallenberg Centre for Molecular Medicine, Linkoping University
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Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver condition worldwide. There is an urgent need to develop new biomarkers to assess disease severity and to define patients with a progressive phenotype. Activin A is a new promising biomarker with conflicting results about liver fibrosis. In this study we investigate levels of Activin A in patients with biopsy proven MASLD. We assess levels of Activin A in regard to fibrosis stage and genetic variant I148M in the patatin-like phospholipase domain-containing protein 3 (PNPLA3). Methods: Activin A levels were assessed in plasma samples from patients with biopsy-proven MASLD in a cross-sectional study. All patients were clinically evaluated and the PNPLA3 I148M genotype of the cohort was assessed. Findings41 patients were included and 27% of these had advanced fibrosis. In MASLD patients with advanced fibrosis, Activin A levels was higher (p < 0.001) and could classify advanced fibrosis with an AUROC for activin A of 0.836 (p < 0.001). Patients homozygous for PNPLA3 I148M G/G had higher levels of activin A than non-homozygotes (p = 0.027). Conclusions: Circulating activin A levels were associated with advanced fibrosis and could be a potential blood biomarker for identifying advanced fibrosis in MASLD. Patients with the risk genotype PNPLA3 I148M G/G had higher levels of activin A proposing activin A as a contributor of the transition from simple steatosis to a fibrotic phenotype.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Bergram, MartinLinköpings universitet,Avdelningen för prevention, rehabilitering och nära vård,Medicinska fakulteten,Region Östergötland, Vårdcentralen Ekholmen(Swepub:liu)marbe03
(författare)
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Kechagias, StergiosLinköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Mag- tarmmedicinska kliniken(Swepub:liu)steke00
(författare)
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Nasr, PatrikLinköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Mag- tarmmedicinska kliniken,Wallenberg Centre for Molecular Medicine(Swepub:liu)patna19
(författare)
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Ekstedt, MattiasLinköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Mag- tarmmedicinska kliniken(Swepub:liu)matek92
(författare)
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Linköpings universitetAvdelningen för diagnostik och specialistmedicin
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Scandinavian Journal of Gastroenterology: TAYLOR & FRANCIS LTD0036-55211502-7708
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