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Symptoms and signs ...
Symptoms and signs in patients with heart failure: association with 3-month hospitalisation and mortality
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- Ali, Mohammad Rizwan (författare)
- Univ Leicester, England; NIHR Leicester Biomed Res Ctr, England; Univ Leicester, England; Univ Leicester, England
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- Lam, Carolyn S. P. (författare)
- Natl Heart Ctr, Singapore; Natl Univ Singapore, Singapore
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- Strömberg, Anna (författare)
- Linköpings universitet,Avdelningen för omvårdnad och reproduktiv hälsa,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US
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- Hand, Simon P. P. (författare)
- Univ Leicester, England
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- Booth, Sarah (författare)
- Univ Leicester, England
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- Zaccardi, Francesco (författare)
- Univ Leicester, England; Univ Leicester, England
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- Squire, Iain (författare)
- Univ Leicester, England; NIHR Leicester Biomed Res Ctr, England
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- Mccann, Gerry P. (författare)
- Univ Leicester, England; NIHR Leicester Biomed Res Ctr, England
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- Khunti, Kamlesh (författare)
- Univ Leicester, England; Univ Leicester, England
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- Lawson, Claire Alexandra (författare)
- Univ Leicester, England; NIHR Leicester Biomed Res Ctr, England
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(creator_code:org_t)
- BMJ PUBLISHING GROUP, 2024
- 2024
- Engelska.
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Ingår i: Heart. - : BMJ PUBLISHING GROUP. - 1355-6037 .- 1468-201X. ; 110:8, s. 578-585
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Objectives To determine the association between symptoms and signs reported in primary care consultations following a new diagnosis of heart failure (HF), and 3-month hospitalisation and mortality.Design Nested case-control study with density-based sampling.Setting Clinical Practice Research Datalink, linked to hospitalisation and mortality (1998-2020).Participants Database cohort of 86 882 patients with a new HF diagnosis. In two separate analyses for (1) first hospitalisation and (2) death, we compared the 3-month history of symptoms and signs in cases (patients with HF with the event), with their respective controls (patients with HF without the respective event, matched on diagnosis date (+/- 1 month) and follow-up time). Controls could be included more than once and later become a case.Main outcome measures All-cause, HF and non-cardiovascular disease (non-CVD) hospitalisation and mortality.Results During a median follow-up of 3.22 years (IQR: 0.59-8.18), 56 677 (65%) experienced first hospitalisation and 48 146 (55%) died. These cases were matched to 356 714 and 316 810 HF controls, respectively. For HF hospitalisation, the strongest adjusted associations were for symptoms and signs of fluid overload: pulmonary oedema (adjusted OR 3.08; 95% CI 2.52, 3.64), shortness of breath (2.94; 2.77, 3.11) and peripheral oedema (2.16; 2.00, 2.32). Generic symptoms also showed significant associations: depression (1.50; 1.18, 1.82), anxiety (1.35; 1.06, 1.64) and pain (1.19; 1.10, 1.28). Non-CVD hospitalisation had the strongest associations with chest pain (2.93; 2.77, 3.09), fatigue (1.87; 1.73, 2.01), general pain (1.87; 1.81, 1.93) and depression (1.59; 1.44, 1.74).Conclusions In the primary care HF population, routinely recorded cardiac and non-specific symptoms showed differential risk associations with hospitalisation and mortality.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- heart failure; epidemiology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Heart
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Ali, Mohammad Ri ...
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Lam, Carolyn S. ...
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Strömberg, Anna
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Hand, Simon P. P ...
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Booth, Sarah
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Zaccardi, France ...
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Squire, Iain
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Mccann, Gerry P.
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Khunti, Kamlesh
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Lawson, Claire A ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
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Heart
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Linköpings universitet