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  • Lawson, Claire ADepartment of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom; National Institute for Health Research (NIHR) Biomedical Research Centre, University of Leicester, Leicester, United Kingdom; Leicester Real World Evidence Unit, Leicester, United Kingdom; NIHR Applied Research Collaboration-East Midlands, University of Leicester, Leicester, United Kingdom (author)

Patient-Reported Status and Heart Failure Outcomes in Asia by Sex, Ethnicity, and Socioeconomic Status

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • Elsevier,2023
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-202818
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-202818URI
  • https://doi.org/10.1016/j.jacasi.2023.03.015DOI

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  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

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  • Background: In heart failure (HF), symptoms and health-related quality of life (HRQoL) are known to vary among different HF subgroups, but evidence on the association between changing HRQoL and outcomes has not been evaluated.Objectives: The authors sought to investigate the relationship between changing symptoms, signs, and HRQoL and outcomes by sex, ethnicity, and socioeconomic status (SES).Methods: Using the ASIAN-HF (Asian Sudden Cardiac Death in Heart Failure) Registry, we investigated associations between the 6-month change in a "global" symptoms and signs score (GSSS), Kansas City Cardiomyopathy Questionnaire overall score (KCCQ-OS), and visual analogue scale (VAS) and 1-year mortality or HF hospitalization.Results: In 6,549 patients (mean age: 62 ± 13 years], 29% female, 27% HF with preserved ejection fraction), women and those in low SES groups had higher symptom burden but lower signs and similar KCCQ-OS to their respective counterparts. Malay patients had the highest GSSS (3.9) and lowest KCCQ-OS (58.5), and Thai/Filipino/others (2.6) and Chinese patients (2.7) had the lowest GSSS scores and the highest KCCQ-OS (73.1 and 74.6, respectively). Compared to no change, worsening of GSSS (>1-point increase), KCCQ-OS (≥10-point decrease) and VAS (>1-point decrease) were associated with higher risk of HF admission/death (adjusted HR: 2.95 [95% CI: 2.14-4.06], 1.93 [95% CI: 1.26-2.94], and 2.30 [95% CI: 1.51-3.52], respectively). Conversely, the same degrees of improvement in GSSS, KCCQ-OS, and VAS were associated with reduced rates (HR: 0.35 [95% CI: 0.25-0.49], 0.25 [95% CI: 0.16-0.40], and 0.64 [95% CI: 0.40-1.00], respectively). Results were consistent across all sex, ethnicity, and SES groups (interaction P > 0.05).Conclusions: Serial measures of patient-reported symptoms and HRQoL are significant and consistent predictors of outcomes among different groups with HF and provide the potential for a patient-centered and pragmatic approach to risk stratification.

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  • Tay, Wan TingNational Heart Centre Singapore, Singapore (author)
  • Richards, MarkYong Loo Lin School of Medicine, National University of Singapore, Singapore; Christchurch Heart Institute, University of Otago, Dunedin, New Zealand; National University Heart Centre, Singapore (author)
  • Zaccardi, FrancescoNIHR Applied Research Collaboration-East Midlands, University of Leicester, Leicester, United Kingdom; Diabetes Research Centre, Leicester, United Kingdom (author)
  • Tromp, JasperNational Heart Centre Singapore, Singapore; Duke-National University of Singapore Medical School, Singapore, Singapore; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore (author)
  • Teng, Tiew-Hwa KatherineNational Heart Centre Singapore, Singapore; Duke-National University of Singapore Medical School, Singapore, Singapore; School of Allied Health, University of Western Australia, Australia (author)
  • Hung, Chung-LiehDepartment of Cardiology, MacKay Memorial Hospital, Taipei, Taiwan (author)
  • Chandramouli, ChanchalNational Heart Centre Singapore, Singapore; Duke-National University of Singapore Medical School, Singapore, Singapore (author)
  • Wander, Gurpreet SDepartment of Cardiology, Hero Dayanand Medical College Heart Institute, Dayanand Medical College and Hospital, Ludhiana, Punjab, India (author)
  • Ouwerkerk, WouterNational Heart Centre Singapore, Singapore; Department of Dermatology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam Infection and Immunity Institute, Amsterdam, the Netherlands (author)
  • Teramoto, KanakoNational Heart Centre Singapore, Singapore (author)
  • Ali, MohammadDepartment of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom; National Institute for Health Research (NIHR) Biomedical Research Centre, University of Leicester, Leicester, United Kingdom (author)
  • Kadam, UmeshDiabetes Research Centre, Leicester, United Kingdom; Department of Health Sciences, University of Leicester, Leicestershire, United Kingdom (author)
  • Hand, SimonDepartment of Health Sciences, University of Leicester, Leicestershire, United Kingdom (author)
  • Harrison, MaryDepartment of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom (author)
  • Anand, InderCardiovascular Medicine, University of Minnesota, Minneapolis, Minnesota, USA (author)
  • Naik, AjayCare Institute of Medical Sciences, Ahmedabad, India (author)
  • Squire, IainDepartment of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom; National Institute for Health Research (NIHR) Biomedical Research Centre, University of Leicester, Leicester, United Kingdom (author)
  • Khunti, KamleshLeicester Real World Evidence Unit, Leicester, United Kingdom; NIHR Applied Research Collaboration-East Midlands, University of Leicester, Leicester, United Kingdom; Diabetes Research Centre, Leicester, United Kingdom (author)
  • Strömberg, Anna,1967-Linköpings universitet,Avdelningen för omvårdnad och reproduktiv hälsa,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US(Swepub:liu)annst40 (author)
  • Lam, Carolyn S PNational Heart Centre Singapore, Singapore; Duke-National University of Singapore Medical School, Singapore, Singapore; George Institute for Global Health, Sydney, Australia; Department of Cardiology, University of Groningen, Groningen, the Netherlands (author)
  • Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom; National Institute for Health Research (NIHR) Biomedical Research Centre, University of Leicester, Leicester, United Kingdom; Leicester Real World Evidence Unit, Leicester, United Kingdom; NIHR Applied Research Collaboration-East Midlands, University of Leicester, Leicester, United KingdomNational Heart Centre Singapore, Singapore (creator_code:org_t)

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  • In:JACC. Asia: Elsevier3:3, s. 349-3622772-3747

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