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Patient-Reported St...
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Lawson, Claire ADepartment of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom; National Institute for Health Research (NIHR) Biomedical Research Centre, University of Leicester, Leicester, United Kingdom; Leicester Real World Evidence Unit, Leicester, United Kingdom; NIHR Applied Research Collaboration-East Midlands, University of Leicester, Leicester, United Kingdom
(author)
Patient-Reported Status and Heart Failure Outcomes in Asia by Sex, Ethnicity, and Socioeconomic Status
- Article/chapterEnglish2023
Publisher, publication year, extent ...
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Elsevier,2023
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:liu-202818
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-202818URI
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https://doi.org/10.1016/j.jacasi.2023.03.015DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Background: In heart failure (HF), symptoms and health-related quality of life (HRQoL) are known to vary among different HF subgroups, but evidence on the association between changing HRQoL and outcomes has not been evaluated.Objectives: The authors sought to investigate the relationship between changing symptoms, signs, and HRQoL and outcomes by sex, ethnicity, and socioeconomic status (SES).Methods: Using the ASIAN-HF (Asian Sudden Cardiac Death in Heart Failure) Registry, we investigated associations between the 6-month change in a "global" symptoms and signs score (GSSS), Kansas City Cardiomyopathy Questionnaire overall score (KCCQ-OS), and visual analogue scale (VAS) and 1-year mortality or HF hospitalization.Results: In 6,549 patients (mean age: 62 ± 13 years], 29% female, 27% HF with preserved ejection fraction), women and those in low SES groups had higher symptom burden but lower signs and similar KCCQ-OS to their respective counterparts. Malay patients had the highest GSSS (3.9) and lowest KCCQ-OS (58.5), and Thai/Filipino/others (2.6) and Chinese patients (2.7) had the lowest GSSS scores and the highest KCCQ-OS (73.1 and 74.6, respectively). Compared to no change, worsening of GSSS (>1-point increase), KCCQ-OS (≥10-point decrease) and VAS (>1-point decrease) were associated with higher risk of HF admission/death (adjusted HR: 2.95 [95% CI: 2.14-4.06], 1.93 [95% CI: 1.26-2.94], and 2.30 [95% CI: 1.51-3.52], respectively). Conversely, the same degrees of improvement in GSSS, KCCQ-OS, and VAS were associated with reduced rates (HR: 0.35 [95% CI: 0.25-0.49], 0.25 [95% CI: 0.16-0.40], and 0.64 [95% CI: 0.40-1.00], respectively). Results were consistent across all sex, ethnicity, and SES groups (interaction P > 0.05).Conclusions: Serial measures of patient-reported symptoms and HRQoL are significant and consistent predictors of outcomes among different groups with HF and provide the potential for a patient-centered and pragmatic approach to risk stratification.
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Tay, Wan TingNational Heart Centre Singapore, Singapore
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Richards, MarkYong Loo Lin School of Medicine, National University of Singapore, Singapore; Christchurch Heart Institute, University of Otago, Dunedin, New Zealand; National University Heart Centre, Singapore
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Zaccardi, FrancescoNIHR Applied Research Collaboration-East Midlands, University of Leicester, Leicester, United Kingdom; Diabetes Research Centre, Leicester, United Kingdom
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Tromp, JasperNational Heart Centre Singapore, Singapore; Duke-National University of Singapore Medical School, Singapore, Singapore; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore
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Teng, Tiew-Hwa KatherineNational Heart Centre Singapore, Singapore; Duke-National University of Singapore Medical School, Singapore, Singapore; School of Allied Health, University of Western Australia, Australia
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Hung, Chung-LiehDepartment of Cardiology, MacKay Memorial Hospital, Taipei, Taiwan
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Chandramouli, ChanchalNational Heart Centre Singapore, Singapore; Duke-National University of Singapore Medical School, Singapore, Singapore
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Wander, Gurpreet SDepartment of Cardiology, Hero Dayanand Medical College Heart Institute, Dayanand Medical College and Hospital, Ludhiana, Punjab, India
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Ouwerkerk, WouterNational Heart Centre Singapore, Singapore; Department of Dermatology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam Infection and Immunity Institute, Amsterdam, the Netherlands
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Teramoto, KanakoNational Heart Centre Singapore, Singapore
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Ali, MohammadDepartment of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom; National Institute for Health Research (NIHR) Biomedical Research Centre, University of Leicester, Leicester, United Kingdom
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Kadam, UmeshDiabetes Research Centre, Leicester, United Kingdom; Department of Health Sciences, University of Leicester, Leicestershire, United Kingdom
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Hand, SimonDepartment of Health Sciences, University of Leicester, Leicestershire, United Kingdom
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Harrison, MaryDepartment of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom
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Anand, InderCardiovascular Medicine, University of Minnesota, Minneapolis, Minnesota, USA
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Naik, AjayCare Institute of Medical Sciences, Ahmedabad, India
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Squire, IainDepartment of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom; National Institute for Health Research (NIHR) Biomedical Research Centre, University of Leicester, Leicester, United Kingdom
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Khunti, KamleshLeicester Real World Evidence Unit, Leicester, United Kingdom; NIHR Applied Research Collaboration-East Midlands, University of Leicester, Leicester, United Kingdom; Diabetes Research Centre, Leicester, United Kingdom
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Strömberg, Anna,1967-Linköpings universitet,Avdelningen för omvårdnad och reproduktiv hälsa,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US(Swepub:liu)annst40
(author)
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Lam, Carolyn S PNational Heart Centre Singapore, Singapore; Duke-National University of Singapore Medical School, Singapore, Singapore; George Institute for Global Health, Sydney, Australia; Department of Cardiology, University of Groningen, Groningen, the Netherlands
(author)
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Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom; National Institute for Health Research (NIHR) Biomedical Research Centre, University of Leicester, Leicester, United Kingdom; Leicester Real World Evidence Unit, Leicester, United Kingdom; NIHR Applied Research Collaboration-East Midlands, University of Leicester, Leicester, United KingdomNational Heart Centre Singapore, Singapore
(creator_code:org_t)
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In:JACC. Asia: Elsevier3:3, s. 349-3622772-3747
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Lawson, Claire A
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Tay, Wan Ting
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Richards, Mark
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Zaccardi, France ...
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Tromp, Jasper
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Teng, Tiew-Hwa K ...
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Hung, Chung-Lieh
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Chandramouli, Ch ...
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Ouwerkerk, Woute ...
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Teramoto, Kanako
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Ali, Mohammad
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Kadam, Umesh
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Hand, Simon
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Harrison, Mary
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Anand, Inder
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Naik, Ajay
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Squire, Iain
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Khunti, Kamlesh
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Strömberg, Anna, ...
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Lam, Carolyn S P
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JACC. Asia
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