Search: WFRF:(Wedemeyer Heiner) >
Elevation of S2-bou...
Elevation of S2-bound a1-acid glycoprotein is associated with chronic hepatitis C virus infection and hepatocellular carcinoma
-
- Oltmanns, Carlos (author)
- Hannover Med Sch MHH, Germany; Ctr Individualised Infect Med CiiM, Germany; Hannover Med Sch, Germany; TWINCORE, Germany; Hannover Med Sch, Germany
-
- Bremer, Birgit (author)
- Hannover Med Sch MHH, Germany; Hannover Med Sch, Germany
-
- Kusche, Laura (author)
- Hannover Med Sch MHH, Germany
-
show more...
-
- Stal, Per (author)
- Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden
-
- Zenlander, Robin (author)
- Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden; Karolinska Inst, Sweden
-
- Tauwaldt, Jan (author)
- Hannover Med Sch MHH, Germany; Ctr Individualised Infect Med CiiM, Germany; Hannover Med Sch, Germany; TWINCORE, Germany
-
- Rydén, Ingvar (author)
- Linköpings universitet,Avdelningen för klinisk kemi och farmakologi,Medicinska fakulteten
-
- Påhlsson, Peter (author)
- Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten
-
- Cornberg, Markus (author)
- Hannover Med Sch MHH, Germany; Ctr Individualised Infect Med CiiM, Germany; Hannover Med Sch, Germany; TWINCORE, Germany; German Ctr Infect Res DZIF, Germany
-
- Wedemeyer, Heiner (author)
- Hannover Med Sch MHH, Germany; Hannover Med Sch, Germany; German Ctr Infect Res DZIF, Germany
-
show less...
-
(creator_code:org_t)
- 2024
- 2024
- English.
-
In: Journal of Viral Hepatitis. - : WILEY. - 1352-0504 .- 1365-2893.
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- There is an urgent need for new high-quality markers for the early detection of hepatocellular carcinoma (HCC). angstrom strom et al. suggested that S2-bound alpha 1-acid glycoprotein (AGP) might be a promising marker. Consequently, we evaluated the predictive advantage of S2-bound AGP in the early detection of HCC. In a retrospective case-control study of patients chronically infected with hepatitis C virus (HCV) and treated with direct-acting antiviral agents (n = 93), we measured S2-bound AGP using the HepaCheC (R) ELISA kit (Glycobond AB, Linkoping, SE) at the start of treatment, end of treatment and follow-up (maximum: 78 months). Patients were retrospectively propensity score matched (1:2). Thirty-one patients chronically infected with HCV developed HCC after a sustained virological response, while 62 did not. In addition, samples of patients with chronic hepatitis B virus infection, metabolic dysfunction-associated steatotic liver disease and HCC of different etiologies were analysed. S2-bound AGP elevation in HCC patients was confirmed. However, we did not observe a predictive advantage of S2-bound AGP for the early detection of HCC during treatment and follow-up. Interestingly, S2-bound AGP levels correlated with aspartate aminotransferase (rho = .56, p = 9.5x10-15) and liver elastography (rho = .67, p = 2.2x10-16). Of note, S2-bound AGP decreased in patients chronically infected with HCV after treatment-induced HCV clearance. Fucosylated S2-bound AGP levels were elevated in patients with chronic HCV and HCC. The potential role of S2-bound AGP as a novel tumour marker requires further investigation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Keyword
- AST; biomarker; cancer; elastography; HBV; HCC; HCV; MASLD; S2-bound AGP; surveillance
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Oltmanns, Carlos
-
Bremer, Birgit
-
Kusche, Laura
-
Stal, Per
-
Zenlander, Robin
-
Tauwaldt, Jan
-
show more...
-
Rydén, Ingvar
-
Påhlsson, Peter
-
Cornberg, Markus
-
Wedemeyer, Heine ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Gastroenterology ...
- Articles in the publication
-
Journal of Viral ...
- By the university
-
Linköping University