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Elevation of S2-bou...
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Oltmanns, CarlosHannover Med Sch MHH, Germany; Ctr Individualised Infect Med CiiM, Germany; Hannover Med Sch, Germany; TWINCORE, Germany; Hannover Med Sch, Germany
(author)
Elevation of S2-bound a1-acid glycoprotein is associated with chronic hepatitis C virus infection and hepatocellular carcinoma
- Article/chapterEnglish2024
Publisher, publication year, extent ...
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2024
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WILEY,2024
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:liu-202917
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-202917URI
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https://doi.org/10.1111/jvh.13943DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:155474407URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Funding Agencies|Glycobond AB
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There is an urgent need for new high-quality markers for the early detection of hepatocellular carcinoma (HCC). angstrom strom et al. suggested that S2-bound alpha 1-acid glycoprotein (AGP) might be a promising marker. Consequently, we evaluated the predictive advantage of S2-bound AGP in the early detection of HCC. In a retrospective case-control study of patients chronically infected with hepatitis C virus (HCV) and treated with direct-acting antiviral agents (n = 93), we measured S2-bound AGP using the HepaCheC (R) ELISA kit (Glycobond AB, Linkoping, SE) at the start of treatment, end of treatment and follow-up (maximum: 78 months). Patients were retrospectively propensity score matched (1:2). Thirty-one patients chronically infected with HCV developed HCC after a sustained virological response, while 62 did not. In addition, samples of patients with chronic hepatitis B virus infection, metabolic dysfunction-associated steatotic liver disease and HCC of different etiologies were analysed. S2-bound AGP elevation in HCC patients was confirmed. However, we did not observe a predictive advantage of S2-bound AGP for the early detection of HCC during treatment and follow-up. Interestingly, S2-bound AGP levels correlated with aspartate aminotransferase (rho = .56, p = 9.5x10-15) and liver elastography (rho = .67, p = 2.2x10-16). Of note, S2-bound AGP decreased in patients chronically infected with HCV after treatment-induced HCV clearance. Fucosylated S2-bound AGP levels were elevated in patients with chronic HCV and HCC. The potential role of S2-bound AGP as a novel tumour marker requires further investigation.
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Bremer, BirgitHannover Med Sch MHH, Germany; Hannover Med Sch, Germany
(author)
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Kusche, LauraHannover Med Sch MHH, Germany
(author)
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Stal, PerKarolinska Institutet
(author)
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Zenlander, RobinKarolinska Institutet
(author)
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Tauwaldt, JanHannover Med Sch MHH, Germany; Ctr Individualised Infect Med CiiM, Germany; Hannover Med Sch, Germany; TWINCORE, Germany
(author)
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Rydén, IngvarLinköpings universitet,Avdelningen för klinisk kemi och farmakologi,Medicinska fakulteten(Swepub:liu)ingry80
(author)
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Påhlsson, PeterLinköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten(Swepub:liu)petpa61
(author)
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Cornberg, MarkusHannover Med Sch MHH, Germany; Ctr Individualised Infect Med CiiM, Germany; Hannover Med Sch, Germany; TWINCORE, Germany; German Ctr Infect Res DZIF, Germany
(author)
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Wedemeyer, HeinerHannover Med Sch MHH, Germany; Hannover Med Sch, Germany; German Ctr Infect Res DZIF, Germany
(author)
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Hannover Med Sch MHH, Germany; Ctr Individualised Infect Med CiiM, Germany; Hannover Med Sch, Germany; TWINCORE, Germany; Hannover Med Sch, GermanyHannover Med Sch MHH, Germany; Hannover Med Sch, Germany
(creator_code:org_t)
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In:Journal of Viral Hepatitis: WILEY1352-05041365-2893
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Oltmanns, Carlos
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Bremer, Birgit
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Kusche, Laura
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Stal, Per
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Zenlander, Robin
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Tauwaldt, Jan
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Rydén, Ingvar
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Påhlsson, Peter
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Cornberg, Markus
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Wedemeyer, Heine ...
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- MEDICAL AND HEALTH SCIENCES
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Linköping University
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Karolinska Institutet