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Differences in Lymp...
Differences in Lymph Node Metastases Patterns Among Non-pancreatic Periampullary Cancers and Histologic Subtypes: An International Multicenter Retrospective Cohort Study and Systematic Review
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- Uijterwijk, Bas A. (författare)
- Fdn Poliambulanza, Italy; Locat Univ Amsterdam, Netherlands; Canc Ctr Amsterdam, Netherlands
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- Lemmers, Daniel H. (författare)
- Fdn Poliambulanza, Italy; Locat Univ Amsterdam, Netherlands; Canc Ctr Amsterdam, Netherlands
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- Fusai, Giuseppe Kito (författare)
- Royal Free London NHS Fdn Trust, England
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- Zerbi, Alessandro (författare)
- Humanitas Univ, Italy
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- Salvia, Roberto (författare)
- Univ Verona Hosp Trust, Italy
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- Sparrelid, Ernesto (författare)
- Karolinska Inst, Sweden
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- White, Steven (författare)
- Newcastle Tyne Hosp NHS Fdn Trust, England
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- Björnsson, Bergthor (författare)
- Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Kirurgiska kliniken US
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- Mavroeidis, Vasileios K. (författare)
- Royal Marsden Hosp, England; Oxford Univ Hosp NHS Fdn Trust, England
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- Roberts, Keith J. (författare)
- Univ Birmingham, England
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- Mazzola, Michele (författare)
- ASST Grande Osped Metropolitano Niguarda, Italy
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- Cabus, Santiago Sanchez (författare)
- Hosp Santa Creu & Sant Pau, Spain
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- Soonawalla, Zahir (författare)
- Oxford Univ Hosp NHS Fdn Trust, England
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- Korkolis, Dimitris (författare)
- Hellen Anticanc Hosp St Savvas, Greece
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- Serradilla, Mario (författare)
- Miguel Servet Univ Hosp, Spain
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- Pessaux, Patrick (författare)
- Nouvel Hop Civil NHC, France
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- Luyer, Misha (författare)
- Catharina Hosp, Netherlands
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- Mowbray, Nicholas (författare)
- Morriston Hosp, Wales
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- Ielpo, Benedetto (författare)
- Hosp Mar, Spain
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- Mazzotta, Alessandro (författare)
- Inst Mutualiste Montsouris, France
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- Kleeff, Jorg (författare)
- Martin Luther Univ Halle Wittenberg, Germany
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- Boggi, Ugo (författare)
- Pisa Univ Hosp, Italy
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- Munoz, Miguel Angel Suarez (författare)
- Univ Hosp Virgen Victoria, Spain
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- Goh, Brian K. P. (författare)
- Duke Natl Univ Singapore, Singapore
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- Andreotti, Elena (författare)
- Fdn Poliambulanza, Italy
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- Wilmink, Hanneke (författare)
- Univ Amsterdam, Netherlands
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- Ghidini, Michele (författare)
- Fdn IRCCS Ca Granda Osped Maggiore Policlin, Italy
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- Zaniboni, Alberto (författare)
- Fdn Poliambulanza, Italy
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- Verbeke, Caroline (författare)
- Univ Oslo, Norway
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- Adsay, Volkan (författare)
- Koc Univ Hosp, Turkiye; Koc Univ, Turkiye
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- Bianchi, Denise (författare)
- Fdn Poliambulanza, Italy
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- Besselink, Marc G. (författare)
- Locat Univ Amsterdam, Netherlands
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- Abu Hilal, Mohammed (författare)
- Fdn Poliambulanza, Italy
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(creator_code:org_t)
- 2024
- 2024
- Engelska.
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Ingår i: Annals of Surgical Oncology. - : SPRINGER. - 1068-9265 .- 1534-4681.
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Background: Standard lymphadenectomy for pancreatoduodenectomy is defined for pancreatic ductal adenocarcinoma and adopted for patients with non-pancreatic periampullary cancer (NPPC), ampullary adenocarcinoma (AAC), distal cholangiocarcinoma (dCCA), or duodenal adenocarcinoma (DAC). This study aimed to compare the patterns of lymph node metastases among the different NPPCs in a large series and in a systematic review to guide the discussion on surgical lymphadenectomy and pathology assessment. Methods: This retrospective cohort study included patients after pancreatoduodenectomy for NPPC with at least one lymph node metastasis (2010-2021) from 24 centers in nine countries. The primary outcome was identification of lymph node stations affected in case of a lymph node metastasis per NPPC. A separate systematic review included studies on lymph node metastases patterns of AAC, dCCA, and DAC. Results: The study included 2367 patients, of whom 1535 had AAC, 616 had dCCA, and 216 had DAC. More patients with pancreatobiliary type AAC had one or more lymph node metastasis (67.2% vs 44.8%; P < 0.001) compared with intestinal-type, but no differences in metastasis pattern were observed. Stations 13 and 17 were most frequently involved (95%, 94%, and 90%). Whereas dCCA metastasized more frequently to station 12 (13.0% vs 6.4% and 7.0%, P = 0.005), DAC metastasized more frequently to stations 6 (5.0% vs 0% and 2.7%; P < 0.001) and 14 (17.0% vs 8.4% and 11.7%, P = 0.015). Conclusion: This study is the first to comprehensively demonstrate the differences and similarities in lymph node metastases spread among NPPCs, to identify the existing research gaps, and to underscore the importance of standardized lymphadenectomy and pathologic assessment for AAC, dCCA, and DAC.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
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Uijterwijk, Bas ...
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Lemmers, Daniel ...
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Fusai, Giuseppe ...
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Zerbi, Alessandr ...
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Salvia, Roberto
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Sparrelid, Ernes ...
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White, Steven
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Björnsson, Bergt ...
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Mavroeidis, Vasi ...
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Roberts, Keith J ...
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Mazzola, Michele
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Cabus, Santiago ...
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Soonawalla, Zahi ...
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Korkolis, Dimitr ...
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Serradilla, Mari ...
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Pessaux, Patrick
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Luyer, Misha
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Mowbray, Nichola ...
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Ielpo, Benedetto
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Mazzotta, Alessa ...
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Kleeff, Jorg
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Boggi, Ugo
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Munoz, Miguel An ...
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Goh, Brian K. P.
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Andreotti, Elena
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Wilmink, Hanneke
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Ghidini, Michele
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Zaniboni, Albert ...
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Verbeke, Carolin ...
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Adsay, Volkan
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Bianchi, Denise
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Besselink, Marc ...
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Abu Hilal, Moham ...
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