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Demographic and dis...
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Jackmann, NataljaUppsala Univ, Sweden; Univ Childrens Hosp, Sweden
(author)
Demographic and disease-related factors impact bone turnover and vitamin D in children with hemato-oncological diseases
- Article/chapterEnglish2024
Publisher, publication year, extent ...
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OXFORD UNIV PRESS,2024
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:liu-203114
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-203114URI
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https://doi.org/10.1093/jbmrpl/ziae017DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:238523666URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Funding Agencies|Swedish Childhood Cancer Foundation [ST2013-0008, TJ2020-0069, PR2021-0090]; Mary Beves Foundation
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Children with hemato-oncological diseases may have significant skeletal morbidity, not only during and after treatment but also at the time of diagnosis before cancer treatment. This study was designed to evaluate the vitamin D status and circulating bone metabolic markers and their determinants in children at the time of diagnostic evaluation for hemato-oncological disease. This cross-sectional study included 165 children (91 males, median age 6.9 yr range 0.2-17.7 yr). Of them, 76 patients were diagnosed with extracranial or intracranial solid tumors, 83 with leukemia, and 6 with bone marrow failure. Bone metabolism was assessed by measuring serum 25OHD, PTH, bone alkaline phosphatase, intact N-terminal propeptide of type I procollagen, and C-terminal cross-linked telopeptide of type I collagen. Vitamin D deficiency was found in 30.9% of children. Lower 25OHD levels were associated with older age, lack of vitamin D supplementation, season outside summer, and a country of parental origin located between latitudes -45 degrees and 45 degrees. Children diagnosed with leukemia had lower levels of markers of bone formation and bone resorption than those who had solid tumors or bone marrow failure. In conclusion, vitamin D deficiency was observed in one-third of children with newly diagnosed cancer. Bone turnover markers were decreased in children with leukemia, possibly because of the suppression of osteoblasts and osteoclasts by leukemic cells. The identification of patients with suboptimal vitamin D status and compromised bone remodeling at cancer diagnosis may aid in the development of supportive treatment to reduce the adverse effects of cancer and its treatment.
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Gustafsson, JanUppsala Univ, Sweden; Univ Childrens Hosp, Sweden
(author)
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Utriainen, PauliinaUniv Helsinki, Finland; Helsinki Univ Hosp, Finland
(author)
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Magnusson, PerLinköpings universitet,Avdelningen för klinisk kemi och farmakologi,Medicinska fakulteten,Region Östergötland, Klinisk kemi(Swepub:liu)perma28
(author)
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Harila, ArjaUppsala Univ, Sweden; Univ Childrens Hosp, Sweden; Karolinska Inst, Sweden
(author)
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Atanasova, DianaLinköpings universitet,Avdelningen för klinisk kemi och farmakologi,Medicinska fakulteten,Region Östergötland, Klinisk kemi(Swepub:liu)diaat39
(author)
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Rinaldo, CarinaKarolinska Inst, Sweden
(author)
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Frisk, PerUppsala Univ, Sweden; Univ Childrens Hosp, Sweden
(author)
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Makitie, OutiKarolinska Institutet,Univ Helsinki, Finland; Helsinki Univ Hosp, Finland; Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden
(author)
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Uppsala Univ, Sweden; Univ Childrens Hosp, SwedenUniv Helsinki, Finland; Helsinki Univ Hosp, Finland
(creator_code:org_t)
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In:JBMR PLUS: OXFORD UNIV PRESS8:42473-4039
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